A5002144908- Cytokine Signaling Pathways and Interactions
- Immune cells in cancer
- Chemokine receptors and signaling
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- Immune Cell Function and Interaction
- Inflammasome and immune disorders
Biogipuzkoa Health Research Institute
2020-2023
The tumor microenvironment (TME) is reprogrammed by cancer cells and participates in all stages of progression. contribution stromal to the reprogramming TME not well understood. Here, we provide evidence role cytokine oncostatin M (OSM) as central node for multicellular interactions between immune nonimmune epithelial cell compartment. OSM receptor (OSMR) deletion a multistage breast model halted We ascribed causality function axis demonstrating reduced burden syngeneic tumors implanted...
Inflammasomes are cytosolic signaling hubs that promote the inflammatory response (i.e. an immune reaction to counteract threats in physiological conditions). Their potential role lymphomagenesis remains be elucidated. Depending on context, innate cells, such as macrophages, may induce inflammation contributes anti-tumor function; however, if uncontrolled, can cancer development. Here, we exploited bioinformatic tools, TCGA data, and tumor tissue samples from patients with diffuse large...
Abstract Cancer cells are constantly communicating with the surrounding tumour microenvironment (TME) and they hijack physiological cell interactions to overcome immune system surveillance promote cancer progression 1,2 . However, contribution of stromal reprogramming TME is not well understood. In this study we provide unprecedented evidence role cytokine Oncostatin M (OSM) as central node for multicellular between non-immune stroma epithelial compartment. We show that expression...