A5076204813- Childhood Cancer Survivors' Quality of Life
- Sarcoma Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Neuroblastoma Research and Treatments
- Congenital Diaphragmatic Hernia Studies
- Soft tissue tumor case studies
- Hematological disorders and diagnostics
- Chromatin Remodeling and Cancer
- Hematopoietic Stem Cell Transplantation
- CAR-T cell therapy research
- Muscle and Compartmental Disorders
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Neutropenia and Cancer Infections
- Epilepsy research and treatment
- Nanowire Synthesis and Applications
- Testicular diseases and treatments
- Global Cancer Incidence and Screening
- COVID-19 Clinical Research Studies
- Tumors and Oncological Cases
- Metastasis and carcinoma case studies
- Transplantation: Methods and Outcomes
- Adolescent and Pediatric Healthcare
- COVID-19 and healthcare impacts
Tata Medical Center
2018-2024
Aster Medcity
2018-2020
Regional Cancer Center, Thiruvananthapuram
2014-2016
We report a case of 9-year-old boy with glioblastoma past history colon cancer. Germline bi-allelic DNA-mismatch repair deficiency was diagnosed by lack immunohistochemical staining for PMS2 in the tumor and normal tissue. Family lacking. Sequencing confirmed compound heterozygous mutations. A second hit DNA-polymerase-ε gene led to complete DNA-replication deficiency. This contributed an ultra-hypermutated phenotype. Temozolomide excluded from treatment. PD-1 immunotherapy at recurrence...
Childhood cancer often involves a long-term engagement of children and their parents with health services. During this journey, communications between professionals, young people can be stressful for all the stakeholders. This study explores communication preferences in paediatric oncology.The objective present exploratory qualitative was to understand views professionals regarding information exchange during treatment complement these findings clinic-based ethnographic observation real-life...
Abstract Extrapulmonary DICER1 ‐associated sarcomas (DS) can harbor morphological features overlapping with pleuropulmonary blastoma. We report three children intracranial and genital tract sarcomas, suspected to have DS based on a heterogeneous yet defining combination of spindle‐cell sarcomatous blastemal morphology, rhabdomyomatous differentiation. Foci immature cartilage at diagnosis ( n = 2/3) increased neuroepithelial differentiation recurrence 1) were noted. Morphological suspicion...
SMARCB1/integrase interactor (INI)-1 is one of the core subunit proteins ATP-dependent SWI/SNF chromatin remodeling complex and acts as a tumor suppressor. INI-1 loss can be easily assessed using immunohistochemistry an important diagnostic clue for histopathologist. Chordoma malignant commonly occurring in sacrococcygeal spine adults characterized by nuclear expression brachyury. Poorly differentiated chordoma, morphologically molecularly distinct entity, also shows brachyury positivity...
Background: Constitutional mismatch-repair deficiency (CMMRD) is an aggressive cancer-predisposition syndrome caused by biallelic pathogenic variants in PMS2, MSH6, MLH1, and MSH2. Lack of robust data on the true clinical-spectrum, cancer-biology, genotype-phenotype associations result challenges management inferior patient outcomes.Methods: The International Replication-Repair Deficiency Consortium performed comprehensive clinical molecular analyses for CMMRD patients longitudinally between...
Haplo-identical peripheral blood stem cell transplant(PBSCT) has become the preferred alternative donor transplant program in most centers India owing to its logistic and cost advantages. Myeloablative conditioning proposes reduce relapse rate at marginal of an increase related morbidity mortality. This study is a retrospective analysis 43 patients suffering from high risk hematological malignancies (AML-27, ALL-4, NHL-2, CML-6, Blastic Plasmacytoid Dendritic Leukemia-1, Plasmablastic...