A5032257741- Sulfur Compounds in Biology
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Biochemical effects in animals
- Stress Responses and Cortisol
- Olfactory and Sensory Function Studies
- Adipose Tissue and Metabolism
- Skin Protection and Aging
- Mitochondrial Function and Pathology
- Tryptophan and brain disorders
- Retinoids in leukemia and cellular processes
- Neurological Disease Mechanisms and Treatments
- Cardiovascular Disease and Adiposity
- Vitamin C and Antioxidants Research
- Neurological Disorders and Treatments
- Photoreceptor and optogenetics research
- Cholinesterase and Neurodegenerative Diseases
- Effects and risks of endocrine disrupting chemicals
- Heme Oxygenase-1 and Carbon Monoxide
- Nanocluster Synthesis and Applications
- Treatment of Major Depression
- Pancreatic function and diabetes
- Autophagy in Disease and Therapy
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Anesthesia and Neurotoxicity Research
Jagiellonian University
2020-2025
The bidirectional communication between neurons and microglia is fundamental for the homeostasis biological function of central nervous system. Maternal immune activation (MIA) considered to be one factors affecting these interactions. Accordingly, MIA has been suggested involved in several neuropsychiatric diseases, including schizophrenia. crucial regulatory systems neuron-microglia crosstalk are CX3CL1-CX3CR1 CD200-CD200R axes.
Ischemic stroke is the third leading cause of death in world, which accounts for almost 12% total deaths worldwide. Despite decades research, available and effective pharmacotherapy limited. Some evidence underlines beneficial properties hydrogen sulfide (H2S) donors, such as NaSH, an animal model brain ischemia vitro research; however, these data are ambiguous. This study was undertaken to verify neuroprotective activity AP39, a slow-releasing mitochondria-targeted H2S delivery molecule. We...
Implant-associated infections are a frequent complication of surgeries involving biomaterial implants. Staphylococcus and Enterococcus species the leading causes linked to bone-anchored joint To address this challenge, developing antibacterial coatings prevent bacterial attachment biofilm formation on biomaterials is critical. This study aimed evaluate antibiofilm properties two coatings: titanium nitride (TiN) with silver nanoparticles (TiN/Ag). Antibacterial activity was tested against...
Among serotonin receptors, the 5-HT6 subtype is an important protein target and its ligands may play a key role in innovative treatment of cognitive disorders. This study aimed to extend body preclinical research on two naphthyl-derived methylpiperazine-1,3,5-triazine analogues with thioether (WA-22) or Se-ether (PPK-32) linkers, newly described compounds having high affinity selectivity for receptors drug-like parameters vitro. Thus, crystallography-supported deeper insight into their...
Brain ischemia is one of the leading causes death and long-term disability in world. Interruption blood supply to brain a direct stimulus for many pathological events. The massive vesicular release glutamate (Glu) after onset induces excitotoxicity, which potent stress on neurons. Loading presynaptic vesicles with Glu first step glutamatergic neurotransmission. Vesicular transporters 1, 2, 3 (VGLUT1, 3) are main players involved filling Glu. VGLUT1 VGLUT2 expressed mainly Therefore,...
Benzophenone-3 is the most commonly used UV filter. It well absorbed through skin and gastrointestinal tract. Its best-known side effect impact on function of sex hormones. Little known about influence BP-3 brain. The aim this study was to show whether crosses blood-brain barrier (BBB), determine it induces nerve cell damage in susceptible brain structures, identify mechanism its action central nervous system. administered dermally during prenatal period adulthood rats. short-term spatial...
Abstract Benzophenone-3 (BP-3), the most widely used UV chemical filter, is absorbed well through skin and gastrointestinal tract can affect some body functions, including survival of nerve cells. Previously, we showed that BP-3 evoked a neurotoxic effect in male rats, but since effects this compound are known to depend on gender, aim present study was show concentration potential action female rat brain. administered dermally rats during pregnancy, then 7th 8th weeks age their offspring....
A proper reference gene (RG) is required to reliably measure mRNA levels in biological samples via quantitative reverse transcription PCR (RT-qPCR). Various experimental paradigms require specific and stable RGs. In studies using rodent models of brain ischaemia, a variety genes, such as β-actin (Actb), hypoxanthine phosphoribosyltransferase 1 (Hprt1), peptidyl-propyl isomerase (Ppia) glyceraldehyde-3-phosphate dehydrogenase (Gapdh), are used However, most these genes have not been validated...
The present study explores the synthesis and bio-safety evaluation of gadolinium-doped carbon quantum dots (GCQDs) as a potential dual-contrast agent for diagnostic imaging. GCQDs exhibit both fluorescent magnetic properties, making them suitable UV-Vis resonance imaging (MRI). was achieved via hydrothermal treatment, incorporating gadolinium into dot matrix. properties were analyzed, showing significantly enhanced values compared to gadobutrol, common MRI contrast agent. However,...
Brain ischemia is one of the leading causes death and long-term disability worldwide. Cessation blood supply to brain directly stimulates many pathological events, including glutamate overload neuroinflammation. Glial cell activation occurs shortly after onset, resulting in release proinflammatory cytokines exacerbation detrimental effects Proinflammatory signals influence infiltration a wide range immune cells, neutrophils, T cells monocytes/macrophages. In this study, we aimed verify...
Abstract Aims Atherosclerosis is a leading cause of morbidity and mortality in the Western countries. A growing body evidence points to role mitochondrial dysfunction pathogenesis atherosclerosis. Recently, it has been shown that hydrogen sulfide (H 2 S) can complement bioenergetic Krebs cycle improved function. However, controlled, direct delivery H S mitochondria was not investigated as therapeutic strategy Therefore, aim our study comprehensively evaluate influence prolonged treatment...
<title>Abstract</title> Glutamate (Glu) is a major excitatory neurotransmitter in the brain, essential for synaptic plasticity, neuronal activity, and memory formation. However, its dysregulation leads to excitotoxicity, implicated neurodegenerative diseases brain ischemia. Vesicular glutamate transporters (VGLUTs) regulate Glu loading into vesicles, crucial maintaining optimal extracellular levels. This study investigates neuroprotective effects of VGLUT1 inhibition HT22 cells...
Abstract Glutamate (Glu) is a major excitatory neurotransmitter in the brain, essential for synaptic plasticity, neuronal activity, and memory formation. However, its dysregulation leads to excitotoxicity, implicated neurodegenerative diseases brain ischemia. Vesicular glutamate transporters (VGLUTs) regulate Glu loading into vesicles, crucial maintaining optimal extracellular levels. This study investigates neuroprotective effects of VGLUT1 inhibition HT22 cells overexpressing under oxygen...
Selective enhancement of synaptic GABA signaling mediated by GABA-A receptors has been previously reported to promote functional recovery after ischemic stroke, while tonic detrimental. To identify agents that enhance signaling, we synthesized ligands based on three chemotypes with affinity values pKi= 6.44–8.32. Representative compounds showed a preference in responses toward type receptors, compared the extrasynaptic ones. In cellular ischemia model (OGD), selected potential improve...
Background and Purpose. Brain ischemia is one of the leading causes death long-term disability worldwide. Cessation blood supply to brain directly stimulates many pathological events, including glutamate overload neuroinflammation. Glial cell activation occurs shortly after onset, resulting in release proinflammatory cytokines exacerbation detrimental effects Proinflammatory signals influence infiltration a wide range immune cells, neutrophils, T cells monocytes/macrophages. In this study,...
Abstract Ischemic stroke represents a significant global health challenge and ranks as the third leading cause of mortality worldwide, contributing to approximately 12% total deaths. Despite extensive research endeavors, effective pharmacotherapy options for treatment ischemic remain limited. The existing body evidence concerning effects H 2 S donors in displays conflicting ambiguous results. In this study we assess neuroprotective attributes AP39, mitochondria-targeted delivery molecule...
Abstract Brain ischemia is one of the leading causes death and long-term disability in world. Interruption blood supply to brain a direct stimulus for many pathological events. The massive vesicular release glutamate (Glu) after onset induces excitotoxicity, which potent stress on neurons. Loading presynaptic vesicles with Glu first step glutamatergic neurotransmission. Vesicular transporters 1, 2, 3 (VGLUT1, 2 3) are main players involved filling Glu. VGLUT1 VGLUT2 expressed mainly...