A5033449880- Synthesis and biological activity
- Computational Drug Discovery Methods
- vaccines and immunoinformatics approaches
- Synthesis and Characterization of Heterocyclic Compounds
- Essential Oils and Antimicrobial Activity
- Nanoparticles: synthesis and applications
- Tryptophan and brain disorders
- Chemotherapy-induced cardiotoxicity and mitigation
- Enzyme Production and Characterization
- Mitochondrial Function and Pathology
- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Natural Antidiabetic Agents Studies
- Neuroscience and Neuropharmacology Research
- Probiotics and Fermented Foods
- Alzheimer's disease research and treatments
- Autism Spectrum Disorder Research
- Metal complexes synthesis and properties
- Microbial Metabolites in Food Biotechnology
- Immunotherapy and Immune Responses
- Synthesis and Biological Evaluation
- Enzyme Catalysis and Immobilization
- Genetic Neurodegenerative Diseases
- Nigella sativa pharmacological applications
- Medicinal Plants and Neuroprotection
King Saud University
2018-2025
Ministry of Health
2025
Universidade Federal do Cariri
2024
University of Lahore
2024
Armed Forces Hospital
2018-2023
Naif Arab University for Security Sciences
2022
Cardiff University
2022
Auburn University
2014-2015
Abstract A library of novel bis -Schiff base derivatives based on thiobarbituric acid has been effectively synthesized by multi-step reactions as part our ongoing pursuit anti-diabetic agents. All these were subjected to in vitro α-glucosidase inhibitory potential testing after structural confirmation modern spectroscopic techniques. Among them, compound 8 (IC 50 = 0.10 ± 0.05 µM), and 9 0.13 0.03 µM) exhibited promising activity better than the standard drug acarbose 0.27 0.04 µM)....
Recently, nanobiotechnology has attracted a lot of attention, as it is rapidly emerging field that still growing and developing efficient advanced therapeutic protocols under the umbrella nanomedicine. It can revolutionize solutions to biomedical problems by effective treatment therapeutics. However, focus research are required make these therapeutics more safer use. In this study, iron oxide nanoparticles were synthesized from Madhuca indica extract using green synthesis protocols. The...
Urease belongs to the family of amid hydrolases with two nickel atoms in their core structure. On basis literature survey, this research work is mainly focused on study bis-Schiff base derivatives benzyl phenyl ketone nucleus.Synthesis based bases search potent urease inhibitors.In current work, were synthesized through steps reaction by reacting excess hydrazine hydrate ethanol solvent first step get desired hydrazone. In last, different substituted aromatic aldehydes refluxed catalytic...
Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a critical role in cancer angiogenesis. Inhibition of VEGFR-2 activity proved effective suppression tumour propagation. Accordingly, two series new 3-methylquinoxaline derivatives have been designed and synthesised as inhibitors. The were evaluated vitro for their cytotoxic activities against MCF-7and HepG2 cell lines. In addition, the inhibitory target compounds estimated to indicate potential mechanism cytotoxicity. To great...
Novel α-amylase inhibitors play a crucial role in managing diabetes and obesity, contributing to improved public health by addressing these challenging prevalent conditions. Moreover, the synthesis of anti-oxidant agents is essential due their potential combating oxidative stress-related diseases promoting overall health.Synthesis thoisemicarbazone derivatives 2,4-dichlorophenyl acetic acid screened them for biological activities.Thiosemicarbazone (4-13) were synthesized refluxing with...
Tiagabine (Tia), a new-generation antiseizure drug that mimics the GABAergic signaling by inhibiting GABA transporter type-1, is least studied molecule in chronic epilepsy models with comorbid neurobehavioral and neuroinflammatory parameters. Therefore, current study investigated effects of Tia real-time manner on electroencephalographic (EEG) activity, behavioral manifestations mRNA expression pentylenetetrazole (PTZ)-kindled mice. Male BALB/c mice were treated tiagabine (0.5, 1 2 mg/kg)...
In this study, twenty eight novel oxadiazole derivatives (5-32) of the marketed available non-steroidal anti-inflammatory drug (NSAID), (S)-flurbiprofen (1), were synthesized via I2 mediated cyclo-addition reaction in better yields. The hydrazone-Schiff bases cyclized with iodine by using potassium hydroxide as a base DMSO solvent to obtain (5-32). Structures products confirmed HR-ESI-MS, 1H-NMR spectroscopy and CHN analysis. After structure confirmations all analogs evaluated for urease (in...
The comparative genomic analysis of Lactiplantibacillus plantarum YW11 (L. YW11) isolated from Tibetan kefir involves comparison the complete genome sequences strain with other closely related L. strains. This type can be used to identify genetic diversity among strains and explore characteristics strain. was found composed a circular single chromosome 4,597,470 bp G + C content 43.2%. A total 4,278 open reading frames (ORFs) were identified in coding density 87.8%. conducted using two...
Cancer has remained one of the leading causes death worldwide, with a lack effective treatment. The intrinsic shortcomings conventional therapeutics regarding tumor specificity and non-specific toxicity prompt us to look for alternative mitigate these limitations. In this regard, we developed multifunctional bimetallic (FeCo) bi-MIL-88B-FC MOFs modified folic acid-conjugated chitosan (FC) as drug delivery systems (DDS) targeted 5-Fluorouracil (5-FU). bi-MIL-88B nanocarriers were...
In July 2022, Langya henipavirus (LayV) was identified in febrile patients China. There is currently no approved vaccine against this virus. Therefore, research aimed to design a multi-epitope LayV using reverse vaccinology. The best epitopes were selected from LayV's fusion protein (F) and glycoprotein (G), designed these epitopes, adjuvant, appropriate linkers. physicochemical properties, antigenicity, allergenicity, toxicity, solubility of the evaluated. vaccine's secondary 3D structures...
Zero-valent iron nanoparticles (ZVI-NPs) are utilized for the indemnification of a wide range environmental pollutants. Among pollutants, heavy metal contamination is major concern due to their increasing prevalence and durability. In this study, remediation capabilities determined by green synthesis ZVI-NPs using aqueous seed extract Nigella sativa which convenient, environmentally friendly, efficient, cost-effective technique. The was as capping reducing agent generation ZVI-NPs....
Heavy metal pollution in aquatic environments threatens marine life and lowers the quality of freshwater supplies. This research aimed to quantify heavy concentration fish, avian tissue, water Mangla reservoir. Concentrations metals such as Cu, Cd, Cr, Pb were determined five vital organs six species fishes (
The problem of multidrug resistance in bacterial pathogens is significant and related to the high morbidity death rates living things due increased levels beta-lactamases. Plant-derived nanoparticles have gained a great significance field science technology combat diseases, especially multidrug-resistant bacteria. This study examines virulent genes identified pathogenic Staphylococcus species obtained from Molecular Biotechnology Bioinformatics Laboratory (MBBL), culture collection....
Oil oxidation is important in terms of taste, nutritive component quality and toxic effect the oil. In this study, oxidized sunflower oil was used along with chia seed rabbits for determination its effects on various hematological serum biochemical parameters as well liver histopathology. Three were fed (obtained by heating) at dose rate 2 ml/kg body weight mixing it green fodder. The other rabbit groups Chia 1, 3 g/kg alone to three weight. All regularly twenty-one days. For parameters,...
Abstract There is no FDA-approved drug for neurological disorders like spinocerebellar ataxia type 3. CAG repeats mutation in the ATXN3 gene, causing 3 disease. Symptoms include sleep cycle disturbance, neurophysiological abnormalities, autonomic dysfunctions, and depression. This research focuses on discovery against using phytochemicals of different plants. Three phytochemical compounds (flavonoids, diterpenoids, alkaloids) were used as potential candidates screened protein. The 3D...
Objectives: This research aimed to overcome challenges posed by cefepime excessive elimination rate and poor patient compliance developing transdermal delivery system using nano-transfersomes based chitosan gel.
This study aimed to evaluate the effects of an organic acid blend and essential oils individually in combination on growth performance, blood biochemical profile, gut health, nutrient digestibility broilers fed a higher level animal protein concentrate. Five hundred day-old Ross-308 male broiler chicks (average body weight, 39 ± 1.2 g) were randomly assigned five replicated (5 replicates/treatment; 20 birds/replica) dietary treatments (100 birds/treatment). Birds these group given different...