A5048700726- Hepatitis B Virus Studies
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Cancer-related gene regulation
- Cannabis and Cannabinoid Research
- Soil Carbon and Nitrogen Dynamics
- Pharmaceutical and Antibiotic Environmental Impacts
- Circular RNAs in diseases
- Enzyme Production and Characterization
- Cancer, Hypoxia, and Metabolism
- Water Treatment and Disinfection
- Cancer Mechanisms and Therapy
- Microbial Metabolites in Food Biotechnology
- Cancer Cells and Metastasis
- Advanced oxidation water treatment
- Gut microbiota and health
- Tryptophan and brain disorders
- RNA Research and Splicing
- Chemotherapy-induced cardiotoxicity and mitigation
- Cervical Cancer and HPV Research
Heilongjiang Academy of Sciences
2023-2025
Guiyang Medical University
2025
Affiliated Hospital of Guizhou Medical University
2025
Henan University of Science and Technology
2023-2025
Medical University of South Carolina
2020-2024
Fujian Medical University
2020-2024
Beijing University of Technology
2023-2024
Wuhan University
2022-2024
Renmin Hospital of Wuhan University
2022-2024
Xinjiang University
2024
HOX transcript antisense RNA (HOTAIR), which is expressed from the homebox C gene (HOXC) locus, capable of reprogramming chromatin organisation and promoting cancer cell metastasis can simultaneously bind polycomb repressive complex 2, enhances H3K27 trimethylation, LSD1-CoREST-REST complex, critical for H3K4 demethylation. Clinically, overexpression HOTAIR a powerful predictor tumour progression overall survival in patients with diverse cancers. The relationship between oesophageal squamous...
Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer in adults. Previous studies our laboratory found that long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) was upregulated HCC cells, which could affect metastasis and invasion of HCC. However, underlying mechanism remains unknown. Herein, we studied interaction between MALAT1 miR-140 on regulation angiogenesis immunosuppressive properties. We revealed expression VEGF-A significantly...
Increasing evidence supports the significance of long non-coding RNA in cancer development. Several recent studies suggest oncogenic activity metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) hepatocellular carcinoma. In this study, we explored molecular mechanisms by which MALAT1 modulates carcinoma biological behaviors. We found that microRNA-204 was significantly downregulated sh-MALAT1 HepG2 cell and 15 tissues quantitative real-time polymerase chain reaction analysis....
Previous studies have demonstrated the protective signaling of hypoxia-inducible factor (HIF)-1 α against ischemia-reperfusion (I/R) injury in heart. In present study, we provide further evidence for a cardioprotective mechanism by HIF-1α I/R exerted via mitochondrial protein frataxin, which regulates Fe-S cluster formation. Disruption frataxin has been found to induce iron overload and subsequent ROS production. We observed that expression was elevated mice hearts subjected injury, this...
miR-210 is upregulated in a HIF-1α-dependent way several types of cancers. In addition, promotes cancer proliferation, via its anti-apoptotic effects. It blind to the regulation under hypoxia conditions for ovarian cells and effect on growth. present study, we determined expression epithelial specimens, cell lines conditions, detail overexpression tumor possible mechanisms growth by regulation. was shown that upregulated, response specimens as well lines, with an association HIF-1α...
In living organisms, daily light/dark cycles profoundly affect cellular processes. plants, optimal growth and development, adaptation to light-dark cycles, require starch synthesis turnover. However, the underlying molecular mechanisms coordinating metabolism remain poorly understood. To explore roles of Arabidopsis thaliana light signal transduction proteins FAR-RED ELONGATED HYPOCOTYLS3 (FHY3) FAR-RED-IMPAIRED RESPONSE1 (FAR1) in metabolism, contents water-soluble polysaccharides,...
In order to explore the molecular mechanisms of Populus simonii × P. nigra response stress and screen for genes conferring resistance Alternaria alternata , we carried out measurements physiological biochemical indices transcriptomic sequence analysis leaves inoculated with A. . The results showed that variation trends multiple hormone contents enzyme activities were broadly similar at different time points, H 2 O SA, JA, PPO, SOD, PAL POD showing a trend increasing then decrease after...
Activating adult neural stem cells (NSCs) located within the spinal cord niche is considered a promising therapeutic approach for treating injury (SCI). Cerebrospinal fluid (CSF)-contacting neurons expressing Pkd2l1 exhibit phenotypic and molecular traits similar to those of NSCs. However, mechanism responsible regulating activation Pkd2l1+ CSF-cNs still needs be discovered. This research demonstrated that have high concentration vascular endothelial growth factor receptor 3 (Vegfr3) SCI...
Auxin plays a versatile role in regulating plant growth and development. The auxin efflux carrier PIN-FORMED (PIN) proteins dictate the distribution maximum of within various tissues. Despite extensive research on OsPINs recent years, their functions abiotic stress resistance, particularly cold tolerance, remain poorly understood. Here, we investigated OsPIN5b rice (Oryza sativa L.) development, as well its contribution to tolerance using overexpression technology. Overexpression (OE)...
Hepatitis B virus X protein (HBx) is recognized as an oncogene in hepatocellular carcinoma (HCC). HBx regulates microRNA expression, including down-regulating miR-338-3p LO2 cells. Here, we investigated function HBx-mediated hepatocarcinogenesis. In 23 HBV-infected HCC clinical patient tumor and adjacent non-tumor control tissues, 17 19 tumors expressed mRNA protein, respectively. When considered a group, had lower expression than controls; however, was only significantly down-regulated...
Arctigenin is a biologically active lignan extracted from the seeds of Arctium lappa and shows anticancer activity against variety human cancers. The aim this study was to determine effects arctigenin on ovarian cancer cell proliferation survival associated molecular mechanisms. Human OVCAR3 SKOV3 cells were treated with arctigenin, apoptosis assessed. Western blot analysis used examine signal transducer activator transcription-3 (STAT3) phosphorylation survivin inducible nitric oxide...
Abstract Mesenchymal stem cells (MSCs) have potential ability to differentiate into osteocytes in response vitro specific induction. However, the molecular basis underlying this biological process remains largely unclear. In study, we identify lncRNA HOTAIRM1 as a critical regulator promote osteogenesis of MSCs. Loss significantly inhibits calcium deposition and alkaline phosphatase activity Mechanistically, find that positively modulates JNK c‐Jun, both which are widely accepted crucial...
ABSTRACT Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has progressed to a pandemic associated with substantial morbidity and mortality. WHO the United States Center for Disease Control Prevention (CDC) have issued interim clinical guidance management of patients confirmed disease (COVID-19), but there is limited data on virologic characteristics prognosis COVID-19. Methods A total 50 COVID-19 were divided into good poor recovery groups. dynamic viral shedding...
Doxorubicin (DOX) is a highly effective anti-neoplastic agent; however, its cumulative dosing schedules are clinically limited by the development of cardiotoxicity. Previous studies have attributed cause DOX-mediated cardiotoxicity to mitochondrial iron accumulation and ensuing reactive oxygen species (ROS) formation. The present study investigates role frataxin (FXN), iron-sulfur biogenesis protein, in dysfunction. Athymic mice treated with DOX (5 mg/kg, 1 dose/wk treatments, followed 2-wk...