A5067819319- Hedgehog Signaling Pathway Studies
- Glioma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Renal and related cancers
- Reconstructive Facial Surgery Techniques
- Reconstructive Surgery and Microvascular Techniques
- Facial Nerve Paralysis Treatment and Research
- Dermatologic Treatments and Research
- Tumors and Oncological Cases
- Facial Rejuvenation and Surgery Techniques
- Microtubule and mitosis dynamics
- Ferroptosis and cancer prognosis
- Chromatin Remodeling and Cancer
- Silk-based biomaterials and applications
- Cancer-related molecular mechanisms research
- Cellular Mechanics and Interactions
- Neurogenesis and neuroplasticity mechanisms
- Genetic and Kidney Cyst Diseases
- Cleft Lip and Palate Research
- Wound Healing and Treatments
- Laser Applications in Dentistry and Medicine
- Nasal Surgery and Airway Studies
- Cancer-related Molecular Pathways
- Cancer, Stress, Anesthesia, and Immune Response
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
Fox Chase Cancer Center
2014-2024
Temple University Health System
2014-2024
Peking Union Medical College Hospital
2015-2024
Dynamique du noyau
2024
Epigenomics (Germany)
2024
Academia Sinica
2023
Plastic Surgery Hospital
2019-2023
Soochow University
2017-2019
People’s Hospital of Rizhao
2017
Tumor cells are characterized by unlimited proliferation and perturbed differentiation. Using single-cell RNA sequencing, we demonstrate that tumor in medulloblastoma (MB) retain their capacity to differentiate a similar way as normal originating cells, cerebellar granule neuron precursors. Once they differentiate, MB permanently lose proliferative tumorigenic potential. Differentiated highly express NeuroD1, helix-loop-helix transcription factor, forced expression of NeuroD1 promotes the...
Astrocytes, the most abundant type of glial cells in brain, play critical roles supporting neuronal development and brain function. Although astrocytes have been frequently detected tumors, including medulloblastoma (MB), their functions tumorigenesis are not clear. Here, we demonstrate that essential components MB tumor microenvironment. Tumor-associated (TAA) secrete ligand sonic hedgehog (Shh), which is required for maintaining cell proliferation despite absence its primary receptor...
Purpose: The role of cholesterol biosynthesis in hedgehog pathway activity and progression medulloblastoma (Hh-MB) were examined vivo Statins, commonly used cholesterol-lowering agents, utilized to validate as a therapeutic target for Hh-MB.Experimental Design: Bioinformatic analysis was performed evaluate the association between with group human biospecimens. Alterations signaling evaluated cells after inhibition biosynthesis. endogenous mice genetic blockage tumor cells. Statins alone, or...
Astrocytes, a major glial cell type in the brain, play critical role supporting progression of medulloblastoma (MB), most common malignant pediatric brain tumor. Through lineage tracing analyses and single-cell RNA sequencing, we demonstrate that astrocytes are predominantly derived from transdifferentiation tumor cells relapsed MB (but not primary MB), although generally believed to be neuronal-lineage committed. Such relies on Sox9, transcription factor for gliogenesis. Our studies further...
Studying the early stages of cancer can provide important insight into molecular basis disease. We identified a preneoplastic stage in patched ( ptc ) mutant mouse, model for brain tumor medulloblastoma. Preneoplastic cells (PNCs) are found most mutants during adulthood, but only 15% these animals develop tumors. Although PNCs mice that tumors, ability to give rise tumors has never been demonstrated directly, and fate do not form remains unknown. Using genetic mapping orthotopic...
// Hoi-Yee Chow 1, * , Biao Dong 2, Sergio G. Duron 3 David A. Campbell Christy C. Ong 4 Klaus P. Hoeflich Long-Sheng Chang 5, 6, 7 D. Bradley Welling Zeng-jie Yang 1 Jonathan Chernoff Cancer Biology Program, Fox Chase Center, Philadelphia, Pennsylvania 19111, USA 2 Department of Microbiology and Immunology, Sol Sherry Thrombosis Research Temple University, 19104, Afraxis Inc., La Jolla, California 92037, Translational Oncology, Genentech, South San Francisco, 94080, 5 Center for Childhood...
Abstract The intermediate filament protein Nestin serves as a biomarker for stem cells and has been used to identify subsets of cancer stem–like cells. However, the mechanistic contributions pathogenesis are not understood. Here, we report that binds hedgehog pathway transcription factor Gli3 mediate development medulloblastomas subtype. In mouse model system, levels increased progressively during medulloblastoma formation, resulting in enhanced tumor growth. Conversely, loss dramatically...
Abstract Nestin, a class IV intermediate filament protein, is generally considered as putative marker of neural stem and progenitor cells in the central nervous system. Glioma common type adult brain tumors, glioblastoma (GBM) represents most aggressive form glioma. Here, we report that Nestin expression significantly upregulated human GBM, compared with other types knockdown or deletion U251 tumor from GBM patients derived xenografts resulted G2–M arrest, finally leading to apoptosis cells....
Medulloblastoma is one of the most prevalent brain tumors in children. Aberrant hedgehog (Hh) pathway signaling thought to be involved initiation and development medulloblastoma. Vismodegib, first FDA-approved cancer therapy based on inhibition aberrant signaling, targets smoothened (Smo), a G-protein coupled receptor (GPCR) central Hh pathway. Although vismodegib exhibits promising therapeutic efficacy tumor treatment, concerns have been raised from its nonlinear pharmacokinetic (PK)...
Neuronal polarization is pivotal for neural network formation during brain development. Axon differentiation a hallmark of initial neuronal polarization. Here, we report that the leucine-rich repeat-containing protein netrin-G ligand-2 (NGL-2) as polarity regulator localizes asymmetrically in rat hippocampal neurons and required future axon. NGL-2 was associated with PAR complex, this interaction resulted local stabilization axonal microtubules. Further study showed C terminal binds to PDZ...
Here, we examined the role of leukotrienes, well-known inflammatory mediators, in tumorigenesis hedgehog pathway-associated medulloblastoma, and tested efficacies antagonists leukotriene biosynthesis medulloblastoma treatment.Experimental Design: We levels cells by ELISA. next whether synthesis relied on activation pathway, or presence ligand secreted astrocytes. then investigated mediated hedgehog-induced Nestin expression tumor cells. The functions cell proliferation growth were determined...