A5014613164- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neural Engineering
- Botulinum Toxin and Related Neurological Disorders
- Obsessive-Compulsive Spectrum Disorders
- Mitochondrial Function and Pathology
- Advanced MRI Techniques and Applications
- Glycogen Storage Diseases and Myoclonus
- Advanced Neuroimaging Techniques and Applications
- Phytochemistry and Bioactive Compounds
- Steroid Chemistry and Biochemistry
- Restless Legs Syndrome Research
- Peripheral Neuropathies and Disorders
- Neural dynamics and brain function
- Retinal and Optic Conditions
- Insect and Pesticide Research
- Autism Spectrum Disorder Research
- Cellular transport and secretion
- Physical Activity and Health
- Health, Medicine and Society
- Acute Myeloid Leukemia Research
- Hereditary Neurological Disorders
- Lysosomal Storage Disorders Research
University Hospital of Bern
2013-2022
University of Bern
2013-2022
Inserm
2009-2022
Pitié-Salpêtrière Hospital
2004-2022
Sorbonne Université
2009-2022
Institut du Cerveau
2012-2022
Assistance Publique – Hôpitaux de Paris
2012-2022
Centre for Movement Disorders
2019
Neurology, Inc
2017-2018
University of Basel
1964-2015
Subthalamic nucleus deep brain stimulation improves motor symptoms and quality of life in advanced Parkinson's disease. As after other life-altering surgeries, suicides have been reported following for movement disorders. We sought to determine the suicide rate subthalamic disease by conducting an international multicentre retrospective survey disorder surgical centres. further factors associated with attempts through a nested case-control study. In rate, 55/75 centres participated. The...
To prospectively evaluate the impact of subthalamic nucleus (STN) stimulation on social adjustment in patients with Parkinson disease (PD).Before and 18 to 24 months after bilateral STN stimulation, authors assessed 29 PD for motor disability, cognition (Mattis dementia rating scale, frontal score), psychiatric morbidity (Mini-5.0.0, MADRS, BAS), quality life (PDQ-39), (Social Adjustment Scale), psychological status using unstructured in-depth interviews.Despite marked improvement...
Two parkinsonian patients who experienced transient hypomanic states when the subthalamic nucleus (STN) was stimulated during postoperative adjustment of electrical parameters for antiparkinsonian therapy agreed to have mood disorder reproduced, in conjunction with motor, cognitive, and behavioral evaluations concomitant functional neuroimaging. During experiment, STN stimulation again induced a state activation cortical thalamic regions known process limbic associative information. This...
The short term benefits of bilateral stimulation the subthalamic nucleus (STN) in patients with advanced levodopa responsive Parkinson's disease (PD) are well documented, but long still uncertain. This study provides a 5 year follow up PD treated STN. Thirty seven consecutive STN were assessed prospectively 6, 24, and 60 months after neurosurgery. Parkinsonian motor disability was evaluated without treatment, stimulation. Neuropsychological mood assessments included Mattis Dementia Rating...
Deep brain stimulation of different targets has been shown to drastically improve symptoms a variety neurological conditions. However, the occurrence disabling side effects may limit ability deliver adequate amounts current necessary reach maximal benefit. Computed models have suggested that reduction in electrode size and provide directional could increase efficacy such therapies. This never demonstrated humans. In present study, we assess effect compared omnidirectional stimulation. Three...
Stimulation of the subthalamic nucleus is an effective treatment for advanced Parkinson disease (PD) and currently performed after a mean duration 14 years, when severe motor complications have resulted in marked loss quality life. We examined whether surgery at early stage would maintain life as well improve function.Twenty patients with PD short (time elapsed since first symptom +/- SD: 6.8 1.0 years) mild to moderate signs (Unified Parkinson's Disease Rating Scale III "off" medication: 29...
To evaluate the effects of dopamine D2-D3 agonist ropinirole in patients who developed apathy after complete withdrawal from dopaminergic medication following successful subthalamic nucleus (STN) stimulation for advanced Parkinson disease (PD). We assessed (Apathy Scale, Apathy Inventory), mood (Montgomery-Asberg Depression Rating Scale), cognitive functions (Mattis Dementia rating scale, frontal score, executive tests) and motor state (UPDRS-III) 8 PD treated with STN without treatment...
Bilateral basal ganglia lesions have been reported to induce a particular form of apathy, termed auto-activation deficit (AAD), principally defined as loss self-driven behaviour that is reversible with external stimulation. We hypothesized AAD reflects dysfunction incentive motivation, process translates an expected reward (or goal) into behavioural activation. To investigate this hypothesis, we designed paradigm contrasting instructed (externally driven) task, in which subjects produce...
To further determine the causes of variable outcome from deep brain stimulation subthalamic nucleus (DBS-STN) in patients with Parkinson disease (PD).Data were obtained our cohort 309 PD who underwent DBS-STN between 1996 and 2009. We examined relationship 1-year motor, cognitive, psychiatric outcomes (1) preoperative clinical features, (2) MRI measures, (3) surgical procedure, (4) locations therapeutic contacts.Pre- postoperative results 262 PD. The best motor was when stimulating contacts...
Haematopoietic stem cell transplantation has been proposed as treatment for mitochondrial neurogastrointestinal encephalomyopathy, a rare fatal autosomal recessive disease due to TYMP mutations that result in thymidine phosphorylase deficiency. We conducted retrospective analysis of all known patients suffering from encephalomyopathy who underwent allogeneic haematopoietic between 2005 and 2011. Twenty-four patients, 11 males 13 females, median age 25 years (range 10–41 years) treated with...
Abstract The “Ardouin Scale of Behavior in Parkinson's Disease” is a new instrument specifically designed for assessing mood and behavior with view to quantifying changes related disease, dopaminergic medication, non‐motor fluctuations. This study was aimed at analyzing the psychometric attributes this scale patients disease without dementia. In addition scale, following measures were applied: Unified Disease Rating Scale, Montgomery Asberg Depression Lille Apathy Bech Rafaelsen Mania...
Abstract Sensing-based deep brain stimulation should optimally consider both the motor and neuropsychiatric domain to maximize quality of life Parkinson’s disease (PD) patients. Here we characterize neurophysiological properties subthalamic nucleus (STN) in 69 PD patients using a newly established gradient metric contextualize it with symptoms apathy. We could evidence STN power that holds most spectral information between 5 30 Hz spanning along dorsal-ventral axis. It shows elevated...
Background Repetitive behaviours (RB) in patients with Gilles de la Tourette syndrome (GTS) are frequent. However, a controversy persists whether they manifestations of obssessive-compulsive disorder (OCD) or correspond to complex tics. Methods 166 consecutive GTS aged 15–68 years were recruited and submitted extensive neurological, psychiatric psychological evaluations. RB evaluated by the YBOCS symptom checklist Mini International Neuropsychiatric Interview (M.I.N.I), classified on basis...
The localization of any given target in the brain has become a challenging issue because increased use deep stimulation to treat Parkinson disease, dystonia, and nonmotor diseases (for example, Tourette syndrome, obsessive compulsive disorders, depression). aim this study was develop an automated method adapting atlas human basal ganglia brains individual patients.Magnetic resonance images specimen were obtained before extraction from skull histological processing. Adaptation patient anatomy...
Abstract Background Effects of DBS on freezing gait and other axial signs in PD patients are unclear. Objective Secondary analysis to assess whether affects these symptoms within a large randomized controlled trial comparing the STN combined with best medical treatment alone early motor complications (EARLYSTIM‐trial). Methods One hundred twenty‐four were stimulation group 127 group. Presence was assessed worst condition based item‐14 UPDRS‐II at baseline follow‐up. The posture, instability,...
Abstract Gilles de la Tourette syndrome is a neurodevelopmental disorder characterized by the presence of motor and vocal tics. We hypothesized that patients with this would present an aberrant pattern cortical formation, which could potentially reflect global alterations brain development. Using 3 Tesla structural neuroimaging, we compared sulcal depth, opening, length thickness gray matter in 52 adult matched controls. Cortical sulci were automatically reconstructed identified over whole...
In the present study, we examined potential symptomatic and/or disease-modifying effects of monthly bee venom injections compared to placebo in moderatly affected Parkinson disease patients. We conducted a prospective, randomized double-blind study 40 patients at Hoehn & Yahr stages 1.5 3 who were either assigned or equivalent volumes saline (treatment/placebo group: n = 20/20). The primary objective this was assess effect s.c. (100 μg) 11 months after initiation therapy on United...