A5029307656- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Restless Legs Syndrome Research
- Botulinum Toxin and Related Neurological Disorders
- Visual perception and processing mechanisms
- Sleep and Wakefulness Research
- Genetic Neurodegenerative Diseases
- Genetic and Kidney Cyst Diseases
- Hedgehog Signaling Pathway Studies
- Fetal and Pediatric Neurological Disorders
- Spatial Neglect and Hemispheric Dysfunction
- Long-Term Effects of COVID-19
- Neural dynamics and brain function
- Dysphagia Assessment and Management
- Transcranial Magnetic Stimulation Studies
- Assistive Technology in Communication and Mobility
- Multisensory perception and integration
- EEG and Brain-Computer Interfaces
- Genetic Syndromes and Imprinting
- Children's Physical and Motor Development
- Obsessive-Compulsive Spectrum Disorders
- Nail Diseases and Treatments
- Neurological and metabolic disorders
- Gastrointestinal disorders and treatments
- Cerebral Palsy and Movement Disorders
Ospedale San Carlo
2024
University of Bari Aldo Moro
2023-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2023
IRCCS Istituto Auxologico Italiano
2001-2023
John Wiley & Sons (United States)
2023
Humanitas University
2017-2018
University of Verona
2007-2017
Casa Sollievo della Sofferenza
2013-2016
University of Milan
2016
Casa di Cura Columbus
2011-2015
Abstract Switching from oral medications to continuous infusion of levodopa/carbidopa gel reduces motor complications in advanced Parkinson's disease (PD), but effects on nonmotor symptoms (NMSs) are unknown. In this prospective open‐label observational study, we report the intrajejunal NMS PD based standard assessments utilizing scale (NMSS) along with unified rating (UPDRS 3 and 4 complications) quality life (QoL) using questionnaire (PDQ‐8). Twenty‐two patients (mean age 58.6 years,...
Background Modern management of Parkinson's disease (PD) aims to obtain symptom control, reduce clinical disability, and improve quality life. Music acts as a specific stimulus motor emotional responses by combining movement stimulation different sensory pathways. We explored the efficacy active music therapy (MT) on functions in patients with PD. Methods This prospective, randomized, controlled, single-blinded study lasted 3 months. It consisted weekly sessions MT physical (PT). Thirty-two...
Abstract Drooling is a frequent symptom in Parkinson's disease (PD), occurring almost 75% of all patients. Although it now well known that drooling PD the result swallowing difficulties rather than excessive saliva production, few treatments have been developed to reduce it. Clinical studies suggest botulinum toxin A (BTX) injections into salivary glands are effective decreasing In this double‐blind, placebo‐controlled study, 20 patients with parkinsonism (idiopathic or multiple system...
Abstract Psychotic symptoms are the main and most disabling “nonmotor” complications of Parkinson's disease (PD), pathophysiology which is poorly recognized. Polysomnographic studies have shown a relationship between visual hallucinations rapid eye movement (REM) sleep. The objective this study to clarify psychotic REM sleep behavior disorder (RBD) in PD. In outpatient unit, 289 consecutive subjects with idiopathic PD were administered (in period from January December 2002) multiple‐choice...
Abstract We assessed prospectively clinical and quality of life changes in 9 patients with Parkinson's disease (PD; H&Y ≥ 3) severe motor fluctuations dyskinesia who started continuous daily levodopa duodenal infusion through percutaneous endoscopic gastrostomy. Seven completed the follow‐up period. Duration “off” periods time disabling shortened significantly all ( P < 0.01). Total dose infused did not differ from baseline equivalents. There were significant improvements UPDRS‐II...
Abnormal repetitive behaviors have been reported in Parkinson's disease (PD) during dopamine replacement therapy (DRT) and associated with individual predisposing features, including impulsivity. However, impulsivity compulsive symptoms never explored PD patients before initiation of DRT. We previously a 20% impulse control disorders (ICD) an Italian cohort.103 consecutive newly diagnosed drug-naïve (means: age = 60.5 ± 9.2 years; duration 15.4 15.3 months) were screened for sexual behavior,...
Abstract The objective of this study was to evaluate the relationship between REM sleep behavior disorder (RBD), hallucinations, and cognitive impairment in Parkinson's disease (PD). One hundred ten PD patients, divided into three groups (without RBD or hallucinations; with but no hallucinations), were submitted neuropsychological evaluation. group without hallucinations showed normal tests when compared controls. characterized by a more severe affecting both short‐ long‐term memory, logical...
Abstract There is debate over the cognitive and behavioral effects of deep brain stimulation (DBS) subthalamic nucleus (STN) in advanced Parkinson's disease (PD). To evaluate these effects, we performed a prospective, naturalistic controlled, 3‐year follow‐up study. A total 65 PD patients were enrolled, whom 32 underwent STN‐DBS (PD‐DBS) 33, even though eligible for this treatment, declined surgery chose other therapeutic procedures (PD‐control). Motor neuropsychological functions assessed...
<i>Background:</i> A significant percentage of patients with Parkinson’s disease (PD) continue to experience motor fluctuations and dyskinesias despite the association dopamine agonists levodopa COMT or MAO-B inhibitors. The use apomorphine infusion is limited by compliance while deep brain stimulation feasible only for a small number mostly because age constraints. <i>Objective:</i> To assess prospectively effectiveness duodenal on quality life as well features in...
Recent reports suggest increased frequency of peripheral neuropathy (PN) in Parkinson's disease (PD) patients on levodopa compared with age-matched controls particularly during continuous delivery by intestinal infusion (CLDII). The aim this study is to compare frequency, clinical features, and outcome PN PD undergoing different therapeutic regimens.Three groups consecutive patients, 50 (CLDII), oral (O-LD) other dopaminergic treatment (ODT), were enrolled assess using neurophysiological...
The GREENFIELD observational study assessed the effect of levodopa/carbidopa intestinal gel (LCIG) on motor and non-motor symptoms, related impact patient quality life caregiver burden up to 8 years. Final results a large Italian cohort patients who started LCIG in routine care between 2007 2014 are presented. Comparison baseline (before LCIG) follow-up visits yearly basis (visit 2/3) is reported. Primary endpoint was Unified Parkinson’s Disease Rating Scale (UPDRS-IV) Item 39; secondary...
Abstract Currently, the best treatment option for idiopathic cervical dystonia (ICD) is injection of botulinum toxin (BTX) into affected muscles, whereas rehabilitative approaches have given disappointing results. We evaluated whether association an ad hoc program may improve clinical efficacy BTX in a single‐center, cross‐over, controlled study. Forty patients with ICD were randomly assigned to two different groups: (1) type A (BTX‐A) plus specific physical therapy (BTX‐PT) or (2) BTX‐A...
Effects of dopaminergic medications used to treat Parkinson's disease (PD) may be compared with each other by using conversion factors, calculated as Levodopa equivalent dose (LED). However, current LED proposals on MAO-B inhibitors (iMAO-B) safinamide and rasagiline are still based empirical approaches.To estimate 50 100 mg.In this multicenter, longitudinal, case-control study, we retrospectively reviewed clinical charts 500 consecutive PD patients motor complications treated (i) mg (N =...
Twenty-four-hour ambulatory polysomnography was performed in 20 patients with PD who were having visual hallucinations (12 men and 8 women, mean age 70 +/- 6 years). Visual clearly related to daytime NREM sleep or nocturnal REM 33% of the instances. The data reinforce hypothesis that neural mechanisms implicated generating and, particular, dream imagery play a role occurrence PD.
Introduction Gastrointestinal dysfunction is often described in patients with Parkinson disease (PD), and gastrointestinal symptoms are usually attributed to gastroparesis. The consequent delayed gastric emptying (GE) may be an important pharmacokinetic mechanism underlying some of the response fluctuations that develop after long-term levodopa (L-dopa) therapy. aim this prospective study was assess GE time by a liquid meal scintigraphy, PD patients, correlate them demographic, clinical,...
Oral-facial-digital type VI syndrome (OFDVI) is a rare phenotype of Joubert (JS). Recently, C5orf42 was suggested as the major OFDVI gene, being mutated in 9 11 families (82 %). We sequenced 313 JS probands and identified mutations 28 (8.9 %), most with pure JS. Only 2 out 17 patients (11.7 %) were mutated. A comparison vs. non-mutated showed that preaxial mesoaxial polydactyly, hypothalamic hamartoma other congenital defects may predict mutations, while tongue hamartomas are more common...