A5009126345- Cardiac Arrest and Resuscitation
- Ultrasound in Clinical Applications
- Hemodynamic Monitoring and Therapy
- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Family and Patient Care in Intensive Care Units
- Sepsis Diagnosis and Treatment
- Healthcare Decision-Making and Restraints
- Palliative Care and End-of-Life Issues
- Chronic Obstructive Pulmonary Disease (COPD) Research
- High Altitude and Hypoxia
- Central Venous Catheters and Hemodialysis
- Emergency and Acute Care Studies
- Radiology practices and education
- Acute Kidney Injury Research
- Dialysis and Renal Disease Management
- Neuroscience of respiration and sleep
- Nosocomial Infections in ICU
- Travel-related health issues
- Healthcare Technology and Patient Monitoring
- Cytomegalovirus and herpesvirus research
- COVID-19 Clinical Research Studies
- EEG and Brain-Computer Interfaces
Rijnstate Hospital
2015-2024
Radboud University Nijmegen
1989-2024
Radboud University Medical Center
2001-2024
Geneeskundige en Gezondheidsdienst
2021-2023
Universidade do Vale do Rio dos Sinos
2018
ASST Fatebenefratelli Sacco
2018
Hospital de Clínicas de Porto Alegre
2018
University of Missouri
2015
University of Twente
2015
Medisch Spectrum Twente
2015
Selective digestive tract decontamination (SDD) and selective oropharyngeal (SOD) are infection-prevention measures used in the treatment of some patients intensive care, but reported effects on patient outcome conflicting.
This study was designed to establish the reliability of neurologic examination, neuron-specific enolase (NSE), and median nerve somatosensory-evoked potentials (SEPs) predict poor outcome in patients treated with mild hypothermia after cardiopulmonary resuscitation (CPR).This multicenter prospective cohort included adult comatose admitted intensive care unit (ICU) CPR (32-34°C). False-positive rates (FPRs 1 - specificity) their 95% confidence intervals (CIs) were calculated for pupillary...
Although inadequate sleep has a proven negative association with health care outcomes, to date, no large-scale studies have examined in general hospital wards.To assess the subjective quantity and quality of identify hospital-related factors associated disturbances hospitalized patients.For this nationwide, single-day, multicenter, cross-sectional, observational study, which took place on February 22, 2017, all hospitals Netherlands were encouraged by word mouth conventional social media...
To provide evidence that early electroencephalography (EEG) allows for reliable prediction of poor or good outcome after cardiac arrest.In a 5-center prospective cohort study, we included consecutive, comatose survivors arrest. Continuous EEG recordings were started as soon possible and continued up to 5 days. Five-minute epochs assessed by 2 reviewers, independently, at 8 predefined time points from 6 hours days arrest, blinded patients' actual condition, treatment, outcome. patterns...
Brain injury affects neurologic function and quality of life in survivors after cardiac arrest.To compare the effects 2 target temperature regimens on long-term cognitive arrest.In this multicenter, international, parallel group, assessor-masked randomized clinical trial performed from November 11, 2010, through January 10, 2013, we enrolled 950 unconscious adults with arrest presumed cause 36 intensive care units Europe Australia. Eleven patients were excluded analysis for a total sample...
Target temperature management is recommended as a neuroprotective strategy after out-of-hospital cardiac arrest. Potential effects of different target temperatures on cognitive impairment commonly described in survivors have not been investigated sufficiently. The primary aim this study was to evaluate whether 33°C compared with 36°C favorable for function; the secondary describe arrest general.Study sites included 652 originally randomized and stratified site control at or within...
IMPORTANCE Selective decontamination of the digestive tract (SDD) and selective oropharyngeal (SOD) are prophylactic antibiotic regimens used in intensive care units (ICUs) associated with improved patient outcome.Controversy exists regarding relative effects both measures on outcome resistance.OBJECTIVE To compare SDD SOD, applied as unit-wide interventions, resistance outcome.DESIGN, SETTING, AND PARTICIPANTS Pragmatic, cluster randomized crossover trial comparing 12 months SOD 16 Dutch...
Because of ongoing controversy, renal and vital outcomes are compared between systemically administered unfractionated heparin regional anticoagulation with citrate-buffered replacement solution in predilution mode, during continuous venovenous hemofiltration (CVVH) critically ill patients acute kidney injury (AKI).In this multi-center randomized controlled trial, admitted to the intensive care unit requiring CVVH meeting inclusion criteria, were randomly assigned citrate or heparin. Primary...
An accurate prediction of the prognosis patients with idiopathic membranous nephropathy (iMN) should allow restriction immunosuppressive treatment to who are at highest risk for ESRD. On basis retrospective studies, it has previously been suggested that urinary excretions beta2-microglobulin (Ubeta2m) and IgG (UIgG) useful predictors renal insufficiency in iMN. The threshold values 0.5 micro/min 250 mg/24 h have validated a new larger patient cohort. From 1995 onward, 57 iMN (38 men, 19...
We recently showed that electroencephalography (EEG) patterns within the first 24 hours robustly contribute to multimodal prediction of poor or good neurological outcome comatose patients after cardiac arrest. Here, we confirm these results and present a cost-minimization analysis. Early prognosis contributes communication between doctors family, may prevent inappropriate treatment.A prospective cohort study including 430 subsequent arrest was conducted at intensive care units two teaching...
Objectives: Visual assessment of the electroencephalogram by experienced clinical neurophysiologists allows reliable outcome prediction approximately half all comatose patients after cardiac arrest. Deep neural networks hold promise to achieve similar or even better performance, being more objective and consistent. Design: Prospective cohort study. Setting: Medical ICU five teaching hospitals in Netherlands. Patients: Eight-hundred ninety-five consecutive Interventions: None. Measurements...
Background In this coronavirus disease 2019 (COVID-19) pandemic, fast and accurate testing is needed to profile patients at the emergency department (ED) efficiently allocate resources. Chest imaging has been considered in COVID-19 workup, but evidence on lung ultrasound (LUS) sparse. We therefore aimed assess compare diagnostic accuracy of LUS computed tomography (CT) suspected patients. Methods This multicentre, prospective, observational study included adult with referred internal...
Previous studies have reported on myocardial injury in patients with coronavirus infectious disease 19 (COVID-19) defined as elevated cardiac biomarkers. Whether biomarkers truly represent dysfunction is not known. The aim of this study was to explore the incidence ventricular and assess its relationship biomarker analyses.
To examine whether a reduced daily glucose load by overnight application of the less-absorbed polymer icodextrin would have favorable effects on lipid profiles continuous ambulatory peritoneal dialysis (CAPD) patients.Randomized crossover study with two subsequent periods 6 weeks.Home PD unit secondary-care hospital.Twenty-one nondiabetic CAPD patients (15 male, female; mean age 50.3+/-11.8 years).Participants were randomly assigned to receive an dwell either standard solution or 7.5%...
Early electroencephalography measures contribute to outcome prediction of comatose patients after cardiac arrest. We present predictive values a new cerebral recovery index, based on combination quantitative measures, extracted every hour, and combined by the use random forest classifier.Prospective observational cohort study.Medical ICU two large teaching hospitals in Netherlands.Two hundred eighty-three consecutive arrest.None.Continuous was recorded during first 3 days. Outcome at 6...
Bengt, Kayser, Ronald Hulsebosch, and Frank Bosch. Low-dose acetylsalicylic acid analog acetazolamide for prevention of acute mountain sickness. High Alt. Med. Biol. 9:15–23, 2008.—Analgesic drugs like acid, paracetamol, ibuprofen are frequently used by subjects suffering from headache sickness (AMS). It is not clear if the effect due to analgesia or AMS. We performed a randomized controlled clinical trial comparing low dose an analog, calcium carbasalate (380 mg /day), placebo in cohort...
Notice of Retraction and Replacement: Oostdijk et al. Effects Decontamination the Oropharynx Intestinal Tract on Antibiotic Resistance in ICUs: A Randomized Clinical Trial. JAMA. 2014;312(14):1429-1437.
<h3>Importance</h3> It remains uncertain whether nebulization of mucolytics with bronchodilators should be applied for clinical indication or preventively in intensive care unit (ICU) patients receiving invasive ventilation. <h3>Objective</h3> To determine if a strategy that uses (on-demand) is noninferior to one preventive (routine) nebulization. <h3>Design, Setting, and Participants</h3> Randomized trial enrolling adult expected need ventilation more than 24 hours at 7 ICUs the...