A5077025884- Glioma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Genomics and Phylogenetic Studies
- Cancer Genomics and Diagnostics
- Cognitive Science and Mapping
- Developmental Biology and Gene Regulation
- Epigenetics and DNA Methylation
- Pluripotent Stem Cells Research
- TGF-β signaling in diseases
- Fungal and yeast genetics research
- Chromosomal and Genetic Variations
- Bioinformatics and Genomic Networks
- Pancreatic and Hepatic Oncology Research
- Advanced biosensing and bioanalysis techniques
- Sugarcane Cultivation and Processing
- Soil Carbon and Nitrogen Dynamics
- Plant Virus Research Studies
- Protein Structure and Dynamics
- Genetics, Bioinformatics, and Biomedical Research
- Rice Cultivation and Yield Improvement
- CRISPR and Genetic Engineering
- RNA modifications and cancer
Children's Hospital of Philadelphia
2021-2023
Drexel University
2021-2022
New Bulgarian University
2016-2018
University of California, Irvine
2016
University of Puget Sound
2011-2012
University of Toronto
2008
Gold standard datasets on protein complexes are key to inferring and validating protein-protein interactions.Despite much progress in characterizing the yeast Saccharomyces cerevisiae, numerous researchers still use as reference manually curated catalogued by Munich Information Center of Protein Sequences database.Although this catalogue has served community extremely well, it no longer reflects current state knowledge.Here, we report two catalogues results systematic curation efforts.The...
Pediatric brain and spinal cancers are collectively the leading disease-related cause of death in children; thus, we urgently need curative therapeutic strategies for these tumors. To accelerate such discoveries, Children's Brain Tumor Network (CBTN) Pacific Neuro-Oncology Consortium (PNOC) created a systematic process tumor biobanking, model generation, sequencing with immediate access to harmonized data. We leverage data establish OpenPBTA, an open collaborative project over 40 scalable...
ABSTRACT The concept of a morphogen – molecule that specifies two or more cell fates in concentration-dependent manner is paradigmatic developmental biology. Much remains unknown, however, about the existence morphogens developing vertebrate central nervous system (CNS), including mouse dorsal telencephalic midline (DTM). Bone morphogenetic proteins (BMPs) are candidate DTM morphogens, and our previous work demonstrated BMP4 sufficiency to induce one fate choroid plexus epithelial cells...
Abstract Identification of structural variants (SVs) breakpoints is important in studying mutations, mutagenic causes, and functional impacts. Next-generation sequencing whole-genome optical mapping are extensively used SV discovery characterization. However, multiple platforms computational approaches needed for comprehensive analysis, making it resource-intensive expensive. Here, we propose a strategy combining cas9-assisted targeted nanopore to analyze SVs. Optical can economically...
Summary Pediatric brain and spinal cancer are the leading disease-related cause of death in children, thus we urgently need curative therapeutic strategies for these tumors. To accelerate such discoveries, Children’s Brain Tumor Network Pacific Neuro-Oncology Consortium created a systematic process tumor biobanking, model generation, sequencing with immediate access to harmonized data. We leverage data create OpenPBTA, an open collaborative project which establishes over 40 scalable analysis...
Abstract Pediatric brain tumors comprise a heterogeneous molecular and histological landscape that challenges most current precision-medicine approaches. While recent large-scale efforts to molecularly characterize distinct entities have dramatically advanced the field’s capacity classify further define subtypes, developing therapeutic less toxic molecularly-defined clinical approaches remains challenge. To new meet these advance scalable, shared biospecimen- data-resources for pediatric...