A5087087615- Hematopoietic Stem Cell Transplantation
- Neonatal Health and Biochemistry
- Neonatal Respiratory Health Research
- Mesenchymal stem cell research
- Blood groups and transfusion
- Neonatal and fetal brain pathology
- Retinopathy of Prematurity Studies
- Erythrocyte Function and Pathophysiology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Platelet Disorders and Treatments
- Blood disorders and treatments
- Neutropenia and Cancer Infections
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Blood transfusion and management
- Angiogenesis and VEGF in Cancer
- Long-Term Effects of COVID-19
- Ocular Surface and Contact Lens
- Cardiac, Anesthesia and Surgical Outcomes
- Neuroendocrine Tumor Research Advances
- Multiple Myeloma Research and Treatments
- Liver physiology and pathology
- Zebrafish Biomedical Research Applications
- Iron Metabolism and Disorders
Agostino Gemelli University Polyclinic
2017-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2024
Buffalo Medical Group
2018-2023
Philadelphia University
2018-2023
University of Minnesota Rochester
2018-2023
Baylor College of Medicine
2018-2023
Università Cattolica del Sacro Cuore
2013-2021
Catholic University of America
2015
Pfizer (United States)
2004
Christchurch Hospital
2004
Purpose This phase III, randomized, open-label, multicenter study compared the overall survival associated with irinotecan plus gemcitabine (IRINOGEM) versus monotherapy (GEM) in patients chemotherapy-naive, locally advanced or metastatic pancreatic cancer. Patients and Methods IRINOGEM received starting doses of 1,000 mg/m 2 100 given weekly for weeks every 3-week cycle. GEM 7 8 (induction) then 3 4 weeks. The primary end point trial was survival. Secondary points included tumor response,...
Article abstract-Cabergoline is a potent D<sub>2</sub> receptor agonist with half-life of 65 hours that may provide continuous dopaminergic stimulation administered once daily. In this study, we randomized de novo Parkinson9s disease (PD) patients to treatment increasing doses cabergoline (0.25 4 mg/d) or levodopa (100 600 up the optimal maximum tolerated dose. Decreases >30% in motor disability (Unified Disease Rating Scale Factor III) versus baseline were considered indicative clinical...
Repeated red blood cell (RBC) transfusions in preterm neonates are associated with poor outcome and increased risk for prematurity-associated diseases. RBC cause the progressive replacement of fetal haemoglobin (HbF) by adult (HbA). We monitored HbF levels 25 until 36 weeks post-menstrual age (PMA); patients received units from allogeneic cord (cord-RBCs) or donors (adult-RBCs), depending on whether cord-RBCs were available. Primary was level at PMA 32 weeks. Twenty-three survived this age:...
Abstract Background Extremely low gestational age neonates (ELGANs, i.e., born before 28 weeks of gestation) are at high risk developing retinopathy prematurity (ROP), with potential long-life visual impairment. Due to concomitant anemia, ELGANs need repeated red blood cell (RBC) transfusions. These produce a progressive replacement fetal hemoglobin (HbF) by adult (HbA). Furthermore, close association exists between levels HbF and severe ROP, suggesting that perturbation the HbF-mediated...
Repeated red blood cell (RBC) transfusions are thought to increase the risk for retinopathy of prematurity (ROP), likely due a critical fetal hemoglobin (HbF) reduction. In this study, we investigated if postmenstrual age (PMA) neonates at transfusion influences ROP. We estimated cumulative transfusion-free survival (TFS) in series 100 preterm receiving one or more RBC units. TFS was calculated by censoring patients first and expressing time between birth as either PMA postnatal day. Then,...
To evaluate the safety of subretinal injection cord blood platelet-rich plasma (CB-PRP) and its possible effect in eyes affected by geographic atrophy (GA) associated with dry age-related macular degeneration (d-AMD).
It is still under debate whether granulocyte transfusions (GTs) substantially increase survival in patients with febrile neutropenia. We retrospectively examined data relative to 96 hematological malignancies receiving 491 GTs during 114 infectious episodes (IE). Patients were grouped according the median doses of granulocytes transfused episode (low-dose group: <1.5-x108 cells/Kg; standard-dose 1.5–3.0x108 cells/Kg and high-dose >3.0x108 cells/Kg). The impact clinical, microbiological...
Background: Hypoxia-inducible factor (HIF-1) is a transcription produced in hypoxia condition, it closely associated with tumor angiogenesis and metastasis. Aim: To investigate the expression of HIF-1α relation presence or absence bone Methods A retrospective analysis was carried out on samples deriving from bronchial biopsy CT-guided trans-thoracic needle biopsy. Detection HIF-1 performed tissue sample by monoclonal murine antibody, comparing patients without metastases (BM+). Findings: In...
Platelet-rich plasma (PRP) is an inexpensive and safe substitute of recombinant growth factors in Vitro vivo. Due to its putative effect on tissue repair, the use autologous PRP has become largely popular. Recently, a jellified derivative obtained from umbilical cord blood (CB) been utilized vivo treat mucosal cutaneous lesions. Nevertheless, whether derived CB adult display different potency promoting cell rarely investigated. In this study, we compared cytokine profile mesenchymal...
The impact of ABO incompatibility (ABO-I) on hematopoietic stem cell transplant outcomes is still debated.We retrospectively investigated 432 consecutive transplants performed at our center (2012-2020). All patients but 6 were affected by hematologic malignancies. effect different match combinations engraftment rate, transfusion support, acute and chronic graft-versus-host disease incidences, nonrelapse mortality (NRM), disease-free survival, overall survival was assessed in univariate...
The detection of irregular antibody is a critical issue in the management red blood cell transfusion according to Type & Screen (T&S) practice. In order implement T&S procedure at our bank, we compared three different automated analyzers based on column agglutination technique (CAT) or solid phase adherence assay (SPACA) methods.Pre-transfusion screening was performed 986 patients candidate elective surgery low risk for transfusion. We tested following kits: three-cell panel micro-CAT system...
Ocular chronic GVHD is efficaciously treated with autologous platelet‐derived eye drops. We investigated the cytokine content of drops produced using a non‐gelified lysate obtained from platelet‐rich plasma in six patients ocular . In both responding ( n = 4) and resistant 2) patients, were significantly enriched various growth factors, amounts proportional platelet counts. contrast, chemokine ligand interleukin levels similar to those plasma. The non‐responding showed highest (C‐X‐C motif)...
For neonates and preterm infants, in whom a transfusion dose is low, the use of red blood cells (RBC) from cord appears to be feasible. Standardisation fractionation identification assessment quality control parameters for such RBC are still lacking.We describe process used obtain purposes, including controls evaluate performance effects storage. The RBC, which SAG-M was added, were sampled on day fractionation, 7 14 days (end storage) later order measure complete count, biochemical residual...
Defibrotide (DFB) effects on different endothelial cell pathways have been investigated focusing a limited number of genes or molecules. This study explored the modulation gene expression profile steady-state lipopolysaccharide (LPS)-activated cells, following DFB exposure. Starting from differentially regulated datasets, we utilized Ingenuity Pathway Analysis (IPA) to infer novel information about activity this drug. We found that elicited by LPS deeply differ depending cells were exposed...
Patients affected by transfusion-dependent β-thalassemia are prone to developing several clinical complications, mostly related the iron overload. We report case of a patient (TDT) acute promyelocytic leukemia (APL). In our case, therapeutic management was significantly complicated not only myocardial dysfunction, but also occurrence differentiation syndrome following all-trans retinoic acid (ATRA) administration. carried out careful revision current literature on hematological malignancies...