A5023768737- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neural Engineering
- Genetic Neurodegenerative Diseases
- Advanced MRI Techniques and Applications
- Botulinum Toxin and Related Neurological Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- EEG and Brain-Computer Interfaces
- Advanced Neuroimaging Techniques and Applications
- Acute Ischemic Stroke Management
- Parkinson's Disease and Spinal Disorders
- Cerebrospinal fluid and hydrocephalus
- Glioma Diagnosis and Treatment
- Sympathectomy and Hyperhidrosis Treatments
- Pain Management and Treatment
- Glycogen Storage Diseases and Myoclonus
- Trigeminal Neuralgia and Treatments
- Fetal and Pediatric Neurological Disorders
- Epilepsy research and treatment
- Migraine and Headache Studies
- Neurosurgical Procedures and Complications
- Memory and Neural Mechanisms
- Medical Imaging and Pathology Studies
- Lower Extremity Biomechanics and Pathologies
University Hospital of Bern
2015-2025
University of Bern
2015-2025
University Medical Center of the Johannes Gutenberg University Mainz
2024
Johannes Gutenberg University Mainz
2024
University Medical Center
2024
University Hospital and Clinics
2024
University of Oxford
2019-2024
University of Minnesota
2020
Resonance Research (United States)
2020
John Radcliffe Hospital
2019
OBJECTIVE The effectiveness and optimal stimulation site of deep brain (DBS) for central poststroke pain (CPSP) remain elusive. objective this retrospective international multicenter study was to assess clinical as well neuroimaging-based predictors long-term outcomes after DBS CPSP. METHODS authors analyzed patient-based neuroimaging data previously published unpublished cohorts from 6 centers. leads were reconstructed normalized. A map constructed on the basis individual settings...
Although recently introduced directional DBS leads provide control of the stimulation field, programing is time-consuming.Here, we validate local field potentials recorded from contacts as a predictor most efficient for in patients with PD.Intraoperative were STN 12 and beta activity compared results clinical contact review performed after 4 to 7 months.Normalized was positively correlated contact's efficacy. The two highest included up 92% that widest therapeutic window 74% cases.Local...
Abstract Although deep brain stimulation (DBS) of the globus pallidus internus (GPi) and subthalamic nucleus (STN) has become an established treatment for Parkinson’s disease (PD), a recent meta-analysis outcomes is lacking. To address this gap, we performed bilateral STN- GPi-DBS studies published from 1990-08/2019. Studies with ≥10 subjects reporting Unified Disease Rating Scale (UPDRS) III motor scores at baseline 6–12 months follow-up were included. Several outcome variables analyzed...
Deep brain stimulation (DBS) programming of multicontact DBS leads relies on a very time-consuming manual screening procedure, and strategies to speed up this process are needed. Beta activity in subthalamic nucleus (STN) local field potentials (LFP) has been suggested as promising marker index optimal contacts patients with Parkinson disease.In study, we investigate the advantage algorithmic selection combination multiple resting movement state features from STN LFPs imaging markers predict...
Abstract Sensing-based deep brain stimulation should optimally consider both the motor and neuropsychiatric domain to maximize quality of life Parkinson’s disease (PD) patients. Here we characterize neurophysiological properties subthalamic nucleus (STN) in 69 PD patients using a newly established gradient metric contextualize it with symptoms apathy. We could evidence STN power that holds most spectral information between 5 30 Hz spanning along dorsal-ventral axis. It shows elevated...
OBJECTIVE The dentatorubrothalamic tract (DRTT) has been suggested as the anatomical substrate for deep brain stimulation (DBS)–induced tremor alleviation. So far, little is known about how accurately and reliably tracking results correspond to DRTT. objective of this study was systematically investigate validate different tractography approaches surgical planning. METHODS authors retrospectively analyzed 4 methodological diffusion tensor imaging (DTI)–based fiber using regions interest in 6...
The objective of this study was to obtain individual clinical and neuroimaging data patients undergoing deep brain stimulation (DBS) for essential tremor (ET) from 5 different European centers identify predictors outcome an optimal site.We analyzed retrospectively baseline covariates, pre- postoperative scores (for 12 months) as well imaging 119 electrode positions volumes. Individual were used calculate a probabilistic map in normalized space using voxel-wise statistical analysis. Finally,...
Whilst exaggerated bursts of beta frequency band oscillatory synchronization in the subthalamic nucleus have been associated with motor impairment Parkinson's disease, a plausible mechanism linking two phenomena has lacking. Here we test hypothesis that increased denoted by bursting might compromise information coding capacity basal ganglia networks. To this end recorded local field potential activity 18 patients disease as they executed cued upper and lower limb movements. We used accuracy...
Abstract Background The landscape of neurophysiological symptoms and behavioral biomarkers in basal ganglia signals for movement disorders is expanding. clinical translation sensing‐based deep brain stimulation (DBS) also requires a thorough understanding the anatomical organization spectral within subthalamic nucleus (STN). Objectives aims were to systematically investigate topography, including wide range sub‐bands STN local field potentials (LFP) Parkinson's disease (PD) patients,...
Subthalamic nucleus deep brain stimulation (STN-DBS) is a well-established treatment for motor complications in Parkinson's disease (PD). However, its effects on neuropsychiatric symptoms remain disputed. The aim of this study was to evaluate the STN-DBS PD.
Background: Subthalamic nucleus (STN) stimulation has been recognized to control resting tremor in Parkinson disease. Similarly, thalamic (ventral intermediate nucleus; VIM) shown disease, essential, and intention tremors. Recently, of the posterior subthalamic area (PSA) associated with excellent control. Thus, optimal site may be located surrounding white matter. Aims: The objective this work was investigate by determining contact location correlated best STN/VIM patients. Methods: mean...
Accurate interindividual comparability of deep brain stimulation (DBS) lead locations in relation to the surrounding anatomical structures is eminent importance define and understand effective areas. The objective current work compare accuracy DBS localisation relative STN native space with four recently developed three-dimensional subcortical atlases MNI template space. Accuracy reviewed by volumetric analysis as well intraoperative electrophysiological data. Postoperative localisations 10...
Functional processes in the brain are segregated both spatial and spectral domain. Motivated by findings reported at cortical level healthy participants we test hypothesis basal ganglia of Parkinson's disease patients that lower frequency beta band activity relates to motor circuits associated with upper limb higher frequencies movements. We recorded local field potentials (LFPs) from subthalamic nucleus using segmented "directional" DBS leads, during which performed repetitive...
Directional deep brain stimulation (DBS) allows for steering of the field, but extensive and time-consuming testing all segmented contacts is necessary to identify possible benefit steering. It therefore important determine under which circumstances directional current advantageous.Fifty two Parkinson's disease patients implanted in STN with a DBS system underwent standardized monopolar programming session 5 9 months after implantation. Individual were tested potential advantage stimulation....
Stereotactic biopsies for brainstem lesions are frequently performed to yield an accurate diagnosis and help guide subsequent management. In this study, we summarize our experience with different stereotactic approaches of locations discuss possible implications safety diagnostic yield.We retrospectively analyzed 23 adult patients who underwent a biopsy between October 2011 December 2019. Depending on the location supra- or infratentorial, trajectories were planned. We assessed postoperative...
Abstract Background Novel commercial brain‐sense neurostimulators enable us to contextualize brain activity with symptom and medication states in real‐life ambulatory settings Parkinson's disease (PD). Although various candidate biomarkers have been proposed for adaptive deep stimulation (DBS), a comprehensive comparison of their profiles is lacking. Objectives To systematically compare the neurophysiological dynamics clinical properties three biomarkers—low‐frequency, beta (β), finely tuned...
Deep brain stimulation (DBS) of the posterior subthalamic area (PSA) is an alternative to thalamic DBS for treatment essential tremor (ET). The dentato-rubro-thalamic tract (DRTT) has recently been proposed as anatomical substrate underlying effective stimulation. For clinical purposes, depiction DRTT mainly depends on diffusion tensor imaging (DTI)-based tractography, which some drawbacks. objective this study was present accurate targeting strategy PSA based landmarks visible MRI and...
Abstract Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for advanced Parkinson's disease. Stimulation hyperdirect pathway (HDP) may mediate beneficial effects, whereas corticospinal tract (CST) mediates capsular side effects. The study's objective was to suggest parameters based on activation HDP and CST. This retrospective study included 20 disease patients with bilateral STN DBS. Patient‐specific whole‐brain probabilistic tractography performed...
Ictal SPECT is an informative seizure imaging technique to tailor epilepsy surgery. However, capturing the onset of unpredictable seizures a medical and logistic challenge. Here, we sought image planned triggered by direct stimulation epileptic networks via stereotactic electroencephalography (sEEG) electrodes. <b>Methods:</b> In this case series 3 adult participants with left temporal epilepsy, identified stimulated sEEG contacts able trigger patient-typical seizures. We administered...