A5053096586- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Sulfur Compounds in Biology
- Stress Responses and Cortisol
- Skin Protection and Aging
- Olfactory and Sensory Function Studies
- Neurotransmitter Receptor Influence on Behavior
- Biochemical effects in animals
- Antioxidant Activity and Oxidative Stress
- Receptor Mechanisms and Signaling
- Adipose Tissue and Metabolism
- Amino Acid Enzymes and Metabolism
- Neurological Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Molecular Sensors and Ion Detection
- Carcinogens and Genotoxicity Assessment
- Diet and metabolism studies
- Anesthesia and Neurotoxicity Research
- Pharmacological Receptor Mechanisms and Effects
- Cholinesterase and Neurodegenerative Diseases
- Circadian rhythm and melatonin
- Retinoids in leukemia and cellular processes
- Cannabis and Cannabinoid Research
- Mitochondrial Function and Pathology
Jagiellonian University
2016-2025
University at Buffalo, State University of New York
2022
Karolinska Institutet
2016-2017
Alcohol is a widely consumed drug that can lead to addiction and severe brain damage. However, alcohol also used as self-medication for psychiatric problems, such depression, frequently resulting in depression-alcoholism comorbidity. Here, we identify the first molecular mechanism use with goal self-medicate ameliorate behavioral symptoms of genetically induced innate depression. An over-expression acid sphingomyelinase (ASM), was observed depressed patients, enhanced consumption mouse model...
The endocannabinoid (eCB) system has recently been implicated in both the pathogenesis of depression and action antidepressants. Here, we investigated effect acutely or chronically administering antidepressants [imipramine (IMI) (15 mg/kg), escitalopram (ESC) (10 tianeptine mg/kg)] on levels eCBs [anandamide (AEA) 2-arachidonoylglycerol (2-AG)] N-acylethanolamines (NAEs) [palmitoylethanolamide (PEA) oleoylethanolamide (OEA)] various rat brain regions. We also examined ability acute chronic...
Studies on serotonin-selective reuptake inhibitors have established that disturbances in the ascending 5-HT neuron systems and their receptor subtypes collateral networks to forebrain contribute etiology of major depression are targets for treatment. The therapeutic action is proven effectiveness, but mechanisms underlying effect still unclear. There many involved; some need be blocked (e.g., 5-HT2A, 5-HT3, 5-HT7), whereas others activated postjunctional 5-HT1A 5-HT4). These state-of-the-art...
One of the major players in pathophysiology cerebral ischemia is disrupted homeostasis glutamatergic neurotransmission, resulting elevated extracellular glutamate (Glu) concentrations and excitotoxicity-related cell death. In brain, Glu are regulated by transporters, including transporter-1 (GLT-1) cystine/Glu antiporter (system xc-). Modulation these transporters administration ceftriaxone (CEF, 200 mg/kg, i.p.) or N-acetylcysteine (NAC, 150 for 5 days before focal may induce brain...
The bidirectional communication between neurons and microglia is fundamental for the homeostasis biological function of central nervous system. Maternal immune activation (MIA) considered to be one factors affecting these interactions. Accordingly, MIA has been suggested involved in several neuropsychiatric diseases, including schizophrenia. crucial regulatory systems neuron-microglia crosstalk are CX3CL1-CX3CR1 CD200-CD200R axes.
Ischemic stroke is the third leading cause of death in world, which accounts for almost 12% total deaths worldwide. Despite decades research, available and effective pharmacotherapy limited. Some evidence underlines beneficial properties hydrogen sulfide (H2S) donors, such as NaSH, an animal model brain ischemia vitro research; however, these data are ambiguous. This study was undertaken to verify neuroprotective activity AP39, a slow-releasing mitochondria-targeted H2S delivery molecule. We...
Glutamate (Glu) plays a key role in excitotoxicity-related injury cerebral ischemia. In the brain, Glu homeostasis depends on transporters, including excitatory amino acid transporters and cysteine/Glu antiporter (xc-). We hypothesized that drugs acting such as ceftriaxone (CEF, 200 mg/kg, i.p.) N-acetylcysteine (NAC, 150 i.p.), administered repeatedly for 5 days before focal ischemia rats induced by 90-min middle artery occlusion (MCAO), may induce brain tolerance to compared effects of...
Brain ischemia is one of the leading causes death and long-term disability in world. Interruption blood supply to brain a direct stimulus for many pathological events. The massive vesicular release glutamate (Glu) after onset induces excitotoxicity, which potent stress on neurons. Loading presynaptic vesicles with Glu first step glutamatergic neurotransmission. Vesicular transporters 1, 2, 3 (VGLUT1, 3) are main players involved filling Glu. VGLUT1 VGLUT2 expressed mainly Therefore,...
Benzophenone-3 is the most commonly used UV filter. It well absorbed through skin and gastrointestinal tract. Its best-known side effect impact on function of sex hormones. Little known about influence BP-3 brain. The aim this study was to show whether crosses blood-brain barrier (BBB), determine it induces nerve cell damage in susceptible brain structures, identify mechanism its action central nervous system. administered dermally during prenatal period adulthood rats. short-term spatial...
Abstract Benzophenone-3 (BP-3), the most widely used UV chemical filter, is absorbed well through skin and gastrointestinal tract can affect some body functions, including survival of nerve cells. Previously, we showed that BP-3 evoked a neurotoxic effect in male rats, but since effects this compound are known to depend on gender, aim present study was show concentration potential action female rat brain. administered dermally rats during pregnancy, then 7th 8th weeks age their offspring....
In human addicts and in animal models, chronic cocaine use leads to numerous alterations glutamatergic transmission, including its receptors. The present study focused on metabotropic receptors type 5 (mGluR5) N-methyl-D-aspartate receptor subunits (NMDAR: GluN1, GluN2A, GluN2B) proteins during self-administration after 10-day of extinction training rats. To discriminate the contingent from non-contingent delivery, we employed "yoked"-triad control procedure. Protein expression rat...
A proper reference gene (RG) is required to reliably measure mRNA levels in biological samples via quantitative reverse transcription PCR (RT-qPCR). Various experimental paradigms require specific and stable RGs. In studies using rodent models of brain ischaemia, a variety genes, such as β-actin (Actb), hypoxanthine phosphoribosyltransferase 1 (Hprt1), peptidyl-propyl isomerase (Ppia) glyceraldehyde-3-phosphate dehydrogenase (Gapdh), are used However, most these genes have not been validated...
Ethylene glycol ethers (EGEs) are components of many industrial and household products. Their hemolytic gonadotoxic effects relatively well known while their potential adverse on the central nervous system have not yet been clearly demonstrated. The aim present study was to examine 4-week administration 2-buthoxyethanol (BE), 2-phenoxyethanol (PHE) 2-ethoxyethanol (EE) total antioxidant capacity, activity some enzymes, such as superoxide dismutase (SOD), catalase, glutathione peroxidase...