A5088334198- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Renal cell carcinoma treatment
- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Urinary Bladder and Prostate Research
- Hormonal and reproductive studies
- Urologic and reproductive health conditions
- Cancer Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Extracellular vesicles in disease
- Renal and related cancers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Screening and Detection
- Epigenetics and DNA Methylation
- Abdominal vascular conditions and treatments
- Cardiovascular Syncope and Autonomic Disorders
- Cancer Immunotherapy and Biomarkers
- Genital Health and Disease
- Metabolomics and Mass Spectrometry Studies
Hospital de Basurto
2015-2025
Centro de Investigación Biomédica en Red de Cáncer
2017-2024
BioCruces Health research Institute
2023-2024
CIC bioGUNE
2024
Encore Pharmaceuticals (United States)
2024
Clinic IMQ Zorrotzaurre
2022
University of the Basque Country
2009-2021
Hospital de Cruces
2017
Osakidetza
2015
Asociación Española de Urología
2008-2013
Bacillus Calmette-Guerin is the most effective therapy for nonmuscle invasive bladder cancer. Recently to calculate risks of recurrence and progression based on data from 7 European Organisation Research Treatment Cancer trials a scoring system was reported. However, in that series only 171 patients were treated with bacillus Calmette-Guerin. We developed risk stratification model provide accurate estimates probability after Calmette-Guerin.Data analyzed 1,062 included 4 Spanish Urological...
Abstract Newly growing evidence highlights the essential role that epitranscriptomic marks play in development of many cancers; however, little is known about and implications altered epitranscriptome deposition prostate cancer. Here, we show transfer RNA N 7 -methylguanosine (m G) transferase METTL1 highly expressed primary advanced tumours. Mechanistically, find depletion causes loss m G tRNA methylation promotes biogenesis a novel class small non-coding RNAs derived from 5'tRNA fragments....
Urine sample analysis is irreplaceable as a non‐invasive method for disease diagnosis and follow‐up. However, in urine samples, non‐degraded protein RNA may be only found urinary extracellular vesicles (uEVs). In recent years, various methods of uEV enrichment using low volumes unsophisticated equipment have been developed, with variable success. We compared the results differential ultracentrifugation procedure 4 these methods. The tested were lectin‐based purification, Exoquick (System...
Urine contains extracellular vesicles (EVs) that concentrate molecules and protect them from degradation. Thus, isolation characterisation of urinary EVs could increase the efficiency biomarker discovery. We have previously identified proteins RNAs with differential abundance in prostate cancer (PCa) patients compared to benign hyperplasia (BPH). Here, we focused on analysis metabolites contained collected PCa BPH. Targeted metabolomics was performed by ultra-high-performance liquid...
// Felix Royo 1, 2, * , Patricia Zuñiga-Garcia Verónica Torrano Ana Loizaga 3, Pilar Sanchez-Mosquera 1 Aitziber Ugalde-Olano 4 Esperanza González R. Cortazar Laura Palomo Sonia Fernández-Ruiz Isabel Lacasa-Viscasillas 3 Maria Berdasco 5 James D. Sutherland Rosa Barrio Amaia Zabala-Letona Natalia Martín-Martín Arruabarrena-Aristorena Lorea Valcarcel-Jimenez Alfredo Caro-Maldonado Jorge Gonzalez-Tampan Guido Cachi-Fuentes Manel Esteller M. Aransay 2 Miguel Unda Juan Falcón-Pérez 6, Ω Arkaitz...
To evaluate change in quality of life (QoL) and symptoms patients with lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH) conditions current clinical practice. Prospective, longitudinal, multicenter open-label study was carried out urology outpatient clinics. Patients were ≥40 years age an International Prostate Symptom Score (IPSS) score ≥8. QoL measured at baseline 6 months using the Benign Prostatic Hyperplasia Impact Index (BII) IPSS. 1713 included for analysis. Mean...
(1). Background: Immunohistochemical (IHC) evaluation of programmed death-1 (PD-1) and its ligand (PD-L1) is being used to evaluate advanced malignancies with potential response immune checkpoint inhibitors. We evaluated both plasma tissue expression PD-1 PD-L1 in the same cohort patients, including non-metastatic metastatic clear cell renal carcinoma (CCRCC). Concomitant was emphasis on diagnostic prognostic implications. (2) Methods: we analyzed IHC tumor tissues soluble forms (sPD-1...
Bladder cancer is one of the most common cancers and, together with prostate carcinoma, accounts for majority malignancies genitourinary tract. Since prognosis ameliorates early detection, it will be beneficial to have a repertoire diagnostic markers that could complement current diagnosis protocols. Recently, cell-secreted extracellular vesicles received great interest as source low invasive disease biomarkers because they are found in many body fluids, including urine. The work describes...
Urine extracellular vesicles are a valuable low-invasive source of information, especially for the cells genitourinary tract. In search biomarkers, different techniques have been developed to isolate and characterize cargo these vesicles. present work, we compare five isolation methods (three commercial kits, ultracentrifugation, lectin-based purification) perform miRNA profiling using multiplex assay. The results showed high correlation through all techniques, 48 out 68 miRNAs were detected...
Among the extensive genomic alterations in prostate cancer, deletion of PTEN stands out as one most consistently observed and confirmed alteration. loss tumors is primarily associated with cancer cell proliferation survival through activation PI3K-AKT-mTOR signalling pathway. However, its use a robust biomarker clinical practice hampered by complex epigenetic, transcriptional post-translational regulation. Here, we undertook an approach that combined situ assessment protein surrogates...
We estimate the annual incidence of bladder cancer in Spain and describe clinical profile patients with enrolled a population based study.Using structure Spanish National Health System as basis, 2011 AEU (Spanish Association Urology) conducted this study representative sample from 26 public hospitals reference 10,146,534 inhabitants, comprising 21.5% population.A total 4,285 episodes were diagnosed, which 2,476 (57.8%) new cases 1,809 (42.2%) recurrence, representing an estimated 11,539...
The discovery of the intrarenal renin-angiotensin system (iRAS), which regulates angiogenesis, cell differentiation and proliferation, has opened new perspectives in knowledge kidney carcinogenesis. In this study we analyzed immunohistochemical expression fluorimetric activity four key peptidases iRAS tumor tissue (n = 144) serum samples 128) from patients with renal neoplasms. Neutral endopeptidase (NEP/CD10), Angiotensin-converting enzyme-2 (ACE2), aminopeptidase A (APA) were expressed...
Lipid imaging mass spectrometry (LIMS) has been tested in several pathological contexts, demonstrating its ability to segregate and isolate lipid signatures complex tissues, thanks the technique's spatial resolution. However, it cannot yet compete with superior identification power of high-performance liquid chromatography coupled (HPLC-MS), therefore, very often, latter is used refine assignment species detected by LIMS. Also, not clear if differences sensitivity resolution between two...
Several studies have proposed that protease expression and activity may a predictive value in the survival of clear cell renal carcinoma (CCRCC). Most efforts on this issue been focused analysis matrix metalloproteinases (MMP) very little role other proteases, such as peptidases. The catalytic 9 peptidases (APN, APB, ASP, CAP, DPP-IV, NEP/CD10, PEP, PGI, PSA) was quantified by fluorometric methods series 79 CCRCC patients, results obtained were analyzed for (Kaplan-Meier curves, log-rank...