A5069234530- Neuropeptides and Animal Physiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Stress Responses and Cortisol
- Peptidase Inhibition and Analysis
- Gut microbiota and health
- Parkinson's Disease Mechanisms and Treatments
- Mast cells and histamine
- Receptor Mechanisms and Signaling
- Antimicrobial Peptides and Activities
- Neuroendocrine Tumor Research Advances
- Diabetes and associated disorders
- Bladder and Urothelial Cancer Treatments
- Amino Acid Enzymes and Metabolism
- Extracellular vesicles in disease
- Nerve injury and regeneration
- Neuroendocrine regulation and behavior
- Amyotrophic Lateral Sclerosis Research
- Systemic Lupus Erythematosus Research
- Neurotransmitter Receptor Influence on Behavior
- Atherosclerosis and Cardiovascular Diseases
- Asthma and respiratory diseases
- Whipple's Disease and Interleukins
University of Insubria
2014-2025
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2023-2025
Institute of Immunology
2007-2015
Institute of Virology, Vaccines and Sera “Torlak”
2007-2013
Parkinson's disease (PD) affects an estimated 7 to 10 million people worldwide, and only symptomatic treatments are presently available relieve the consequences of brain dopaminergic neurons loss. Neuronal degeneration in PD is consequence neuroinflammation turn influenced by peripheral adaptive immunity, with CD4+ T lymphocytes playing a key role. cells may however acquire proinflammatory phenotypes, such as helper (Th) 1 Th17, well anti-inflammatory Th2 regulatory (Treg) one, what extent...
Abstract Parkinson’s disease (PD) is characterized by loss of dopaminergic neurons in substantia nigra pars compacta, α-synuclein (α-syn)-rich intraneuronal inclusions (Lewy bodies), and microglial activation. Emerging evidence suggests that CD4+ T lymphocytes contribute to neuroinflammation PD. Since the mainstay PD treatment substitution therapy dopamine an established transmitter connecting nervous immune systems, we examined naive memory patients healthy subjects (HS), with specific...
Bladder cancer (BC) constitutes one of the most diagnosed types worldwide. Advancements in and new methodologies for DNA sequencing, leading to high-throughput microbiota testing, have pinpointed discrepancies urinary microbial fingerprints between healthy individuals patients with BC. Although several studies suggest an involvement dysbiosis pathogenesis, progression, therapeutic response bladder cancer, established direct causal relationship remains be elucidated due lack standardized...
New Findings What is the central question of this study? Glucocorticoids modulate extraglandular catecholamine metabolism and adrenoceptor expression in many cell types. Catecholamines production inflammatory mediators by macrophages. It was hypothesized that adrenal hormones affect tumour necrosis factor‐α rat macrophages altering autocrine/paracrine action catecholamines. main finding its importance? In macrophages, adrenalectomy increased tyrosine hydroxylase expression, decreased...
Summary The neurotransmitter dopamine (DA) has prominent effects in the immune system and between cells, CD4 + regulatory T (Treg) lymphocytes, a specialized T‐cell subset crucial for control of homeostasis, are especially sensitive to DA. Dopaminergic receptors (DR) grouped into two families according their pharmacological profile main second messenger coupling: D 1 ‐like (D 5 ), which activate adenylate cyclase, 2 , 3 4 inhibit cyclase exist several variants that have been associated...
The inducible T cell co-stimulator ligand (ICOSL), expressed by antigen presenting cells, binds to the (ICOS) on activated cells. Improper function of ICOS/ICOSL pathway has been implicated in several autoimmune diseases, including multiple sclerosis (MS). Previous studies showed that ICOS-knockout (KO) mice exhibit severe experimental encephalomyelitis (EAE), animal model MS, but data ICOSL deficiency are not available. In our study, we explored impact both ICOS and deficiencies MOG
<i>Background:</i> Given that stressful experiences can change the reaction to a subsequent exposure stress, we tested in vitro effects of stress mediator corticosterone and opioid peptide β-endorphin on function macrophages isolated from control rats exposed electric tail shock (ES) or stress-witnessing procedure (SW) 24 h earlier. <i>Methods:</i> Peritoneal stressed Dark Agouti (DA) strain were treated with for adherence, phagocytosis hydrogen peroxide release....