A5082217118- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Tryptophan and brain disorders
- Neurotransmitter Receptor Influence on Behavior
- Pharmacological Receptor Mechanisms and Effects
- Stress Responses and Cortisol
- Neuropeptides and Animal Physiology
- Natural Compound Pharmacology Studies
- Treatment of Major Depression
- Neuroinflammation and Neurodegeneration Mechanisms
- Synthesis and biological activity
- Cardiac electrophysiology and arrhythmias
- Eicosanoids and Hypertension Pharmacology
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Biological Evaluation
- Memory and Neural Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Diet and metabolism studies
- Alkaloids: synthesis and pharmacology
- Nerve injury and regeneration
- Trace Elements in Health
- Olfactory and Sensory Function Studies
- Medicinal Plants and Neuroprotection
- Cardiac Ischemia and Reperfusion
- Biochemical effects in animals
Jagiellonian University
2015-2024
University of Lisbon
2023
Weatherford College
2023
University of Strathclyde
2020-2021
Instytut Farmaceutyczny
2013
Farmak (Czechia)
2013
A series of new derivatives N-(2-methoxyphenyl)piperazine have been synthesized for their affinity toward serotonergic receptors and potential antidepressant-like activity. They evaluated 5-HT1A , 5-HT6 5-HT7 as well in vivo the tail suspension, locomotor activity, motor co-ordination tests. All tested compounds proved very good affinities receptors. The most promising compound was 1-[(2-chloro-6-methylphenoxy)ethoxyethyl]-4-(2-methoxyphenyl)piperazine hydrochloride, exhibiting Ki <1 nm...
The aim of this study was to further characterize pharmacological properties two phenylpiperazine derivatives: 1-{2-[2-(2,6-dimethlphenoxy)ethoxy]ethyl}-4-(2-methoxyphenyl)piperazynine hydrochloride (HBK-14) and 2-[2-(2-chloro-6-methylphenoxy)ethoxy]ethyl-4-(2- methoxyphenyl)piperazynine dihydrochloride (HBK-15) in radioligand binding functional vitro assays as well vivo models. Antidepressant-like were investigated the forced swim test (FST) mice rats. Anxiolytic-like activity evaluated...
The search for drugs with anorectic activity, acting within the adrenergic system has attracted interest of researchers. Partial α2-adrenoceptor agonists might offer potential effective and safe treatment obesity. We compared effectiveness safety ligands in reducing body mass. also analyzed if antagonist partial α2-adrenoceptor––yohimbine guanfacine––act similarly, determined which course action is connected activity. tested intrinsic activity effect on lipolysis these compounds cell...
Studies suggest that the blockade of 5-HT1A, 5-HT7, and 5-HT3 receptor may increase speed antidepressant response. 1-[(2,6-Dimethylphenoxy)ethoxyethyl]-4-(2-methoxyphenyl)piperazine hydrochloride (HBK-14) 1-[(2-chloro-6-methylphenoxy)ethoxyethyl]-4-(2-methoxyphenyl)piperazine (HBK-15), dual 5-HT1A 5-HT7 antagonists, showed significant antidepressant- anxiolytic-like properties in our previous tests rodents. In this study, we aimed to investigate their potential using mouse model...
The most troublesome aspects of behavioral and psychological symptoms dementia (BPSD) are nowadays addressed by antidepressant, anxiolytic, antipsychotic drugs, often administered off-label. Considering their modest effectiveness in patients, the increased risk adverse events cognitive decline, there is an unmet need for well-tolerated effective therapy BPSD. We designed synthesized multifunctional ligands characterized vitro as high-affinity partial agonists D2R, antagonists 5-HT6R,...
Novel 1-(1-benzoylpiperidin-4-yl)methanamine derivatives were designed as "biased agonists" of serotonin 5-HT1A receptors. The compounds tested in signal transduction assays (ERK1/2 phosphorylation, cAMP inhibition, Ca2+ mobilization, and β-arrestin recruitment) which identified ERK1/2 phosphorylation-preferring aryloxyethyl derivatives. novel series showed high receptor affinity, >1000-fold selectivity versus noradrenergic α1, dopamine D2, 5-HT2A, histamine H1, muscarinic M1 receptors,...
<b>Objectives:</b> Xanthones are flavonoids with numerous activities, including antioxidant, antidepressant., or anxiolytic-like. Therefore, the aim of our study was to determine antidepressant- and anxiolytic-like properties four xanthone derivatives (3-chloro-5-[(4-methylpiperazin-1-yl)methyl]-9H-xanthen-9-one dihydrochloride [HBK-5], 6-methoxy-2-[(4-methylpiperazin-1-yl) methyl]-9H-xanthen-9-one dihydrochloride, 2-[(4-benzylpiperazin-1-yl) methyl]-6-methoxy-9H-xanthen-9-one...
The use of atypical antipsychotic drugs like olanzapine is associated with side effects such as sedation and depression-like symptoms, especially during the initial period use. It believed that occurrence these undesirable effectsis mainly result histamine H1receptors blockade by olanzapine. In addition, increases level triglycerides in blood, which correlates growing obesity. aim this study was to investigate influence pitolisant – H3 antagonist - on subchronic olanzapine-induced...
Studies proved that among all α1-adrenoceptors, cardiac myocytes functionally express only α1A- and α1B-subtype. Scientists indicated α1A-subtype blockade might be beneficial in restoring normal heart rhythm. Therefore, we aimed to determine the role of α1-adrenoceptors subtypes (i.e. α1A α1B) antiarrhythmic effect six structurally similar derivatives 2-methoxyphenylpiperazine. We compared activity studied compounds with carvedilol, which is β1- blocker antioxidant properties. To evaluate...