A5041879748- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Childhood Cancer Survivors' Quality of Life
- Acute Myeloid Leukemia Research
- Blood disorders and treatments
- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Genetic factors in colorectal cancer
- Immunodeficiency and Autoimmune Disorders
- Neutropenia and Cancer Infections
- Blood Coagulation and Thrombosis Mechanisms
- Sarcoma Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Cancer Genomics and Diagnostics
- Antifungal resistance and susceptibility
- Immune Cell Function and Interaction
- DNA Repair Mechanisms
- Fungal Infections and Studies
- Neonatal Health and Biochemistry
- Autoimmune and Inflammatory Disorders Research
- Parvovirus B19 Infection Studies
- Histiocytic Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Polyomavirus and related diseases
Tel Aviv Sourasky Medical Center
2016-2025
Tel Aviv University
2016-2025
Schneider Children's Medical Center
2012-2023
Palmetto Hematology Oncology
2003-2018
Montreal Children's Hospital
2016
Hospital for Sick Children
2016
SickKids Foundation
2016
Rambam Health Care Campus
2001-2013
Meyer Children's Hospital
2002-2013
Hadassah Medical Center
2013
Recurrent glioblastoma multiforme (GBM) is incurable with current therapies. Biallelic mismatch repair deficiency (bMMRD) a highly penetrant childhood cancer syndrome often resulting in GBM characterized by high mutational burden. Evidence suggests that mutation and neoantigen loads are associated response to immune checkpoint inhibition.We performed exome sequencing prediction on 37 bMMRD cancers compared them adult brain neoplasms. Neoantigen was responsive from multiple tissues. Two...
Upon activation, neutrophils release fibers composed of chromatin and neutrophil proteins termed extracellular traps (NETs). NETs trap kill microbes, activate dendritic cells T cells, are implicated in autoimmune vascular diseases. Given the growing interest role cancer immunoediting diverse function NETs, we searched for by tumor-associated (TANs). Using pediatric Ewing sarcoma (ES) as a model, retrospectively examined histopathological material from diagnostic biopsies eight patients (mean...
Haematopoietic stem cell transplantation has been proposed as treatment for mitochondrial neurogastrointestinal encephalomyopathy, a rare fatal autosomal recessive disease due to TYMP mutations that result in thymidine phosphorylase deficiency. We conducted retrospective analysis of all known patients suffering from encephalomyopathy who underwent allogeneic haematopoietic between 2005 and 2011. Twenty-four patients, 11 males 13 females, median age 25 years (range 10–41 years) treated with...
Xenotransplantation of pig tissues has great potential to overcome the shortage organ donors. One approach address vigorous immune rejection associated with xenotransplants is use embryonic precursor tissue, which induces and utilizes host vasculature upon its growth development. Recently, we showed in mice that pancreatic tissue from day 42 (E42) exhibits optimal properties as a β cell replacement therapy. We now demonstrate proof concept 2 diabetic Cynomolgus monkeys, followed for 393 280...
Forty-one consecutive children with acute lymphoblastic leukemia (ALL) received prophylaxis therapy the low molecular weight heparin (LMWH) enoxaparin during l-asparaginase treatment. Enoxaparin was given every 24 h subcutaneously at a median dose of 0.84 mg/kg per day (range, 0.45–1.33 day) starting first until 1 week after last dose. Molecular analysis for thrombophilic polymorphisms documented prothrombin G20210A mutation in 3/27 (11%), homozygosity MTHFR C677T 5/27 (18.5%, and...
Background Inherited bone marrow failure syndromes are rare genetic disorders characterized by failure, congenital anomalies, and cancer predisposition. Available single disease registries provide reliable information regarding natural history, efficacy side effects of treatments, contribute to the discovery causative genes. However, these could not shed light on true incidence various syndromes. We, therefore, established an Israeli national registry in order investigate relative frequency...
Purpose Osteosarcoma (OS), the most common primary bone malignancy in childhood poses a therapeutic challenge despite extensive research. Neutrophil extracellular traps (NETs) play role tumor microenvironment (TME) variety of cancers, but their OS has not been characterized. Experimental Design This retrospective cohort study aimed to investigate immune cell infiltration and NETs formation patients with its association chemotherapy response overall survival using immunofluorescence...
Abstract Although a relatively small number of previous studies suggest modest response to hydroxyurea (HU) therapy in β‐thalassemia, more recent investigations have revealed that some transfusion‐dependent patients can become transfusion‐independent following HU therapy. Patients with Gγ XmnI polymorphism, several β‐globin mutations, and α‐thalassemia deletions were inconsistently reported significant responses To better predict who may respond, we retrospectively evaluated the clinical...
To evaluate the quality of stromal bed and safety on endothelium in preparation donor tissue for Descemet stripping automated endothelial keratoplasty a masked fashion using 2 mechanical microkeratomes femtosecond laser.Deep anterior lamellar dissection was performed 15 corneas. Central cell density calculated specular microscopy before after dissection. One cornea from each 5 pairs cut with Moria ALTK system CBm microkeratome 300-μm head mate Horizon disposable microkeratome. Five...
Neutrophil extracellular traps (NETs) are fibers composed of chromatin and neutrophil proteins released by activated neutrophils. NETs trap kill microbes, activate dendritic T cells, implicated in autoimmune vascular diseases. The pathogenesis inflammatory bowel disease (IBD) is multifactorial characterized chronic active mucosal inflammation with controversial contribution Our aim to describe the involvement pediatric IBD. We retrospectively examined biopsies from small colon children at...
Hereditary biallelic mismatch repair deficiency (BMMRD) is caused by mutations in the (MMR) genes and manifests features of neurofibromatosis type 1, gastrointestinal (GI) polyposis, GI, brain, hematological cancers. This first study to characterize GI phenotype BMMRD using both retrospective prospective surveillance data.The International Consortium was created collect information on families referred from around world. All patients had germline MMR or lack protein staining normal tumor...
Background Busulfan (BU), often used in high dose for myeloablation before hematopoietic stem cell transplantation (HSCT), has been implicated certain HSCT toxicities, including the occurrence of hepatic veno-occlusive disease (HVOD). In addition to weight and age, gene polymorphisms specific members glutathione-transferase (GST) family (A1, P1, M1, T1), involved BU metabolism, may play a role wide inter-patient variability systemic concentrations. Procedure The present study integrated...
Prolonged cytopenias are a non-specific sign with wide differential diagnosis. Among inherited disorders, predisposing to leukemia require timely and accurate diagnosis ensure appropriate medical management, including adequate monitoring stem cell transplantation prior the development of leukemia. We aimed define types prevalences genetic causes leading persistent in children. The study comprises children cytopenias, myelodysplastic syndrome, aplastic anemia, or suspected bone marrow failure...
BACKGROUND The purposes of the study were to evaluate prospectively nutritional status children with solid tumors who receiving chemotherapy, find most sensitive parameter protein energy malnutrition, and determine whether stage disease aggressiveness chemotherapy have any influence on status. METHODS Fifty patients followed from time diagnosis throughout chemotherapy. Serum albumin, prealbumin, weight measured at before each course RESULTS At diagnosis, only 2.7% had albumin levels < 3.5...
Data on the clinical presentation of constitutional mismatch repair deficiency syndrome (CMMRD) is accumulating. However, as extraintestinal manifestations are often fatal and occur at early age, data systematic evaluation gastrointestinal tract scarce. Here we describe 11 subjects with verified biallelic carriage who underwent colonoscopy, upper endoscopy small bowel evaluation. Five were symptomatic in six findings screen detected. Two had colorectal cancer few adenomatous polyps (19, 20...