A5025720471- Alkaloids: synthesis and pharmacology
- Traditional and Medicinal Uses of Annonaceae
- Chemical synthesis and alkaloids
- Neurological Disease Mechanisms and Treatments
- Medicinal Plants and Neuroprotection
- Neuroinflammation and Neurodegeneration Mechanisms
- Natural Antidiabetic Agents Studies
- Neurological Disorders and Treatments
- Schizophrenia research and treatment
- Neuropeptides and Animal Physiology
- Berberine and alkaloids research
- Cholinesterase and Neurodegenerative Diseases
- Liver Disease Diagnosis and Treatment
- Diabetes and associated disorders
- Neurotransmitter Receptor Influence on Behavior
- Nitric Oxide and Endothelin Effects
- Phytochemicals and Antioxidant Activities
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Parkinson's Disease Mechanisms and Treatments
- Trace Elements in Health
- Pharmacological Effects of Natural Compounds
- Biochemical effects in animals
- Antioxidant Activity and Oxidative Stress
- Alzheimer's disease research and treatments
- Plant Toxicity and Pharmacological Properties
Universiti Sains Malaysia
2016-2025
Hospital Universiti Sains Malaysia
2024
Medical University of the Americas
2023
Friedrich-Alexander-Universität Erlangen-Nürnberg
2022
National Neuroscience Institute
2020-2021
Bangladesh University of Health Sciences
2014
Bangladesh Institute of Research and Rehabilitation for Diabetes Endocrine and Metabolic Disorders
2000-2014
Jatiya Kabi Kazi Nazrul Islam University
2013
Tarbiat Modares University
2013
Queen Mary University of London
2004
Gynura procumbens (Lour.) Merr (family Compositae) is cultivated in Southeast Asia, especially Indonesia, Malaysia and Thailand, for medicinal purposes. This study evaluated the vivo hypoglycemic properties of water extract G. following 14 days treatment vitro RIN-5F cells. Glucose absorption from intestines its glucose uptake abdominal skeletal muscle were assessed. The antidiabetic effect leaves was investigated streptozotocin-induced diabetic rats. intraperitoneal tolerance test (IPGTT)...
Abstract Mitragynine is the major psychoactive alkaloid of plant kratom/ketum. Kratom widely used in S outheast A sia as a recreational drug, and increasingly appears pure compound or component ‘herbal high’ preparations W estern world. While mitragynine/kratom may have analgesic, muscle relaxant anti‐inflammatory effects, its addictive properties effects on cognitive performance are unknown. We isolated mitragynine from performed thorough investigation behavioural rats mice. Here we...
Opiate addiction is a major health problem in many countries. A crucial component of the medical treatment management highly aversive opiate withdrawal signs, which may otherwise lead to resumption drug taking. In medication-assisted (MAT), methadone and buprenorphine have been implemented as substitution drugs. Despite MAT effectiveness, there are still limitations side effects using buprenorphine. Thus, other alternative therapies with less effects, overdosing, co-morbidities desired. One...
We investigated the effects of zerumbone (1 and 10 mg/kg) against hyperactivity, anxiety memory impairment in scopolamine-induced dementia Sprague-Dawley rats.Open field tests, elevated plus maze Morris water were performed to assess general locomotor activity, anxiety-like behaviours learning processes respectively rats pretreated with scopolamine.Scopolamine-treated showed high total stereotype, distance travelled open arena, reduced number entries arms, decreased percentage time spent...
Kratom or Mitragyna speciosa (Korth.) is a medicinal plant of Southeast Asia. As result its opioid-like effects, it remains unknown whether consumption kratom tea associated with impaired cognitive function. We assessed the function 70 regular users and 25 control participants using Cambridge Neuropsychological Test Automated Battery. Participants performed six neuropsychological tasks that motor, learning memory, attention executive Relative to participants, higher (>3 glasses daily...
Background and Purpose Kratom is a preparation from Mitragyna speciosa , which used as natural drug for many purposes around the world. However, an overdose of may cause addiction‐like problems including aversive withdrawal states resulting in cognitive impairments via unknown mechanisms. Its main psychoactive alkaloid mitragynine, showing opioid‐like properties. Experimental Approach Here, we analysed neuropharmacological effects mitragynine compared with morphine rats searched...
Background: Mitragynine is the major alkaloid of Mitragyna speciosa (Korth.) or Kratom, a psychoactive plant widely abused in Southeast Asia. While addictive effects substance are emerging, adverse cognitive this drug and neuropharmacological actions insufficiently understood. Aims: In present study, we investigated mitragynine on spatial learning synaptic transmission CA1 region hippocampus. Methods: Male Sprague Dawley rats received daily (for 12 days) training sessions Morris water maze,...
Abstract Alzheimer’s disease (AD) is the second most occurring neurological disorder after stroke and associated with cerebral hypoperfusion, possibly contributing to cognitive impairment. In present study, neuroprotective anti-AD effects of embelin were evaluated in chronic hypoperfusion (CCH) rat model using permanent bilateral common carotid artery occlusion (BCCAO) method. Rats administered at doses 0.3, 0.6 or 1.2 mg/kg (i.p) on day 14 post-surgery tested Morris water maze (MWM)...
Point mutations in the α-synuclein coding gene may lead to development of Parkinson's disease (PD). PD is often accompanied by other psychiatric conditions, such as anxiety, depression, and drug use disorders, which typically emerge adulthood. Some these point mutations, SNCA A30T, have been linked behavioral effects that are not commonly associated with PD, especially regarding alcohol consumption patterns. In this study, we investigated whether familial mutation A53T changes behavior...