A5036244378- Neuropeptides and Animal Physiology
- Peptidase Inhibition and Analysis
- Regulation of Appetite and Obesity
- Neuroscience and Neuropharmacology Research
- Pharmacological Receptor Mechanisms and Effects
- Neuroscience of respiration and sleep
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Hormonal Regulation and Hypertension
- Neuroendocrine Tumor Research Advances
- Adipose Tissue and Metabolism
- Stress Responses and Cortisol
- Genetics and Neurodevelopmental Disorders
- Biochemical Analysis and Sensing Techniques
- Sleep and Wakefulness Research
- Eating Disorders and Behaviors
- Pharmaceutical Practices and Patient Outcomes
- Pancreatic function and diabetes
- Nicotinic Acetylcholine Receptors Study
- Biochemical effects in animals
- Pain Mechanisms and Treatments
- Higher Education Teaching and Evaluation
- Circadian rhythm and melatonin
- Renin-Angiotensin System Studies
- Hypothalamic control of reproductive hormones
University of the Basque Country
2015-2025
Centro de Investigación Biomédica en Red de Salud Mental
2012-2023
Instituto de Salud Carlos III
2020-2023
Purpose: Physical activity training programs in older adults have recognized health benefits. Evidence suggests that should include a combination of progressive resistance, balance, and functional training. Our aim was to assess the effects simple physical program working on strength, flexibility, cardiovascular fitness, balance adults, as well detraining period, at various different ages. Methods: This longitudinal prospective study, including convenience sample 227 independent (54 men, 173...
Serum peptidases, such as angiotensin-converting enzyme (ACE), enzyme-2 (ACE2), neutral endopeptidase (NEP), aminopeptidase N (APN), and A (APA), are important elements of the renin–angiotensin system (RAS). Dysregulation these enzymes has been associated with hypertension cardiovascular risk. In present study, serum activities RAS peptidases were analyzed to evaluate existence sexual differences, a possible different pattern in pre- post-andropausal/post-menopausal participants. One hundred...
(1). Background: Immunohistochemical (IHC) evaluation of programmed death-1 (PD-1) and its ligand (PD-L1) is being used to evaluate advanced malignancies with potential response immune checkpoint inhibitors. We evaluated both plasma tissue expression PD-1 PD-L1 in the same cohort patients, including non-metastatic metastatic clear cell renal carcinoma (CCRCC). Concomitant was emphasis on diagnostic prognostic implications. (2) Methods: we analyzed IHC tumor tissues soluble forms (sPD-1...
Abstract G‐protein inwardly rectifying potassium (GIRK) channels mediate the synaptic actions of numerous neurotransmitters in mammalian brain and play an important role regulation neuronal excitability most regions through activation various G‐protein‐coupled receptors such as serotonin 5‐HT 1A receptor. In this report we describe localization GIRK1, GIRK2, GIRK3 subunits receptor rat brain, assessed by immunohistochemistry situ hybridization. We also analyze co‐expression GIRK with cell...
We analyze the outcome on testosterone (T) and cortisol (C) responses in 12 professional basketball players during a season of competition. Serum adrenocorticotropic hormone (ACTH), C, total (TT), free (FT) levels were analyzed October, December, March, April. A day after games, blood samples taken. ACTH maintained at initial season. However, basal C significantly changed season, with lower December Basal serum TT increased until maximum March. No differences presented values FT high October...
Purpose: It is well established that the COVID-19 pandemic has increased incidence of depressive symptoms in general population. So far, there are no studies analyzing how this affected prescription antidepressants. Methods: We retrospectively estimated new cases depression by prescriptions antidepressive agents over a period 6 years distributed three periods 2 each: pre-pandemic, pandemic, and post-pandemic, running from March 2018 to February 2024. This research was conducted healthcare...
Colorectal cancer (CRC) is a major health problem in elderly people because of its high incidence and mortality rate.Despite early screening programs, more than half CRC patients are diagnosed at advanced stages.Fibroblast activation protein-α (FAP) expression cancer-associated fibroblasts (CAFs) has been associated with higher risk metastases poor survival.Here, we have analyzed the immunohistochemical FAP 41 adenoma-carcinoma sequences.In addition, was individually combination β-catenin...
(1) Background: Renal cell carcinoma (RCC) is a heterogeneous and complex disease with only partial response to therapy, high incidence of metastasis recurrences, scarce reliable biomarkers indicative progression survival. Cancer-associated fibroblasts (CAFs) play an important role supporting promoting renal cancer progression. (2) Methods: In this study, we analysed fibroblast activation protein-α (FAP) immunohistochemical expression its soluble isoform (sFAP) in tumour tissues plasma from...
Abstract Objective: To test the effect of raising ambient temperature (AT) on activity‐based anorexia (ABA) and to extend female rats previous findings reported in male animals. Method: Two studies are which were submitted food restriction free access an activity wheel either separately or combination under changing (21–32°C) constant AT (21°C). Results: Warming ABA animals reversed running activity, preserved food‐intake, enabled recover from acute weight loss. Moreover, sedentary...
Abstract Objective: The aim of this work was to study the potential involvement neuropeptide Y (NPY) and orexins in anorexigenic mechanism fluoxetine obese Zucker rats, assessing effects chronic treatment on NPY orexin immunostaining several hypothalamic regions. Research Methods Procedures: Male ( fa/fa ) rats were administered (10 mg/kg intraperitoneally) daily for 2 weeks. control group 0.9% NaCl solution. Carcass composition assessed using official methods Association Official Analytical...