A5039829659- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- Folate and B Vitamins Research
- Inflammatory Bowel Disease
- Trace Elements in Health
- Hematopoietic Stem Cell Transplantation
- Blood groups and transfusion
- Cancer Treatment and Pharmacology
- Palliative and Oncologic Care
- Autoimmune and Inflammatory Disorders
- Multiple Myeloma Research and Treatments
- Liver Disease Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Pharmacogenetics and Drug Metabolism
- Mast cells and histamine
- Palliative Care and End-of-Life Issues
Hospital Israelita Albert Einstein
2008-2020
ABSTRACT Objectives: To evaluate the use of magnetic resonance imaging in patients with β-thalassemia and to compare T2* results serum ferritin levels redox active fraction labile plasma iron. Methods: We have retrospectively evaluated 115 chronically transfused (65 women). tested chemiluminescence, iron by cellular fluorescence used MRI assess content heart, liver, pancreas. Hepatic concentration was determined liver biopsies 11 were compared imaging. Results: The mean 2,676.5 +/- 2,051.7...
Descrever a eficácia da quimioterapia nos cuidados paliativos em pacientes oncológicos. Trata-se de um estudo revisão integrativa iniciado abril 2020, que utilizou como base dados o Google Acadêmico, Medline, Scielo e PubMed. A estratégia PICO foi utilizada para construção dos temas pesquisa. De acordo com este método busca, chegou-se 255 artigos, definição por determinação critérios exclusão foram selecionados 27 artigos originais utilizados nessa revisão. Os analisados organizados quatro...
Background Crohn's disease (CD) is a chronic inflammatory and relapsing that can affect any segment of the gastrointestinal tract. A significant percentage these patients suffer an aggressive course, refractory to conventional clinical therapy . Surgery may be required, however tends recur after resection. Aim Describe potential benefit autologous hematopoietic stem cell with T-lymphocyte-depletion as treatment for CD patients. Evaluate its efficacy, safety, toxicity adverse events primary...
Busulfan (bu) is one of the most used chemotherapy in conditioning regimens for patients submitted to hematopoietic cell transplantation (HCT). As Bu pharmacokinetic (PK) widely variable, dose adjustment according patient PK has been shown minimize toxicities improving clinical outcome. Usually, calculated from blood samples collected after first dose, guiding following doses. Although this method be reliable, it can difficult perform an optimal time frame.
A significant percentage of Crohn’s disease (CD) patients suffer an aggressive course, refractory to available approved medical therapies. Increasing evidence supports Autologous Haematopoietic Stem Cell Transplantation (AHSCT) could be a therapeutic option.1 Six between 19 years and 43 years, with CD were submitted AHSCT. Median course illness was 14 (5–23 years) all negative for X-linked inhibitor apoptosis protein (XIAP). Four had penetrating two non-stricturing, non-penetrating...