A5001029181- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Hemoglobinopathies and Related Disorders
- Acute Myeloid Leukemia Research
- Childhood Cancer Survivors' Quality of Life
- Prenatal Screening and Diagnostics
- Chronic Lymphocytic Leukemia Research
- Mesenchymal stem cell research
- Renal and related cancers
- Chronic Myeloid Leukemia Treatments
- Oral health in cancer treatment
- Pluripotent Stem Cells Research
- Pharmacogenetics and Drug Metabolism
- Eosinophilic Disorders and Syndromes
- Heart Failure Treatment and Management
- Chemotherapy-induced organ toxicity mitigation
- Rural and Ethnic Education
- Neuroscience of respiration and sleep
- Blood disorders and treatments
- Iron Metabolism and Disorders
- Child Nutrition and Feeding Issues
- Breastfeeding Practices and Influences
- Blood groups and transfusion
- Neonatal Respiratory Health Research
- Immunodeficiency and Autoimmune Disorders
Hospital Samaritano de São Paulo
2017-2025
Support group for adolescents and children with cancer
2004-2025
Hospital de São João
2023
São Camilo Hospital
2020-2022
Universidade Federal de São Paulo
2004-2015
Instituto de Oncologia do Paraná
2013
Studies suggest that intraoral low-level laser therapy (LLLT) can ameliorate oral mucositis in adult patients receiving high-dose chemotherapy. The objective of this study was to evaluate the use a combined protocol and extraoral LLLT children undergoing hematopoietic stem cell transplantation (HSCT).Twelve HSCT were treated four times week with LLLT, for mean duration 22 days. Clinical functional scores assessed using National Cancer Institute Common Terminology Criteria Adverse Events...
In resource-limited countries, access to advanced therapies like CAR T-cell therapy is often unattainable. Clinical trials face challenges, with pediatric populations frequently excluded or experiencing significant delays. This highlights the need for alternative strategies address high relapse risks in acute leukemia post-stem cell transplant. retrospective study included patients who underwent HSCT between 2014 and 2024. Post-HSCT maintenance became standard practice 2021, utilizing agents...
Abstract Background Revaccination after hematopoietic stem cell transplantation ( HSCT ) is necessary to compensate for the loss of immunological memory. The aims this study were evaluate adherence revaccination schedule and humoral immune response different vaccine antigens in pediatric young adult patients. Methods Patients submitted over 3 years recruited. After written informed consent, a questionnaire was filled in, vaccination card analyzed, blood sample collected tested by ELISA...
In patients with established heart failure (HF) low total cholesterol levels associate worse prognosis. Evidence concerning the impact of Low-density lipoprotein (LDL-c) in HF is scarce. We aimed to evaluate prognostic LDL-c HF, both and without diabetes mellitus (DM). retrospectively analyzed outpatients chronic systolic dysfunction followed our clinic from January/2012 May/2018. was calculated using Friedewald's formula. Patients a complete lipid profile were excluded. The endpoint under...
Peripheral blood stem cell concentrations are traditionally adjusted to 20–40 × 106 leukocytes/mL prior freezing. This low concentration at cryopreservation implies larger volumes with more dimethyl sulfoxide being used, and higher cost toxicity the time of transplant. Higher have been reported but this is not widely accepted. Moreover, influence on engraftment has well documented. Therefore, study retrospectively analyzed peripheral freezing after autologous hematopoietic transplantation....
Abstract The choice of alternative donors for HCT patients without an HLA‐matched related donor depends on several factors. We compared major outcomes in 212 consecutive children transplanted at 11 centers Brazil acute leukemia or MDS from unrelated (MUD, n = 95), mismatched (MMUD, 47) umbilical cord blood (UCB, 70). Most had ALL (61%), bone marrow (57%) as the graft source and 95% received a MAC regimen. 3‐year OS probability were 57, 55, 37% after MUD, MMUD, UCB, respectively (HR 1.68,...
A Sociedade Brasileira de Transplante Medula (SBTMO) promoveu o I Encontro Diretrizes do Óssea em 2009. Para revisão das indicações transplante Pediatria baseadas evidências foi constituído grupo trabalho com oncologistas e hematologistas experiência pediatria. Os artigos científicos foram cuidadosamente avaliados e, para cada doença, definidas as recomendação dos transplantes (de a C) qualidade destas 1 3). As recomendações incluem doenças hematológicas malignas não malignas, tumores...
Allogeneic unrelated hematopoietic stem cell transplants (HSCT) are complex procedures that need adequate hospital infrastructure, a competent team, high-cost and medications. Most performed in Brazil paid by the government. The national health system reimburses U$ 35,801.00 as flat rate. government has recently increased this amount 60% but there not studies to use evaluate appropriateness of amount. objective study was retrospectively cost ten consecutive donor HSCT our institution....
THE BRAZILIAN SOCIETY FOR BLOOD AND MARROW TRANSPLANTATION (SBTMO) PRESENTS GUIDELINES ON HEMATOPOIETIC STEM CELL
Hematopoietic stem cell transplantation (HSCT) offers the opportunity for cure to patients with malignant and non-malignant diseases. Given myriad advances in past few decades, coupled rising numbers of transplants worldwide, number long-term survivors, many whom are free disease which they were transplanted, is constantly increasing. Despite improved prognosis observed overall, outcome may be undermined by transplant-associated morbidity mortality. Long-term survivors present a variety...

 In addition to the chronic myeloid leukemia (CML) BCR-ABL1+, classic myeloproliferative neoplasms include polycythemia vera, essential thrombocythemia and primary myelofibrosis. These have a very low incidence in pediatric age group there is no consensus on treatment children.
Busulfan (bu) is one of the most used chemotherapy in conditioning regimens for patients submitted to hematopoietic cell transplantation (HCT). As Bu pharmacokinetic (PK) widely variable, dose adjustment according patient PK has been shown minimize toxicities improving clinical outcome. Usually, calculated from blood samples collected after first dose, guiding following doses. Although this method be reliable, it can difficult perform an optimal time frame.
Relapse of a malignant hematological disease after allogeneic HCT is associated with poor survival and may not be treated curative intent. However, second (HCT2) achieve durable remission. To determine the outcomes pediatric patients who received HCT2 for relapsed diseases. Review medical records underwent diseases in two institutions from 2013 to 2023. OS was estimated using Kaplan-Meier analysis. The conventional Comorbidity index (HCT-CI) calculated all...
Indivíduos diagnosticados com Leucemia Miel ide Aguda (LMA) podem apresentar manifestações bucais decorrentes da doença e manifestaões consequentes ao tratamento de quimioterapia radioterapia. Relato Caso: Paciente do gênero masculino, três anos, diagnosticado Mielóide refratária, diabetes mellitus tipo1 (DM1) hipotireoidismo. Recebeu transplante células-tronco hematopoiéticas (TCTH) alogênico não aparentado. No controle DM1 foi utilizada terapia infusão contínua insulina subcutânea bomba...