A5070921284- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Legal and Labor Studies
- Schizophrenia research and treatment
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Law, AI, and Intellectual Property
- Neurological disorders and treatments
- Corporate Governance and Law
- Corporate Insolvency and Governance
- Treatment of Major Depression
- Chemical synthesis and alkaloids
- Neuroinflammation and Neurodegeneration Mechanisms
- Gut microbiota and health
- Bipolar Disorder and Treatment
- Mental Health Research Topics
- IoT Networks and Protocols
- Circadian rhythm and melatonin
- Ion Transport and Channel Regulation
- Alkaloids: synthesis and pharmacology
- Electrolyte and hormonal disorders
- Bioethics and Human Rights Issues
- Neuroendocrine regulation and behavior
- Olfactory and Sensory Function Studies
Medical University of South Carolina
2017-2022
Charité - Universitätsmedizin Berlin
2021-2022
University of Cincinnati
2022
Friedrich-Alexander-Universität Erlangen-Nürnberg
2011-2021
University of North Carolina at Chapel Hill
2020
Columbia University
2020
The University of Tokyo
2018
Osaka University
2018
Kyoto University
2018
Nagoya University
2018
Conversion of soluble α-synuclein into insoluble and fibrillar inclusions is a hallmark Parkinson's disease other synucleinopathies. Accumulating evidence points towards relationship between its generation at nerve terminals structural synaptic pathology. Little known about the pathogenic impact conversion deposition nigrostriatal dopaminergic synapses in transgenic mice, mainly owing to expression limitations construct. Here, we explore whether both rat as model bacterial artificial...
Abstract Mitragynine is the major psychoactive alkaloid of plant kratom/ketum. Kratom widely used in S outheast A sia as a recreational drug, and increasingly appears pure compound or component ‘herbal high’ preparations W estern world. While mitragynine/kratom may have analgesic, muscle relaxant anti‐inflammatory effects, its addictive properties effects on cognitive performance are unknown. We isolated mitragynine from performed thorough investigation behavioural rats mice. Here we...
Alcohol is a widely consumed drug that can lead to addiction and severe brain damage. However, alcohol also used as self-medication for psychiatric problems, such depression, frequently resulting in depression-alcoholism comorbidity. Here, we identify the first molecular mechanism use with goal self-medicate ameliorate behavioral symptoms of genetically induced innate depression. An over-expression acid sphingomyelinase (ASM), was observed depressed patients, enhanced consumption mouse model...
Abstract Antipsychotic drugs are effective interventions in schizophrenia. However, the efficacy of these agents often decreases over time, which leads to treatment failure and symptom recurrence. We report that antipsychotic rat models declines concert with extracellular striatal dopamine levels rather than insufficient D2 receptor occupancy. was associated a suppression transporter activity, reversed during failure. coincided reduced neuron firing, not observed efficacy. Synaptic field...
Antipsychotic drugs are the clinical standard for treatment of schizophrenia. Although these work initially, many compliant patients relapse due to failure. The known biomarkers can not sufficiently explain antipsychotic We, therefore, enquired how dynamic responses neurotransmitters, dopamine and serotonin, change in relation action Rats received either short-term (2–6 d) or long-term (12–14 with haloperidol, which resembled human D2 receptor occupancy, using osmotic mini-pumps. Dopamine...
In many societies, the majority of adults regularly consume alcohol. However, only a small proportion develops alcohol addiction. Individuals at risk often show high sensation-seeking/low-anxiety behavioural phenotype. Here we asked which role EF hand domain containing 2 (EFhd2; Swiprosin-1) plays in control addiction-associated behaviours. EFhd2 knockout (KO) mice drink more than controls and spontaneously escalate their consumption. This coincided with sensation-seeking low-anxiety A...
GABAergic projections from the nucleus accumbens core to dorsolateral ventral pallidum are necessary for drug-conditioned cues initiate relapse-like drug seeking. Astrocytes in situated perisynaptically and regulate GABA transmission through expression of uptake transporters, but whether they involved regulating seeking is unknown. To determine contribution pallidal astrocytes heroin seeking, we labeled male female rats with a membrane-bound fluorescent tag used confocal microscopy quantify...
Antipsychotic-induced dopamine supersensitivity, or behavioral is a problematic consequence of long-term antipsychotic treatment characterized by the emergence motor abnormalities, refractory symptoms, and rebound psychosis. The underlying mechanisms are unclear no approaches exist to prevent reverse these unwanted effects treatment. Here we demonstrate that supersensitivity stems from long-lasting pre, post perisynaptic plasticity, including insertion Ca2+-permeable AMPA receptors loss D2...
Little is known about chronic cannabis smoking-associated oral microbiome and its effects on central nervous system (CNS) functions.