A5048440460- Venomous Animal Envenomation and Studies
- Marine Invertebrate Physiology and Ecology
- Neuroinflammation and Neurodegeneration Mechanisms
- Rabies epidemiology and control
- Neuroscience and Neuropharmacology Research
- Nicotinic Acetylcholine Receptors Study
- Curcumin's Biomedical Applications
- RNA Interference and Gene Delivery
- Healthcare and Venom Research
- Advanced Glycation End Products research
- Zebrafish Biomedical Research Applications
- Ion channel regulation and function
- Pharmacogenetics and Drug Metabolism
- Biochemical and Structural Characterization
- Marine Toxins and Detection Methods
- MicroRNA in disease regulation
- Mosquito-borne diseases and control
- Bioactive Compounds in Plants
- Alzheimer's disease research and treatments
- Medicinal Plants and Neuroprotection
- Computational Drug Discovery Methods
- Drug Transport and Resistance Mechanisms
- Viral Infections and Immunology Research
- Cancer, Hypoxia, and Metabolism
- Cholinesterase and Neurodegenerative Diseases
Monash University Malaysia
2015-2024
International Medical University
2022
Sunway University
2012-2020
Monash University
2009-2015
Imperial College London
1982-2005
University of Malaya
1990-2002
University of Leeds
1995
University of Maryland Medical Center
1990
University of Maryland, Baltimore
1990
University of London
1982
Epilepsy is a neuronal disorder allied with distinct neurological and behavioral alterations characterized by recurrent spontaneous epileptic seizures. Impairment of the cognitive performances such as learning memory frequently observed in patients. Anti-epileptic drugs (AEDs) are efficient to majority However, 30% this population seems be refractory drug treatment. These patients not seizure-free they show impaired functions. Unfortunately, side effect, some AEDs could contribute...
Embelin (2,5-dihydroxy-3-undecyl-1,4-benzoquinone) is one of the active components (2.3%) found in Embelia ribes Burm fruits. As determined via vitro AChE inhibition assay, embelin can inhibit acetylcholinesterase enzyme. Therefore, be utilized as a therapeutic compound, after further screening has been conducted for its use treatment Alzheimer's disease (AD). In this study, nootropic and anti-amnesic effects on scopolamine-induced amnesia rats were evaluated. Rats treated once daily with...
Glycyrrhizin (glycyrrhizic acid), a bioactive triterpenoid saponin constituent of Glycyrrhiza glabra, is traditional medicine possessing plethora pharmacological anti-inflammatory, antioxidant, antimicrobial, and antiaging properties. It known inhibitor high mobility group box 1 (HMGB1), ubiquitous protein with proinflammatory cytokine-like activity. HMGB1 has been implicated in an array inflammatory diseases when released extracellularly, mainly by activating intracellular signaling upon...
Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting senile population with manifestation of motor disability and cognitive impairment. Reactive oxygen species (ROS) implicated in progression oxidative stress-related apoptosis cell death midbrain dopaminergic neurons. Its interplay mitochondrial functionality constitutes an important aspect neuronal survival perspective PD. Edible bird's nest (EBN) animal-derived natural food product made saliva secreted by...
The frequency and magnitude of dengue epidemics continue to increase exponentially in Malaysia, with a shift the age range predominance toward adults an expansion rural areas. Despite this, information pertaining extent transmission virus (DENV) community is lacking. This community-based pilot study was conducted establish DENV seroprevalence amongst healthy district Southern identify influencing factors. In this undertaken between April May 2015, total 277 adult participants were recruited...
1. Homogeneous beta-bungarotoxin, isolated from the venom of Bungarus multicinctus was radiolabelled with N-succinimidyl-[2.3-(3) H]propionate. Stable, di-propionylated material obtained which tritiated on both subunits and had a specific radioactivity 102 Ci/mmol. 2. After separation unlabelled toxin by isoelectric focussing, it shown to exhibit significant biological activity in peripheral central nervous systems but negligible phospholipase A2 towards lecithin or cerebrocortical...