A5044610098- Virus-based gene therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer Research and Treatments
- RNA Interference and Gene Delivery
- CAR-T cell therapy research
- Colorectal Cancer Screening and Detection
- Muscle Physiology and Disorders
- Radiomics and Machine Learning in Medical Imaging
- AI in cancer detection
- Viral gastroenteritis research and epidemiology
- Cancer-related molecular mechanisms research
- Viral Infections and Immunology Research
- Herpesvirus Infections and Treatments
- CRISPR and Genetic Engineering
- Immunotherapy and Immune Responses
- Data-Driven Disease Surveillance
- Artificial Intelligence in Healthcare
- Cancer Genomics and Diagnostics
- Statistical Methods in Epidemiology
- Forensic and Genetic Research
- Cell death mechanisms and regulation
- Cytomegalovirus and herpesvirus research
- Extracellular vesicles in disease
- Prostate Cancer Treatment and Research
- Optical Coherence Tomography Applications
Ikerbasque
2021-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2024
Bioef - Fundación Vasca de Innovación e Investigación Sanitarias
2006-2021
Universitat Pompeu Fabra
2020
University of Pittsburgh
2003-2008
Zero to Three
2004
Universidad de Navarra
1995-2001
Urine sample analysis is irreplaceable as a non‐invasive method for disease diagnosis and follow‐up. However, in urine samples, non‐degraded protein RNA may be only found urinary extracellular vesicles (uEVs). In recent years, various methods of uEV enrichment using low volumes unsophisticated equipment have been developed, with variable success. We compared the results differential ultracentrifugation procedure 4 these methods. The tested were lectin‐based purification, Exoquick (System...
The use of gene therapy to enhance antitumor immunity has emerged as a promising procedure fight cancer. In this study we have tested the ability an adenovirus carrying interleukin 12 (IL–12) (AdCMVIL–12) eliminate tumoral lesions in 3 animal models orthotopic hepatocellular carcinoma (HCC). Intratumoral injection AdCMVIL–12 animals with single big tumor nodule implanted liver resulted significant inhibition growth dose–dependent manner. Fifty percent that received dose 5 × 10 9...
Although deep learning pathology diagnostic algorithms are proving comparable results with human experts in a wide variety of tasks, they still require huge amount well annotated data for training. Generating such extensive and labelled datasets is time consuming not feasible certain tasks so, most the medical available scarce images therefore, enough In this work we validate that use few shot techniques can transfer knowledge from defined source domain Colon tissue into more generic...
Colorectal cancer is one of the world leading death causes. Fortunately, an early diagnosis allows for effective treatment, increasing survival rate. Deep learning techniques have shown their utility adenoma detection rate at colonoscopy, but a dataset usually required so model can automatically learn features that characterize polyps. In this work, we present PICCOLO dataset, comprises 3433 manually annotated images (2131 white-light 1302 narrow-band images), originated from 76 lesions 40...
The popularization of mobile health (mHealth) apps for public or medical care purposes has transformed human life substantially, improving lifestyle behaviors and chronic condition management. objective this study is to evaluate the effect gamification features in a mHealth app that includes most common categories behavior change techniques self-report data. data reported by user can be manual (i.e., diet, activity, weight) automatic (Fitbit wearable devices). As secondary objective, work...
We have analyzed the ability of a recombinant replication-defective adenovirus to transfer thymidine kinase gene herpes simplex virus (HSV-tk) into hepatocellular carcinoma (HCC) cells confer sensitivity ganciclovir. Three HCC cell lines (Hep3B, PLC/PRF/5, and HepG2) were efficiently infected in vitro by carrying lacZ reporter (AdCMVlacZ). Expression HSV-tk with (AdCMVtk) induced ganciclovir dose-dependent manner. A bystander killing effect was observed when 90% uninfected tumor mixed only...
In rats with diethylnitrosamine (DENA)-induced hepatocellular carcinoma (HCC), we studied in vivo gene transfer efficiency using intraportal injections of recombinant adenovirus carrying the lacZ reporter (AdCMVlacZ) and therapeutic efficacy adenovirus-mediated thymidine kinase herpes simplex virus (HSV-tk) followed by ganciclovir (GCV) administration. DENA was very effective inducing HCC but also stimulated nontumor cell replication, as shown proliferating nuclear antigen (PCNA) staining....
Metabolizing enzymes, which often display genetic polymorphisms, are involved in the activation of compounds present tobacco smoke that may be relevant to gastric carcinogenesis. We report results a study looking at association between risk adenocarcinoma and polymorphisms genes CYP1A1, CYP1A2, EPHX1, GSTT1. A nested case-control was carried out within European Prospective Investigation into Cancer Nutrition, developed 10 countries. The includes 243 newly diagnosed cases histologically...
With the rapid spread of COVID-19 pandemic, novel Meaningful Integration Data Analytics and Services (MIDAS) platform quickly demonstrates its value, relevance transferability to this new global crisis. The MIDAS enables connection a large number isolated heterogeneous data sources, combines rich datasets including open social data, ingesting preparing these for application analytics, monitoring research tools. These platforms will assist public health author ities in: (i) better...
Point mutations in the α-synuclein coding gene may lead to development of Parkinson's disease (PD). PD is often accompanied by other psychiatric conditions, such as anxiety, depression, and drug use disorders, which typically emerge adulthood. Some these point mutations, SNCA A30T, have been linked behavioral effects that are not commonly associated with PD, especially regarding alcohol consumption patterns. In this study, we investigated whether familial mutation A53T changes behavior...
The European Prospective Investigation into Cancer and nutrition (EPIC) is a long-term, multi-centric prospective study in Europe investigating the relationships between cancer nutrition. This has served as basis for number of Genome-Wide Association Studies (GWAS) other types genetic analyses. Over period 5 years, 52,256 EPIC DNA samples have been extracted using an automated extraction platform. Here we evaluated pre-analytical factors affecting yield, including anthropometric,...
Modern photonic technologies are emerging, allowing the acquisition of in-vivo endoscopic tissue imaging at a microscopic scale, with characteristics comparable to traditional histological slides, and label-free modality. This raises possibility an `optical biopsy' aid clinical decision making. approach faces barriers for being incorporated into practice, including lack existing images training, unfamiliarity clinicians novel image domains uncertainty trusting `black-box' machine learned...
Abstract Background The increasing prevalence of childhood obesity makes it essential to study the risk factors with a sample representative population covering more health topics for better preventive policies and interventions. It is aimed develop an ensemble feature selection framework large-scale data identify good interpretability clinical relevance. Methods We analyzed collected from 426,813 children under 18 during 2000–2019. A BMI above 90th percentile same age gender was defined as...
We previously reported that systemic injection of recombinant adenovirus resulted in a rim gene transduction around experimental liver tumor nodules. This zone higher infection is dependent on the αvβ3 integrin, acting as an internalization receptor, which overexpressed tissues surrounding metastases. When encoding interleukin-12 (AdCMVIL-12) given into subcutaneous nodule mice also bearing concomitant tumors, fraction AdCMVIL-12 reaches circulation and infects tissue, especially at...
Adenoviral-associated viral vectors (AAV) have shown significant promise for efficient gene delivery to multiple tissues. Studies of different serotypes AAV revealed expression patterns provided by in postnatal mice. Previous utero studies serotype 2 (AAV2) demonstrated certain fetal tissues depending on route administration. We studied the pattern from 1 (AAV1) using intramuscular, intraperitoneal, and intravascular routes administration embryonic day 16 C57BL/6 Limb skeletal muscle...