A5018615651- Multiple Sclerosis Research Studies
- Reproductive System and Pregnancy
- Polyomavirus and related diseases
- Protease and Inhibitor Mechanisms
- Systemic Lupus Erythematosus Research
- Reproductive tract infections research
- Cytomegalovirus and herpesvirus research
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Systemic Sclerosis and Related Diseases
- Endometriosis Research and Treatment
- RNA regulation and disease
- Blood Coagulation and Thrombosis Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Research on Leishmaniasis Studies
- T-cell and B-cell Immunology
- Autophagy in Disease and Therapy
- Full-Duplex Wireless Communications
- Cervical Cancer and HPV Research
- Peripheral Neuropathies and Disorders
- Cell Adhesion Molecules Research
- Paraoxonase enzyme and polymorphisms
- Animal Virus Infections Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
University of Ferrara
2016-2025
Arcispedale Sant'Anna
2003-2013
Company of Biologists
2007
Abstract Dementia is a neurocognitive disorder characterized by progressive memory loss and impairment in cognitive functional abilities. Autophagy mitophagy are two important cellular processes which the damaged intracellular components degraded lysosomes. To investigate contribution of autophagy degenerative diseases, we investigated serum levels specific autophagic markers (ATG5 protein) mitophagic (Parkin population older patients enzyme-linked immunosorbent assay. Two hundred elderly...
Objective: To validate kappa free light chain (KFLC) and lambda (LFLC) indices as a diagnostic biomarker in multiple sclerosis (MS). Methods: We performed multicenter study including 745 patients from 18 centers (219 controls 526 clinically isolated syndrome (CIS)/MS patients) with known oligoclonal IgG band (OCB) status. KFLC LFLC were measured paired cerebrospinal fluid (CSF) serum samples. Gaussian mixture modeling was used to define cut-off for indexes. Results: The the index 6.6 (95%...
In this study, we employed a sensitive activity assay system to measure cerebrospinal fluid (CSF) and serum levels of active matrix metalloproteinase-9 (MMP-9) in 37 relapsing-remitting (RR), 15 secondary progressive (SP) nine primary (PP) multiple sclerosis (MS) patients, grouped according clinical magnetic resonance imaging (MRI) evidence disease activity. We also studied, as neurological controls, 48 patients with other inflammatory disorders (OIND) non-inflammatory (NIND). To assess...
Significance Multiple sclerosis (MS) is the most common demyelinating disease in young adults. Advances understanding of cellular mechanisms that contribute to MS may help develop new therapies. Here, we elucidated role autophagy (a controlled intracellular pathway regulating degradation components) and mitophagy specific form removes dysfunctional mitochondria) MS. We found human experimental induces a mitochondrial deficit leads activation mitophagy. These phenomena play causal because...
Abstract Background The cerebrospinal fluid (CSF)/serum quotient of albumin (QAlb) is the most used biomarker for evaluation blood–cerebrospinal barrier (B-CSF-B) permeability. For years QAlb was considered only as an age-related parameter but recently it has also been associated to sex. aim present study explore impact sex in determination B-CSF-B dysfunction. Methods analysis retrospectively conducted on subjects consecutively admitted neurological ward. CSF and serum levels were measured...
The gut microbiota is involved in the development of immune system and can modulate risk for immune-mediated disorders such as multiple sclerosis (MS). Dysbiosis has been demonstrated MS patients its restoration by disease-modifying treatments (DMTs) hypothesized. We aimed to study changes composition during first 6 months treatment with dimethyl fumarate (DMF), an oral DMT, identify microorganisms associated DMF side effects. collected analyzed 19 at baseline after 1, 3, treatment. then...
Hypovitaminosis D may play a role in multiple sclerosis (MS), but little is known about intrathecal vitamin D. 25-Hydroxyvitamin was measured cerebrospinal fluid and sera from 36 patients with relapsing-remitting MS, 20 other inflammatory neurological diseases 18 non-inflammatory liquid chromatography-mass spectrometry. There were no significant differences concentrations of 25-hydroxyvitamin D, the fluid:serum ratio significantly lower MS compared (p=0.0012) (p=0.041) patients. The serum...
Chlamydophila pneumoniae is an intracellular pathogen responsible for a number of different acute and chronic infections. The recent deepening knowledge on the biology use increasingly more sensitive specific molecular techniques has allowed demonstration C. in large persons suffering from diseases including cardiovascular (atherosclerosis stroke) central nervous system (CNS) disorders. Despite this, many important issues remain unanswered with regard to role that may play initiating...
The purpose of this study was to investigate intrathecal production and affinity distributions Epstein-Barr virus (EBV)-specific antibodies in multiple sclerosis (MS) controls. Cerebrospinal fluid (CSF) serum concentrations, quantitative synthesis, oligoclonal bands (OCB) patterns anti-Epstein Barr (EBV) were evaluated 100 relapsing-remitting MS (RRMS) patients 200 age- sex-matched controls with other inflammatory neurological disorders (OIND) noninflammatory (NIND). Levels anti-EBNA-1...
It was found that antibodies (Abs) against myelin basic protein (MBP) are the major components of antibody response in multiple sclerosis (MS) patients. We have recently shown IgGs from sera MS patients active hydrolysis MBP. However, literature there no available data concerning possible MBP-hydrolyzing Abs cerebrospinal fluid (CSF) average content their is about 195-fold higher than CSF. Here we compared, for first time, lambda- and kappa-IgGs as well four different subclasses (IgG1-IgG4)...
Background: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Oligoclonal bands (OCBs) in cerebrospinal fluid (CSF) are hallmark MS and reflect intrathecal IgG synthesis inflammation. This study aims to analyze temporal distribution OCBs CSF patients with definitive diagnosis MS. Methods: retrospective included 500 diagnosed Patients were divided into four groups according diagnostic epochs: Group 1 (Pre-2001 or Pre-McDonald), 2 (2001–2010...
An alteration of autophagy and mitophagy, two highly conserved lysosome-dependent degradation pathways involved in the maintenance cellular homeostasis, has been associated with multiple sclerosis (MS).To search level autophagy-related 5 (ATG5) Parkin proteins, as markers mitophagy respectively, lactate a cohort MS patients.Cerebrospinal fluid (CSF) serum samples from 60 patients were analyzed: 30 magnetic resonance imaging (MRI) evidence disease activity, gadolinium (Gd)-based contrast...
We designed a large multicentric study to analyse the presence of MSRV particles in blood and CSF cohort patients controls from different European areas. 149 MS 153 neurological healthy were selected Sardinia, Spain, Northern-Italy Sweden. To avoid biological inter-assay variability was detected within single laboratory through nested real-time PCR assays specific for pol env genes. detection populations ethnicity gave significant differences (p<0.05 compared <0.001 controls). The viral load...