A5053149454- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Nicotinic Acetylcholine Receptors Study
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Cannabis and Cannabinoid Research
- Memory and Neural Mechanisms
- Pharmacological Receptor Mechanisms and Effects
- Stress Responses and Cortisol
- Forensic Toxicology and Drug Analysis
- Pharmacological Effects and Assays
- Neurogenesis and neuroplasticity mechanisms
- Adipose Tissue and Metabolism
- Adenosine and Purinergic Signaling
- Synthesis and Biological Evaluation
- Sleep and Wakefulness Research
- Psychedelics and Drug Studies
- melanin and skin pigmentation
- Chemical synthesis and alkaloids
- Insect and Pesticide Research
- Nerve injury and regeneration
- Treatment of Major Depression
- Neuropeptides and Animal Physiology
- Regulation of Appetite and Obesity
Maj Institute of Pharmacology
2014-2024
Polish Academy of Sciences
2014-2024
Max Delbrück Center
2015-2023
Abstract We investigated the changes in dopamine ( DA ), glutamate and γ‐aminobutyric acid GABA ) during cocaine self‐administration rats implanted with guide cannulae into nucleus accumbens ventral pallidum. After stabilized self‐administration, separate groups of underwent extinction (10 days) procedure which infusion was replaced by saline injections. With using a ‘yoked’ procedure, effects or its withdrawal on level neurotransmitters were evaluated dual‐probe microdialysis. Repeated...
A growing body of evidence implicates the endocannabinoid (eCB) system in pathophysiology depression. The aim this study was to investigate influence changes eCB system, such as levels neuromodulators, synthesizing and degrading enzymes, cannabinoid (CB) receptors, different brain structures animal models depression using behavioral biochemical analyses. Both used, i.e., bulbectomized (OBX) Wistar Kyoto (WKY) rats, were characterized at level by increased immobility time. In OBX anandamide...
Abstract Male Wistar rats were used to verify the hypothesis that serotonin (5‐HT) 2A or 5‐HT 2C receptors may control locomotor effects evoked by nicotine (0.4mg/kg). The receptor antagonist (M100,907), agonist (DOI), (SB 242,084), and agonists (Ro 60‐0175 WAY 163,909) used. M100,907 (0.5–2mg/kg) did not alter, while DOI (1 mg/kg) enhanced nicotine‐induced hyperlocomotion. effect of was antagonized mg/kg). SB 242,084 (0.25–1 augmented, Ro 3 163,909 (1.5 decreased overall acute nicotine;...
Abstract The objective of this study was to evaluate the efficacy varenicline, a novel partial agonist at α4β2 and full α7 nicotinic acetylcholine receptor (nAChR) subtypes, in blocking locomotor effects acute or repeated treatments with nicotine (0.4 mg/kg, s.c.) rats. Varenicline (0.3–3 by itself enhanced basal activity naive rats while it had an inhibitory effect on nicotine‐induced hyperlocomotion. mg/kg) did not change nicotine‐evoked conditioned locomotion, but when administered...
Abstract We verified the hypothesis that serotonin (5‐HT) 2 receptors control locomotor effects of nicotine (0.4 mg kg −1 ) in rats by using 5‐HT 2A receptor antagonist M100907, preferential agonist DOI, 2C SB 242084, and agonists Ro 60‐0175 WAY 163909. Repeated pairings a test environment with for 5 days, on Day 10 significantly augmented activity following administration. Of investigated ligands, M100907 (2 or DOI (1 administered during first days combination attenuated enhanced,...
We have previously demonstrated that nicotine withdrawal produces depression-like behavior and serotonin (5-HT)2A/2C receptor ligands modulate mood-like state. In the present study we aimed to identify mechanisms (changes in radioligand binding, transcription or RNA-editing) related such a behavioral outcome. Rats received vehicle (0.4 mg/kg, s.c.) for 5 days home cages. Brain 5-HT2A/2C receptors were analyzed on day 3 of withdrawal. Nicotine increased [(3)H]ketanserin binding 5-HT2A ventral...