A5032782498- Advancements in Transdermal Drug Delivery
- Antimicrobial Resistance in Staphylococcus
- Dermatology and Skin Diseases
- Antibiotics Pharmacokinetics and Efficacy
- Plasma Diagnostics and Applications
- Contact Dermatitis and Allergies
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- Clostridium difficile and Clostridium perfringens research
- Antibiotic Resistance in Bacteria
- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Geophysics and Sensor Technology
- Antifungal resistance and susceptibility
- Viral gastroenteritis research and epidemiology
- Microscopic Colitis
- Pharmaceutical studies and practices
- Streptococcal Infections and Treatments
- Planetary Science and Exploration
- Escherichia coli research studies
- Urinary Tract Infections Management
- Surfactants and Colloidal Systems
- Patient Satisfaction in Healthcare
- Genetic factors in colorectal cancer
- Inhalation and Respiratory Drug Delivery
University of Colorado Denver
2016-2025
Children's Hospital Colorado
2023-2025
United States Department of Veterans Affairs
2020-2025
Veterans Health Administration
2020-2025
Oregon Health & Science University
2022-2024
University of Montana
2022-2024
Doernbecher Children's Hospital
2022-2024
University of Kansas Medical Center
2023-2024
University of Colorado Hospital
2016-2023
Riley Hospital for Children
2023
SUMMARY Recurrent epidemics of influenza are observed seasonally around the world with considerable health and economic consequences. A key quantity for control infectious diseases is reproduction number, which measures transmissibility a pathogen determines magnitude public interventions necessary to epidemics. Here we applied simple epidemic model weekly indicators mortality estimate numbers seasonal spanning three decades in United States, France, Australia. We found similar distributions...
Cyclooxygenase inhibitors prevent the pulmonary vasomotor changes in response to low-dose endotoxin. We, therefore, explored role of two highly vasoactive prostanoids, thromboxane A2, a vasoconstrictor, and prostacyclin, vasodilator, transient vasoconstriction subsequent loss alveolar hypoxis (AHPV) that follows AHPV was tested dog with double-lumened endotracheal tube allowing ventilation one lung nitrogen as hypoxic challenge while other ventilated oxygen maintain systemic oxygenation....
The expansion of native mass spectrometry (MS) methods for both academic and industrial applications has created a substantial need analysis large MS datasets. Existing software tools are poorly suited high-throughput deconvolution electrospray spectra from intact proteins protein complexes. UniDec Bayesian algorithm is uniquely well due to its speed robustness but was previously tailored towards individual spectra. Here, we optimized deconvolution, analysis, visualization data sets. This...
Long-acting lipoglycopeptides (laLGPs) are FDA approved only for acute bacterial skin and structure infections (ABSSSIs). However, these antibiotics show promise off-label use, reductions in hospital length of stay (LOS) healthcare cost savings.To assess the effectiveness, safety, impact on LOS estimated savings from laLGP treatment Gram-positive infections.Retrospective cohort adult patients who received at least one dose laLGPs University Colorado Health system. Descriptive statistics were...
Pediatric brain tumors are the leading cause of cancer-related death in children United States and contribute a disproportionate number potential years life lost compared to adult cancers. Moreover, survivors frequently suffer long-term side effects, including secondary The Children's Brain Tumor Network (CBTN) is multi-institutional international clinical research consortium created advance therapeutic development through collection rapid distribution biospecimens data via open-science...
Abstract Background Pathology and Monkeypox virus (MPXV) tissue tropism in severe fatal human mpox is not thoroughly described but can help elucidate the disease pathogenesis role of coinfections immunocompromised patients. Methods We analyzed biopsy autopsy tissues from 22 patients with or outcomes to characterize pathology viral antigen DNA distribution by immunohistochemistry situ hybridization. Tissue-based testing for was also performed. Results Mucocutaneous lesions showed necrotizing...
Background: We sought to define the rate of syndesmotic instability after anatomic reduction posterior malleolus when stabilization a trimalleolar or equivalent ankle fracture was chosen vs supine position and initially conservative management elements chosen. Methods: The types malleolar fixation used treat adult patients with fractures involving at our level I trauma center were retrospectively assessed (N = 198). Specifically, both bimalleolar included. Exclusion criteria included pilon...
Abstract Background Injection drug use is associated with serious infections. Due to challenges medical management of addiction, relapses and additional infections are common. Persons who drugs (PWUD) more likely leave against advice before completing treatment, which could result in treatment failure. Prolonged intravenous (IV) antimicrobial therapy PWUD may be complicated by concern for IV catheter misuse, sometimes requiring prolonged hospitalization. Ideal alternatives would provide the...
Abstract Background Oritavancin, a long-acting lipoglycopeptide approved for use in acute bacterial skin and structure infections, has limited data evaluating serious infections due to Gram-positive organisms. We aimed assess the effectiveness safety of oritavancin consolidative treatment bloodstream (BSI), including infective endocarditis (IE). Methods conducted retrospective cohort study adult patients admitted University Colorado Hospital from March 2016 January 2022 who received ≥ 1 dose...
Myosin-VI has been implicated in endocytic trafficking at both the clathrin-coated and uncoated vesicle stages. The identification of alternative splice forms led to suggestion that splicing defines type which myosin-VI is recruited. In contrast this hypothesis, we find all cell types examined, associated with vesicles, regardless form. GIPC, a PDZ-domain containing adapter protein, co-assembles on these vesicles. only recruited vesicles cells express high levels Dab2, clathrin-binding...
Abstract Background Several barriers to antimicrobial stewardship (ASP) in various Colorado hospitals were previously identified, including lack of clinical pathways, antibiotic dosing knowledge neonatal and pediatric populations, understanding methodologies. We sought mitigate robust ASP through creation a mobile application decision support system, Firstline (www.Firstline.org). Our objective is describe the uptake, usage patterns, satisfaction across state. Figure 1 Run chart monthly...