A5068135962- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Neuroscience and Neural Engineering
- Muscle activation and electromyography studies
- Restless Legs Syndrome Research
- Voice and Speech Disorders
- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease and Spinal Disorders
- Brain Tumor Detection and Classification
- Acute Ischemic Stroke Management
- Electroconvulsive Therapy Studies
- Autism Spectrum Disorder Research
- Balance, Gait, and Falls Prevention
- Photoacoustic and Ultrasonic Imaging
- Neurological Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Artificial Intelligence in Healthcare
- Transcranial Magnetic Stimulation Studies
- Neurology and Historical Studies
- Pain Management and Treatment
- Gait Recognition and Analysis
- Blood Coagulation and Thrombosis Mechanisms
- Autoimmune Neurological Disorders and Treatments
- Trace Elements in Health
Università Campus Bio-Medico
2016-2025
Campus Bio Medico University Hospital
2022-2025
Innova (Italy)
2021-2025
John Radcliffe Hospital
2017-2019
University of Oxford
2016-2019
MRC Brain Network Dynamics Unit
2016-2017
Medical Research Council
2016-2017
Istituti di Ricovero e Cura a Carattere Scientifico
2017
University Health Network
2017
University of Salerno
2017
Although recently introduced directional DBS leads provide control of the stimulation field, programing is time-consuming.Here, we validate local field potentials recorded from contacts as a predictor most efficient for in patients with PD.Intraoperative were STN 12 and beta activity compared results clinical contact review performed after 4 to 7 months.Normalized was positively correlated contact's efficacy. The two highest included up 92% that widest therapeutic window 74% cases.Local...
See Vidailhet et al. (doi:10.1093/brain/awx140) for a scientific commentary on this article. Misdiagnosis among tremor syndromes is common, and can impact both clinical care research. To date no validated neurophysiological technique available that has proven to have good classification performance, the diagnostic gold standard evaluation made by movement disorders expert. We present robust new measure, stability index, which discriminate Parkinson’s disease essential with high accuracy. The...
In the last decades, several studies showed that wearable sensors, used for assessing Parkinson's disease (PD) motor symptoms and recording their fluctuations, could provide a quantitative reliable tool patient's performance monitoring.The aim of this study is to make step forward capability quantitatively describing PD symptoms. The specific aims are: identify most sensible place where locate sensors monitor bradykinesia rigidity, objective indexes able discriminate OFF/ON status, patients...
The present study explores brain connectivity in Parkinson's disease (PD) and age matched healthy controls (HC), using quantitative EEG analysis, at rest during a motor tasks. We also evaluated the diagnostic performance of phase locking value (PLV), measure functional connectivity, differentiating PD patients from HCs.High-density, 64-channels, data 26 13 HC were analyzed. signals recorded task. Phase as was for each group resting state task following frequency bands: (i) delta: 2-4 Hz;...
Interleaving stimulation (ILS) in deep brain (DBS) provides individualized of 2 contacts delivered alternating order. Currently, limited information on the utility ILS exists. The aims this study were to determine practical applications and outcomes DBS Parkinson's disease (PD), tremor, dystonia.We performed a single-center, unblinded, retrospective chart review all patients with attempted at our referral center assessing for rationale outcomes.Fifty (PD, n = 27; 7; dystonia, 16 patients)...
Abstract Introduction The recently released classification has revised the nosology of tremor, defining essential tremor (ET) as a syndrome and fueling an enlightened debate about some newly conceptualized entities such ET-plus. As result, precise information demographics, clinical features, natural history these conditions are lacking. Methods ITAlian Network (TITAN) is multicenter data collection platform, aim which to prospectively assess, according standardized protocol, phenomenology...
Parkinson's disease (PD) is a neurodegenerative brain disorder that slowly brings on the dopaminergic neurons death. The depletion of signal causes onset motor symptoms such as tremor, bradykinesia and rigidity. Usually, neurologists regularly monitor fluctuations using MDS-UPDRS part III clinical scale. Nevertheless, to have more objective quantitative evaluation, it possible assess cardinal PD wearable sensors portable robotic devices. Unfortunately while there are several research papers...
This work focuses on the design and validation of a wearable mechatronic device for an at-home assessment wrist stiffness in patients affected by Parkinson's Disease (PD). The includes one actuated joint four passive revolute joints with high overall intrinsic backdriveability. In order to allow user freely move during activities daily living, we implemented transparent controller basis interaction force sensed embedded load cell. Conversely, provide perturbations estimating...
Epidemiological studies have consistently shown an inverse association between cigarette smoking and Parkinson's disease. Literature indicates that both current former smokers a reduced risk of developing PD compared to non-smokers. If protects against disease or, conversely, habit is abated due the itself, according reverse causation, still unsolved question.