A5028243133- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Lymphoma Diagnosis and Treatment
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Renal and related cancers
- Advanced biosensing and bioanalysis techniques
- Cancer-related gene regulation
- Vector-borne infectious diseases
- Helicobacter pylori-related gastroenterology studies
- Chronic Lymphocytic Leukemia Research
- Biosensors and Analytical Detection
- Cytokine Signaling Pathways and Interactions
- Ubiquitin and proteasome pathways
- Extracellular vesicles in disease
- Wnt/β-catenin signaling in development and cancer
- Multiple Myeloma Research and Treatments
- Toxin Mechanisms and Immunotoxins
- Immune Cell Function and Interaction
- RNA Research and Splicing
- Molecular Biology Techniques and Applications
- Peptidase Inhibition and Analysis
- Cancer, Lipids, and Metabolism
Ikerbasque
2016-2025
University of Oxford
2016-2025
Shanghai University
2023-2025
Onkologikoa
2019-2025
Biogipuzkoa Health Research Institute
2015-2024
Molecular Oncology (United States)
2016-2021
John Radcliffe Hospital
2009-2021
Institute of Molecular Medicine
2021
Jewish Hospital
2021
Barnes-Jewish Hospital
2021
Circulating nucleic acids have been shown to potential as non-invasive diagnostic markers in cancer. We therefore investigated whether microRNAs also utility by comparing levels of tumour-associated MIRN155 (miR-155), MIRN210 (miR-210) and MIRN21 (miR-21) serum from diffuse large B-cell lymphoma (DLBCL) patients (n = 60) with healthy controls 43). Levels were higher patient than control sera (P 0.009, 0.02 0.04 respectively). Moreover, high expression was associated relapse-free survival...
Abstract Diffuse large B cell lymphoma (DLBCL) is an aggressive malignancy that accounts for nearly 40% of all lymphoid tumors. This heterogeneous disease can be divided into germinal center cell‐like (GCB) and activated (ABC) subtypes by gene expression immunohistochemical profiling. Using microarray analysis on prototypic lines, we identified microRNAs ( miR‐155 , miR‐21 miR‐221 ) were more highly expressed in ABC‐type than GCB‐type lines. These over‐expressed de novo DLBCL n = 35),...
MicroRNAs are naturally occurring small RNA species that regulate gene expression and frequently abnormally expressed in cancers. However, the role of microRNAs lymphoma is poorly understood. Therefore, we undertook a comprehensive study microRNA two most common lymphomas: diffuse large B-cell (DLBCL) (n = 80) follicular (FCL) 18) using microarrays containing probes for 464 human microRNAs. Unsupervised cluster analysis revealed distinct patterns between these lymphomas specific signatures...
The transcriptome of the CD34+ cells was determined in a group 10 patients with 5q- syndrome using comprehensive array platform, and compared from 16 healthy control subjects 14 refractory anaemia normal karyotype. majority genes assigned to commonly deleted region (CDR) at 5q31-q32 showed reduction expression levels syndrome, consistent loss one allele. Candidate showing haploinsufficiency included tumour suppressor gene SPARC RPS14, component 40S ribosomal subunit. Two mapping CDR, RBM22...
Abstract Gastric cancer remains one of the leading causes global mortality due to therapy resistance, with Helicobacter pylori (H. pylori) infection being a major risk factor. In this study, we report significance an elevation stem cell regulator SOX9 in bacteria-infected human gastritis and samples, paralleling increased levels TNFα. was more intense specimens containing pathogenically significant cagA+ strains H. pylori. Notably, found that required for bacteria-induced gastric...
The tumor microenvironment (TME) is reprogrammed by cancer cells and participates in all stages of progression. contribution stromal to the reprogramming TME not well understood. Here, we provide evidence role cytokine oncostatin M (OSM) as central node for multicellular interactions between immune nonimmune epithelial cell compartment. OSM receptor (OSMR) deletion a multistage breast model halted We ascribed causality function axis demonstrating reduced burden syngeneic tumors implanted...
Research over the last few years has demonstrated increasing role of microRNAs (miRNAs) as major regulators gene expression in diverse cellular processes and diseases. Several viruses, particularly herpesviruses, also use miRNA pathway regulation by encoding their own miRNAs. Marek's disease (MD) is a widespread lymphomatous neoplastic poultry caused highly contagious virus type 1 (MDV-1). Recent studies using virus-infected chicken embryo fibroblasts have identified at least eight miRNAs...
Control of West Nile virus (WNV) can only be effective if the vectors and reservoirs are identified controlled. Although mosquitoes primary vectors, WNV has repeatedly been isolated from ticks. Therefore, tick-borne transmission studies were performed with an ixodid (Ixodes ricinus) argasid tick species (Ornithodoros moubata). Both became infected after feeding upon viremic hosts, but I. ricinus ticks unable to maintain virus. In contrast, O. moubata for at least 132 days, infection was...
ABSTRACT MicroRNAs (miRNAs) are increasingly being recognized as major regulators of gene expression in many organisms, including viruses. Among viruses, members the family Herpesviridae account for majority currently known virus-encoded miRNAs. The highly oncogenic Marek's disease virus type 1 (MDV-1), an avian herpesvirus, has recently been shown to encode eight miRNAs clustered MEQ and LAT regions viral genome. genus Mardivirus , which MDV-1 belongs, also includes nononcogenic but...
Abstract Background MicroRNAs are small RNA species that regulate gene expression post-transcriptionally and aberrantly expressed in many cancers including hematological malignancies. However, the role of microRNAs pathogenesis multiple myeloma (MM) is only poorly understood. We therefore used microarray analysis to elucidate complete miRNome (miRBase version 13.0) purified tumor (CD138 + ) cells from 33 patients with MM, 5 monoclonal gammopathy undetermined significance (MGUS) 9 controls....
Deregulation of microRNA (miRNA) expression has been documented in diffuse large B-cell lymphoma (DLBCL). However, the impact miRNAs and their machinery DLBCL is not fully determined. Here, we assessed role miRNA processing genes development. Using microarray RT-qPCR approaches, quantified global core components miRNA-processing 75 DLBCLs (56 de novo 19 transformed) 10 lymph nodes (LN). Differential signatures were identified between LNs, or transformed DLBCLs. We also subsets associated...