Marcel M. Verbeek
A5008603484- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Parkinson's Disease Mechanisms and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Metabolism and Genetic Disorders
- Neurological disorders and treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cerebrovascular and genetic disorders
- Neurological Disease Mechanisms and Treatments
- S100 Proteins and Annexins
- Neuroinflammation and Neurodegeneration Mechanisms
- Amino Acid Enzymes and Metabolism
- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- Neurological diseases and metabolism
- Diet and metabolism studies
- Amyotrophic Lateral Sclerosis Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Prion Diseases and Protein Misfolding
- Sleep and related disorders
- Nuclear Receptors and Signaling
- Proteoglycans and glycosaminoglycans research
- Neurological Disorders and Treatments
- Heat shock proteins research
- Multiple Sclerosis Research Studies
Radboud University Nijmegen
2016-2025
Radboud University Medical Center
2016-2025
University Medical Center
2012-2024
University Hospital and Clinics
2021-2024
Radboud Institute for Molecular Life Sciences
2021-2024
Max Planck Institute of Psychiatry
2024
Nia Association
2022
ID Genomics (United States)
2022
Erasmus MC
2021
Medisch Centrum Haaglanden
2021
Neurofilament light protein (NfL) is elevated in cerebrospinal fluid (CSF) of a number neurological conditions compared with healthy controls (HC) and candidate biomarker for neuroaxonal damage. The influence age sex largely unknown, levels across disorders have not been systematically to date.
<b>Objective: </b> To determine the optimal timing of somatosensory evoked potential (SSEP) recordings and additional value clinical biochemical variables for prediction poor outcome in patients who remain comatose after cardiopulmonary resuscitation (CPR). <b>Methods: A prospective cohort study was conducted 32 intensive care units including adult still unconscious 24 hours CPR. Clinical, neurophysiologic, were recorded 24, 48, 72 CPR related to death or persisting unconsciousness 1 month....
Biochemical markers have a central position in the diagnosis and management of patients clinical medicine, also research drug development, for brain disorders, such as Alzheimer's disease. The enzyme-linked immunosorbent assay (ELISA) is frequently used measurement low-abundance biomarkers. However, quality ELISA methods varies, which may introduce both systematic random errors. This urges need more rigorous control performance, regardless its use setting, routine, or development. aim method...
<b><i>Objective:</i></b> To study the ability of glial (glial fibrillary acidic protein [GFAP] and S100b) neuronal (neuron specific enolase [NSE]) levels in peripheral blood to predict outcome after severe traumatic brain injury. <b><i>Methods:</i></b> Eighty-five patients with injury (admission Glasgow Coma Score [GCS] ≤ 8) were included. Blood samples taken at time hospital admission analyzed for S100b, GFAP, NSE. Data collected included demographic clinical variables. Outcome was assessed...
Background The cerebrospinal fluid (CSF) biomarkers amyloid β (Aβ)‐42, total‐tau (T‐tau), and phosphorylated‐tau (P‐tau) demonstrate good diagnostic accuracy for Alzheimer's disease (AD). However, there are large variations in biomarker measurements between studies, within laboratories. Association has initiated a global quality control program to estimate monitor variability of measurements, quantify batch‐to‐batch assay variations, identify sources variability. In this article, we present...
Glucose transporter-1 deficiency syndrome is caused by mutations in the SLC2A1 gene majority of patients and results impaired glucose transport into brain. From 2004–2008, 132 requests for mutational analysis were studied automated Sanger sequencing multiplex ligation-dependent probe amplification. Mutations detected 54 (41%) subsequently three clinically affected family members. In these 57 we identified 49 different mutations, including six multiple exon deletions, known 37 novel (13...
Abstract Background The cerebrospinal fluid (CSF) biomarkers amyloid beta 1–42, total tau, and phosphorylated tau are used increasingly for Alzheimer's disease (AD) research patient management. However, there large variations in biomarker measurements among within laboratories. Methods Data from the first nine rounds of Association quality control program was to define extent sources analytical variability. In each round, three CSF samples prepared at Clinical Neurochemistry Laboratory...
Increasing evidence suggests a relationship between poor sleep and the risk of developing Alzheimer disease. A previous study found an effect on β-amyloid (Aβ), which is key protein in disease pathology.To determine 1 night total deprivation cerebrospinal fluid Aβ42 levels healthy middle-aged men.The Alzheimer, Wakefulness, Amyloid Kinetics (AWAKE) at Radboud Center, randomized clinical trial that took place June 1, 2012, October 2012. Participants were cognitively normal men (40-60 years...
This study was designed to establish the reliability of neurologic examination, neuron-specific enolase (NSE), and median nerve somatosensory-evoked potentials (SEPs) predict poor outcome in patients treated with mild hypothermia after cardiopulmonary resuscitation (CPR).This multicenter prospective cohort included adult comatose admitted intensive care unit (ICU) CPR (32-34°C). False-positive rates (FPRs 1 - specificity) their 95% confidence intervals (CIs) were calculated for pupillary...
Objective Sporadic inclusion body myositis (sIBM) is an inflammatory myopathy characterized by both degenerative and autoimmune features. In contrast to other myopathies, myositis‐specific autoantibodies had not been found in sIBM patients until recently. We used human skeletal muscle extracts as a source of antigens detect characterize the corresponding antigen. Methods Autoantibodies were detected immunoblotting. The target antigen was immunoaffinity‐purified from mass spectrometry. A cDNA...
To examine neurofilament (Nf) concentrations according to symptom onset and clinical diagnostic certainty categories of amyotrophic lateral sclerosis (ALS).We measured Nf light chain (NfL) phosphorylated heavy (pNfH) CSF NfL serum levels in patients with ALS first ≤6 months (n = 54) or >6 135) from sampling, other neurologic diseases, differential diagnoses a motor neuron disease (MND mimics), MND variants determine the accuracy early onset. Samples were received multicentric analyzed by...
The small heat shock protein family (sHsp) comprises molecular chaperones able to interact with incorrectly folded proteins. Alzheimer's disease (AD) is characterized by pathological lesions such as senile plaques (SPs), cerebral amyloid angiopathy (CAA) and neurofibrillary tangles (NFTs), predominantly consisting of the proteins amyloid‐β (Aβ) tau respectively. aim this study was investigate association Hsp20, HspB2, αB‐crystallin Hsp27 AD brains. For purpose, a panel well‐characterized...
<b>Objective:</b> To describe the current treatment; clinical, biochemical, and molecular findings; clinical follow-up of patients with aromatic l-amino acid decarboxylase (AADC) deficiency. <b>Method:</b> Clinical biochemical data 78 AADC deficiency were tabulated in a database pediatric neurotransmitter disorders (JAKE). A total 46 have been previously reported; 32 are described for first time. <b>Results:</b> In 96% AADC-deficient patients, symptoms (hypotonia 95%, oculogyric crises 86%,...
Tyrosine hydroxylase deficiency is an autosomal recessive disorder resulting from cerebral catecholamine deficiency. has been reported in fewer than 40 patients worldwide. To recapitulate all available evidence on clinical phenotypes and rational diagnostic therapeutic approaches for this devastating, but treatable, neurometabolic disorder, we studied 36 with tyrosine reviewed the literature. Based presenting neurological features, can be divided two phenotypes: infantile onset, progressive,...