A5038014998- Migraine and Headache Studies
- Trigeminal Neuralgia and Treatments
- Olfactory and Sensory Function Studies
- Ophthalmology and Eye Disorders
- Cardiovascular Syncope and Autonomic Disorders
- Parkinson's Disease Mechanisms and Treatments
- Maternal Mental Health During Pregnancy and Postpartum
- Sympathectomy and Hyperhidrosis Treatments
- Neurological disorders and treatments
- Cerebral Venous Sinus Thrombosis
- Neurological Complications and Syndromes
- Genetic Neurodegenerative Diseases
- Neurological Disorders and Treatments
- Psychosomatic Disorders and Their Treatments
- Botulinum Toxin and Related Neurological Disorders
- Heart Rate Variability and Autonomic Control
- Biochemical effects in animals
- Neuroscience of respiration and sleep
- Neuroscience and Neuropharmacology Research
- Restraint-Related Deaths
- Traumatic Brain Injury and Neurovascular Disturbances
- Eicosanoids and Hypertension Pharmacology
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
Women's College Hospital
2018-2024
University of Toronto
2016-2024
John Wiley & Sons (United States)
2023
Hudson Institute
2023
Deleted Institution
2023
Toronto Western Hospital
2016-2018
Montreal Neurological Institute and Hospital
2012
McGill University
2012
Brain imaging techniques that use vascular signals to map changes in neuronal activity rely on the coupling between electrophysiology and hemodynamics, a phenomenon referred as “neurovascular coupling” (NVC). It is unknown whether this relationship remains reliable under altered brain states associated with acetylcholine (ACh) levels, such attention arousal pathological conditions Alzheimer's disease. We therefore assessed effects of varying ACh tone whisker-evoked NVC responses rat barrel...
Abstract Objective To evaluate changes in interictal burden with galcanezumab versus placebo patients episodic (EM) or chronic migraine (CM). Background The disruptive effects of occur both during attacks (ictal period) and between (interictal period), affecting work, school, family, social life. Migraine clinical trials typically assess ictal endpoints, neglecting burden. Methods CONQUER was a 3‐month, double‐blind study that randomized adult EM CM who had experienced failure two to four...
Activation of the basal forebrain (BF), primary source acetylcholine (ACh) in cortex, broadly increases cortical cerebral blood flow (CBF), a response downstream to ACh release. Although endothelial nitric oxide and cholinoceptive GABA (γ-aminobutyric acid) interneurons have been implicated, little is known about role pyramidal cells this their possible interaction with astrocytes. Using c-Fos immunohistochemistry as marker neuronal activation laser-Doppler flowmetry, we measured changes CBF...
ABSTRACT Objective: We have updated the migraine prevention guideline of Canadian Headache Society from 2012, as there are new therapies available, and additionally, we provided guidelines for chronic migraine, which was not addressed in previous iteration. Methods: undertook a systematic review to identify studies since last guideline. For identified, performed data extraction subsequent meta-analyses where possible. composed summary evidence found modified Delphi recommendation process....
Migraine significantly impacts individuals from all walks of life and around the globe. Chronic or high-frequency episodic migraine has similar disability burden on healthcare system can be challenging to manage. The focus this article is provide an outline available pharmacological nonpharmacological evidence-based strategies that clinicians employ build a "toolbox" for their patients.
Adverse childhood experiences (ACEs) are a risk factor for progression from episodic to chronic migraine. Risk factors medication overuse headache (MOH) incompletely understood, but opioid may carry higher than of other types. We performed retrospective chart review investigating the frequency and impact ACEs in patients with MOH. Of 68 included patients, 37 (54.4%) reported ACEs. There was no significant inter-group difference baseline migraine disability assessment (MIDAS) or monthly days....
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Objective: We sought to identify clinical or surgical characteristics predicting response deep brain stimulation (DBS) for tremor, hypothesizing that medication and/or alcohol responsiveness might correlate with good outcome. Background: Tremor is a common and disabling feature of many disorders. Medical therapy tremor often ineffective, factors DBS are poorly characterized. We examined patients obtaining the most benefit from DBS. Methods: performed retrospective chart review all who...
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