A5039528162- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Hemoglobinopathies and Related Disorders
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Systemic Sclerosis and Related Diseases
- Blood groups and transfusion
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Diabetes and associated disorders
- Neutropenia and Cancer Infections
- Prenatal Screening and Diagnostics
- Diabetes Management and Research
- Pancreatic function and diabetes
- Multiple Sclerosis Research Studies
- Kruppel-like factors research
- Eosinophilic Disorders and Syndromes
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Erythrocyte Function and Pathophysiology
- Polyomavirus and related diseases
- Childhood Cancer Survivors' Quality of Life
- T-cell and Retrovirus Studies
- Immune Cell Function and Interaction
Universidade de São Paulo
2015-2025
Universidade do Estado do Amazonas
2025
Clinics Hospital of Ribeirão Preto
2014-2024
Universidade de Ribeirão Preto
2013-2022
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2018-2022
Universidade Federal de Minas Gerais
2018
Sociedade Brasileira de Cardiologia
2017
Fundação de Amparo à Pesquisa do Estado de São Paulo
2017
National Council for Scientific and Technological Development
2017
University of Florida
2016
ContextType 1 diabetes mellitus (DM) results from a cell-mediated autoimmune attack against pancreatic beta cells. Previous animal and clinical studies suggest that moderate immunosuppression in newly diagnosed type DM can prevent further loss of insulin production reduce needs.ObjectiveTo determine the safety metabolic effects high-dose followed by autologous nonmyeloablative hematopoietic stem cell transplantation (AHST) DM.Design, Setting, ParticipantsA prospective phase 1/2 study 15...
Autologous hematopoietic stem cell transplantation (AHSCT) may be effective in aggressive forms of multiple sclerosis (MS) that fail to respond standard therapies.To evaluate the long-term outcomes patients who underwent AHSCT for treatment MS a large multicenter cohort.Data were obtained multicenter, observational, retrospective cohort study. Eligibility criteria receipt between January 1995 and December 2006 availability prespecified minimum data set comprising disease subtype at baseline;...
Abstract BACKGROUND Invasive infection by Fusarium sp. is associated with high mortality in patients hematologic cancer. Yet to the authors' knowledge, little known regarding predictors of adverse outcome. METHODS The authors conducted a retrospective review records carcinoma and invasive fusariosis who were treated at one institution U.S. 11 centers Brazil. RESULTS 84 evaluated. Neutropenia was present 83% 33 had undergone stem cell transplantation. Only 18 (21%) alive 90 days after...
Invasive fungal disease (IFD) shows distinct regional incidence patterns and epidemiological features depending on the geographic region. We conducted a prospective survey in eight centres Brazil from May 2007 to July 2009. All haematopoietic cell transplant (HCT) recipients patients with acute myeloid leukaemia (AML) or myelodysplasia (MDS) were followed admission until 1 year end of consolidation therapy (AML/MDS). The 12-month cumulative (CI) proven probable IFD was calculated, curves...
Haematopoietic stem cell transplantation has been proposed as treatment for mitochondrial neurogastrointestinal encephalomyopathy, a rare fatal autosomal recessive disease due to TYMP mutations that result in thymidine phosphorylase deficiency. We conducted retrospective analysis of all known patients suffering from encephalomyopathy who underwent allogeneic haematopoietic between 2005 and 2011. Twenty-four patients, 11 males 13 females, median age 25 years (range 10–41 years) treated with...
Autologous hematopoietic stem cell transplantation (AHSCT) increases C-peptide levels and induces insulin-independence in patients with type 1 diabetes. This study aimed to investigate how clinical outcomes may associate the immunological status, especially concerning balance between immunoregulation autoreactivity. Twenty-one diabetes were monitored after AHSCT, assessed every six months for duration of insulin independence, levels, frequencies islet-specific autoreactive CD8+ T-cells,...
Three randomized controlled trials in early severe systemic sclerosis demonstrated that autologous hematopoietic stem cell transplantation was superior to standard cyclophosphamide therapy. This European Society for Blood and Marrow Transplantation multi-center prospective non-interventional study designed further decipher efficacy safety of this procedure patients real-life practice search prognostic factors. All consecutive adult undergoing a first between December 2012 February 2016 were...
To evaluate the immunological mechanisms associated with clinical outcomes after autologous hematopoietic stem cell transplantation (AHSCT), focusing on regulatory T- (Treg) and B- (Breg) immune reconstitution, 31 systemic sclerosis (SSc) patients underwent simultaneous evaluations over 36-month posttransplantation follow-up. Patients were retrospectively grouped into responders (n = 25) nonresponders 6), according to response AHSCT. Thymic function B-cell neogenesis respectively assessed by...
We have determined the prevalence of methylenetetrahydrofolate reductase (MTHFR) mutations C677T and A1298C in 71 children ( 15 years) with acute lymphoblastic leukaemia (ALL) control subjects. Odds ratio (OR) for ALL linked to MTHFR was 0·4 (95% CI 0·2–0·8); heterozygotes it 0·5 0·2–0·9) homozygotes 0·3 (95%CI 0·09–0·8). yielded an overall OR 1·3 CI: 0·7–2·6); 0·7–7·6) 2·8 0·5–15·6). In conclusion, a significant 2·4‐fold decreased risk developing childhood ALL, whereas did not significantly...
Background: Neuromyelitis optica (NMO) is an inflammatory autoimmune disorder of the central nervous system, hallmarked by pathogenic anti-aquaporin 4 antibodies. NMO prognosis worse compared with multiple sclerosis. Objective: The European Group for Blood and Marrow Transplantation (EBMT) Autoimmune Diseases Working Party (ADWP) conducted a retrospective survey to analyze disease outcome following autologous stem cell transplantation (ASCT). Methods: This multicenter study assessed efficacy...
Oral mucositis (OM) affects patients who are submitted to hematopoietic stem cell transplantation (HSCT) due high doses of chemotherapy and/or radiotherapy. The purpose this investigation was perform a comparative study the frequency and evolution OM among subjected therapeutic laser conventional therapy (use mouthwash called 'Mucositis Formula'). were myeloablative conditioning regimen before allogeneic HSCT. Twenty-two selected divided into 2 groups: group I irradiated with InGaAlP (660...
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system, due to an immune reaction against myelin proteins. Multipotent mesenchymal stromal cells (MSCs) present immunosuppressive effects and have been used for treatment diseases. In our study, gene expression profile in vitro immunomodulatory function tests were compare bone marrow-derived MSCs obtained from MS patients, at pre- postautologous hematopoietic stem cell transplantation (AHSCT) with...
Abstract Invasive fungal disease (IFD) is frequent in patients with haematologic malignancies and recipients of haematopoietic cell transplantation (HCT). An epidemiologic study conducted Brazil reported a high incidence IFD patients, invasive fusariosis was the leading IFD. A limitation that galactomannan not available for at least half period. In order to characterise epidemiology burden three cohorts, HCT, acute myeloid leukaemia (AML) or myelodysplasia (MDS), lymphoid (ALL), we...