Shannon Robins
A5034308933- Hedgehog Signaling Pathway Studies
- Epigenetics and DNA Methylation
- Glioma Diagnosis and Treatment
- Renal and related cancers
- Medical Imaging Techniques and Applications
- Neuroblastoma Research and Treatments
- RNA modifications and cancer
- Food Security and Health in Diverse Populations
- Cancer Genomics and Diagnostics
- Health and Medical Research Impacts
- Rangeland and Wildlife Management
- Poverty, Education, and Child Welfare
- Adolescent Sexual and Reproductive Health
- Pancreatic and Hepatic Oncology Research
- Advances in Oncology and Radiotherapy
Children's Hospital of Philadelphia
2022-2023
Temple University Health System
2017
Fox Chase Cancer Center
2017
Pediatric brain tumors are the leading cause of cancer-related death in children United States and contribute a disproportionate number potential years life lost compared to adult cancers. Moreover, survivors frequently suffer long-term side effects, including secondary The Children's Brain Tumor Network (CBTN) is multi-institutional international clinical research consortium created advance therapeutic development through collection rapid distribution biospecimens data via open-science...
Pediatric brain and spinal cancers are collectively the leading disease-related cause of death in children; thus, we urgently need curative therapeutic strategies for these tumors. To accelerate such discoveries, Children's Brain Tumor Network (CBTN) Pacific Neuro-Oncology Consortium (PNOC) created a systematic process tumor biobanking, model generation, sequencing with immediate access to harmonized data. We leverage data establish OpenPBTA, an open collaborative project over 40 scalable...
Astrocytes, the most abundant type of glial cells in brain, play critical roles supporting neuronal development and brain function. Although astrocytes have been frequently detected tumors, including medulloblastoma (MB), their functions tumorigenesis are not clear. Here, we demonstrate that essential components MB tumor microenvironment. Tumor-associated (TAA) secrete ligand sonic hedgehog (Shh), which is required for maintaining cell proliferation despite absence its primary receptor...
Summary Pediatric brain and spinal cancer are the leading disease-related cause of death in children, thus we urgently need curative therapeutic strategies for these tumors. To accelerate such discoveries, Children’s Brain Tumor Network Pacific Neuro-Oncology Consortium created a systematic process tumor biobanking, model generation, sequencing with immediate access to harmonized data. We leverage data create OpenPBTA, an open collaborative project which establishes over 40 scalable analysis...
Abstract Pediatric brain tumors are the leading cause of cancer-related death in children United States and contribute a disproportionate number potential years life lost compared to adult cancers. Moreover, survivors frequently suffer long-term side effects, including secondary The Children’s Brain Tumor Network (CBTN) is multi-institutional international clinical research consortium created advance therapeutic development through collection rapid distribution biospecimens data via...
<div>Abstract<p>Astrocytes, the most abundant type of glial cells in brain, play critical roles supporting neuronal development and brain function. Although astrocytes have been frequently detected tumors, including medulloblastoma (MB), their functions tumorigenesis are not clear. Here, we demonstrate that essential components MB tumor microenvironment. Tumor-associated (TAA) secrete ligand sonic hedgehog (Shh), which is required for maintaining cell proliferation despite...
<div>Abstract<p>Astrocytes, the most abundant type of glial cells in brain, play critical roles supporting neuronal development and brain function. Although astrocytes have been frequently detected tumors, including medulloblastoma (MB), their functions tumorigenesis are not clear. Here, we demonstrate that essential components MB tumor microenvironment. Tumor-associated (TAA) secrete ligand sonic hedgehog (Shh), which is required for maintaining cell proliferation despite...
<p>MB cells can not maintain Gli1 expression in vitro</p>
<p>Apoptosis in MB slice culture</p>
<p>Legend for supplementary figures</p>
<p>GCV treatment did not affect MB cell survival</p>
<p>MB cells can not maintain Gli1 expression in vitro</p>
<p>Astrocytes are present in Shh type MB</p>
<p>Nestin expression was not induced in Ptch1-deficient GNPs after Gli1 overexpression</p>
<p>Legend for supplementary figures</p>
<p>Apoptosis in MB slice culture</p>
<p>Astrocytes are present in Shh type MB</p>
<p>Nestin expression was not induced in Ptch1-deficient GNPs after Gli1 overexpression</p>
<p>GCV treatment did not affect MB cell survival</p>
Abstract Background: Literature has shown that racial, ethnic, and gender disparities exist among clinical research participants within the ranks of academic institutions. To assess this develop solutions to potential in pediatric neuro-oncology, Pacific Pediatric Neuro-Oncology Consortium (PNOC) Children's Brain Tumor Network (CBTN) Diversity, Equity, Inclusion (DEI) working group distributed a survey all members consortia regarding state DEI our environments. In parallel, collated data...