A5047940595- Immune Cell Function and Interaction
- Systemic Sclerosis and Related Diseases
- T-cell and B-cell Immunology
- Hematopoietic Stem Cell Transplantation
- CAR-T cell therapy research
- Inflammatory Myopathies and Dermatomyositis
- Immunotherapy and Immune Responses
- Autoimmune Bullous Skin Diseases
- Cytomegalovirus and herpesvirus research
- Cancer Immunotherapy and Biomarkers
- Mast cells and histamine
- Multiple Sclerosis Research Studies
- Diabetes and associated disorders
- Acute Myeloid Leukemia Research
- Skin Diseases and Diabetes
- Dermatologic Treatments and Research
- Reproductive System and Pregnancy
- Cancer Cells and Metastasis
- Adipokines, Inflammation, and Metabolic Diseases
- Hemoglobinopathies and Related Disorders
- Blood groups and transfusion
- Prenatal Screening and Diagnostics
- Polyomavirus and related diseases
- Chronic Lymphocytic Leukemia Research
- Systemic Lupus Erythematosus Research
Karolinska Institutet
2018-2025
PowerCell (Sweden)
2025
Universidade de São Paulo
2014-2020
Clinics Hospital of Ribeirão Preto
2014-2020
Institut Universitaire de France
2017
Inserm
2017
Fundação de Amparo à Pesquisa do Estado de São Paulo
2015-2016
Institute for Stem Cell Biology and Regenerative Medicine
2014
Autologous hematopoietic stem cell transplantation (AHSCT) increases C-peptide levels and induces insulin-independence in patients with type 1 diabetes. This study aimed to investigate how clinical outcomes may associate the immunological status, especially concerning balance between immunoregulation autoreactivity. Twenty-one diabetes were monitored after AHSCT, assessed every six months for duration of insulin independence, levels, frequencies islet-specific autoreactive CD8+ T-cells,...
To evaluate the immunological mechanisms associated with clinical outcomes after autologous hematopoietic stem cell transplantation (AHSCT), focusing on regulatory T- (Treg) and B- (Breg) immune reconstitution, 31 systemic sclerosis (SSc) patients underwent simultaneous evaluations over 36-month posttransplantation follow-up. Patients were retrospectively grouped into responders (n = 25) nonresponders 6), according to response AHSCT. Thymic function B-cell neogenesis respectively assessed by...
The determinants of clinical responses after autologous hematopoietic stem cell transplantation (aHSCT) in systemic sclerosis (SSc) are still unraveled. We analyzed long-term immune reconstitution (IR) and T receptor (TCR) repertoire diversity 10 SSc patients, with at least 6 years simultaneous immunological follow-up aHSCT. Patients were retrospectively classified as responders (A, n = 5) or non-responders (B, 5), using modified Rodnan’s skin score (mRSS) forced vital capacity (FVC%). All...
γδ T cells are clonotypically distinct in ascites and tumors of patients with ovarian cancer their functionality correlates clinical outcome.
Abstract Objectives The rationale of autologous haematopoietic stem cell transplantation (AHSCT) for autoimmune diseases is that high-dose immunosuppression eradicates autoreactive T and B cells the infused promote reconstitution a naïve self-tolerant immune system. aim this study was to evaluate different subsets, both quantitatively functionally, in SSc patients treated with AHSCT. Methods Peripheral blood harvested from 22 before at 30, 60, 120, 180 360 days post-AHSCT. Immunophenotyping...
Abstract Objectives The clinical outcome after allogeneic haematopoietic stem cell transplantation (aHCT) relies greatly on the efficient recovery of T cells. Several studies have investigated short‐term γδ reconstitution and their role in outcomes following transplantation. Nevertheless, long‐term characteristics impact remained largely unknown. Methods We analysed cells from 20 recipient/donor pairs at phenotypic, clonotypic functional levels to assess ≥ 8 years (median 18 years)...
Abstract Adoptive cell therapy using tumor-infiltrating lymphocytes (TILs) has shown remarkable efficacy in treating melanoma and other "hot" tumors characterized by high tumor mutation burden (TMB), a biomarker increasingly recognized for predicting immunotherapy success solid tumors. However, gliomas show no clear correlation between TMB due to the immunosuppressive microenvironment, defective antigen presentation restrictive blood-brain barrier, hindering effectiveness of immunotherapy....
Type 2 diabetes mellitus (T2D) is a metabolic disease with inflammation as an important pathogenic background. However, the pattern of immune cell subsets and cytokine profile associated development T2D are unclear. The objective this study was to evaluate different components system in patients' peripheral blood by quantifying frequency lymphocyte intracellular pro- anti-inflammatory production T cells. Clinical data samples were collected from 22 men (51.6±6.3 years old) 20 nonsmoking...
Abstract Although the impact of donor graft composition on clinical outcomes after hematopoietic stem cell transplantation (HSCT) has been studied, little is known about role intragraft γδ TCR repertoire following HSCT. Using a high-throughput sequencing platform, we sought to analyze γ-chain (TRG) T cells within grafts and address its potential response in corresponding patients. A total 20 peripheral blood were analyzed, donors classified as CMV+/−. The respective acute myeloid leukemia...
The role of gamma delta ( γδ ) T cells in human cytomegalovirus (HCMV) immune surveillance has been the focus research interest for years. Recent reports have shown a substantial clonal proliferation response to HCMV, shedding light on adaptive cells. Nevertheless, most efforts focused V δ 2 neg cell subset while less attention given investigate other common subsets. In this regard, distinct subpopulation that expresses CD8 coreceptor (CD8 + cells) not thoroughly explored. Whether it is...
Less than a third of patients with acute myeloid leukemia (AML) are cured by chemotherapy and/or hematopoietic stem cell transplantation, highlighting the need to develop more efficient drugs. The low efficacy standard treatments is associated inadequate depletion CD34+ blasts and leukemic cells, latter drug-resistant subpopulation cells characterized CD34+CD38- phenotype. To target these primitive better, we have designed CD34/CD3 bi-specific T-cell engager (BTE) its anti-leukemia potential...