Derek Hanson
A5073819910- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Cancer, Hypoxia, and Metabolism
- Viral-associated cancers and disorders
- Chromatin Remodeling and Cancer
- Epigenetics and DNA Methylation
- ATP Synthase and ATPases Research
- Cancer Mechanisms and Therapy
- Medical Imaging Techniques and Applications
- Protein Degradation and Inhibitors
- SARS-CoV-2 and COVID-19 Research
- Ocular Oncology and Treatments
- Hedgehog Signaling Pathway Studies
- Histone Deacetylase Inhibitors Research
- Cancer Research and Treatments
- Sarcoma Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Brain Metastases and Treatment
- Amino Acid Enzymes and Metabolism
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Lung Cancer Research Studies
- Cancer Cells and Metastasis
Seton Hall University
2020-2024
Hackensack University Medical Center
2018-2024
Center for Discovery
2020-2024
St. Joseph’s Children’s Hospital
2019-2024
Hackensack Meridian Health
2020-2024
Farmingdale State College
2023
Access to Advanced Health Institute
2022
Cohen Children's Medical Center
2015-2020
Schneider Children's Hospital
2015-2020
University of Washington
2017-2020
We report a comprehensive proteogenomics analysis, including whole-genome sequencing, RNA and proteomics phosphoproteomics profiling, of 218 tumors across 7 histological types childhood brain cancer: low-grade glioma (n = 93), ependymoma (32), high-grade (25), medulloblastoma (22), ganglioglioma (18), craniopharyngioma (16), atypical teratoid rhabdoid tumor (12). Proteomics data identify common biological themes that span boundaries, suggesting treatments used for one type may be applied...
Pediatric brain tumors are the leading cause of cancer-related death in children United States and contribute a disproportionate number potential years life lost compared to adult cancers. Moreover, survivors frequently suffer long-term side effects, including secondary The Children's Brain Tumor Network (CBTN) is multi-institutional international clinical research consortium created advance therapeutic development through collection rapid distribution biospecimens data via open-science...
Long-term survival in high-risk neuroblastoma (HRNB) is approximately 50%, with mortality primarily driven by relapse. Eflornithine (DFMO) to reduce risk of relapse after completion immunotherapy was investigated previously a single-arm, phase II study (NMTRC003B; ClinicalTrials.gov identifier: NCT02395666) that suggested improved event-free (EFS) and overall (OS) compared historical rates III trial (Children Oncology Group ANBL0032; NCT00026312). Using patient-level data from ANBL0032 as an...
Pediatric brain and spinal cancers are collectively the leading disease-related cause of death in children; thus, we urgently need curative therapeutic strategies for these tumors. To accelerate such discoveries, Children's Brain Tumor Network (CBTN) Pacific Neuro-Oncology Consortium (PNOC) created a systematic process tumor biobanking, model generation, sequencing with immediate access to harmonized data. We leverage data establish OpenPBTA, an open collaborative project over 40 scalable...
The microtubule inhibitor vincristine is currently used to treat a variety of brain tumors, including low-grade glioma and anaplastic oligodendroglioma. Vincristine, however, does not penetrate well into tumor tissue, moreover, it displays dose-limiting toxicities, peripheral neuropathy. Mebendazole, Food Drug Administration-approved anthelmintic drug with favorable safety profile, has recently been shown display strong therapeutic efficacy in animal models both medulloblastoma. Importantly,...
Human herpesvirus-6A and -6B (HHV-6) are betaherpesviruses that reach > 90% seroprevalence in the adult population. Unique among human herpesviruses, HHV-6 can integrate into subtelomeric regions of chromosomes; when this occurs germ line cells it causes a condition called inherited chromosomally integrated (iciHHV-6). Only two complete genomes available for replicating HHV-6B, leading to numerous conflicting annotations little known about global genomic diversity ubiquitous virus. Using...
Pediatric intracranial ependymoma has seen a recent exponential expansion of biological findings, rapidly dividing the diagnosis into several subgroups, each with specific molecular and clinical characteristics. While such subdivision may complicate conclusions from historical trials, this knowledge also provides an opportunity for interrogating major questions preventing near-term translation effective therapy children ependymoma. In article, we briefly review some most critical facing both...
Abstract Background Embryonal tumor with multilayered rosettes (ETMR) is a deadly grade IV pediatric brain tumor. Despite an intensive multimodal treatment approach that includes surgical resection, high‐dose chemotherapy, and radiotherapy, the progression‐free survival at 5 years less than 30%. Case We report case of long‐term in 5‐month old female large mass posterior fossa, diagnosed as ETMR, which subsequently underwent treatment‐induced maturation. Prior to histopathology revealed...
Why, when, and how to consider external control cohorts in pediatric brain tumor clinical trials.
Abstract Two children presented with a history of fever and rash. Lab values revealed pancytopenia, elevated ferritin, coagulopathy, triglycerides. Both quickly developed respiratory distress hypotension requiring admission to the ICU. Bone marrow biopsies hemophagocytosis. Studies for Ehrlichia returned positive. The patients were started on doxycycline treated hemophagocytic lymphohistiocytosis (HLH). Each made full recovery. In both patients, testing MUNC perforin genes found have no...
Quantitative PCR is a diagnostic pillar for clinical virology testing, and reference materials are necessary accurate, comparable quantitation between laboratories. Accurate of human herpesvirus 6A/B (HHV-6A/B) important detection viral reactivation inherited chromosomally integrated HHV-6A/B in immunocompromised patients. Reference commonly consist laboratory-adapted strains that may be affected by the culture process. We performed next-generation sequencing to make relative copy number...
Embryonal tumor with multilayer rosettes (ETMR) is a rare CNS malignancy affecting young children that carries very poor prognosis. Treatment intensive surgical resection, radiotherapy, and high-dose chemotherapy insufficient treatment in the vast majority of cases. Effective, biologically based therapies for this are therefore desperately needed. The Dana-Farber Cancer Institute-modified IRS-III protocol incorporates preclinically active agents, such as doxorubicin actinomycin D, into...
Abstract Purpose: Placental growth factor (PlGF) and its receptor neuropilin 1 are elevated in malignant embryonal tumors mediate tumor progression by promoting cell proliferation, survival, metastasis. TB-403 is a blocking monoclonal antibody against PlGF that inhibits increases survival orthotopic medulloblastoma models. Patients Methods: We conducted phase I, open-label, multicenter, dose-escalation study of pediatric subjects with relapsed or refractory cancers. The involved four dose...
Abstract Background High‐grade gliomas (HGG) have a dismal prognosis despite multimodal therapy. Mebendazole is an anti‐helminthic benzimidazole that has demonstrated efficacy in numerous vitro cancer models, and able to cross the blood–brain barrier. We conducted phase 1 trial (NCT01837862) evaluate safety of mebendazole combination with bevacizumab irinotecan children young adults HGG. Objective To determine maximally tolerated dose when given HGG; describe progression‐free survival (PFS)...
A 6-week-old boy presented with fever, pallor, and hepatomegaly. Ultrasound showed a huge midline abdominal mass. β-human chorionic gonadotropin was markedly elevated, suggesting diagnosis of infantile choriocarcinoma the liver. biopsy confirmed diagnosis. The patient received 6 cycles bleomycin, cisplatin, etoposide significant decrease in tumor size. However, remained unresectable. donor liver became available, infant underwent successful transplantation. He 2 posttransplant moderate dose...
Human herpesvirus 6 is highly prevalent and maintains chronic infection in immunocompetent individuals, with the potential to replicate widely settings of immunosuppression, leading clinical disease. Antiviral compounds may be ineffective and/or pose dose-limiting toxicity, therefore, immune-based therapies have garnered increased interest recent years. Attempts at addressing this unmet medical need begin understanding cellular response HHV-6 individual population levels. The present study...
Abstract Background Survival for patients with high‐risk neuroblastoma (HRNB) remains poor despite aggressive multimodal therapies. Aims To study the feasibility and safety of incorporating a genomic‐based targeted agent to induction therapy HRNB as well adding difluoromethylornithine (DFMO) anti‐GD2 immunotherapy. Methods Twenty newly diagnosed were treated on this multicenter pilot trial. Molecular tumor boards selected one six agents based tumor‐normal whole exome sequencing...
We sought to determine whether donor-derived human herpesvirus (HHV) 6B-specific CD4+ T-cell abundance is correlated with HHV-6B detection after allogeneic hematopoietic cell transplantation. identified 33 patients who received HLA-matched, non-T-cell-depleted, myeloablative transplantation and underwent weekly plasma polymerase chain reaction testing for 100 days thereafter. tested donor peripheral blood mononuclear cells HHV-6B-specific T cells. Patients above the median peak viral load...
Summary Pediatric brain and spinal cancer are the leading disease-related cause of death in children, thus we urgently need curative therapeutic strategies for these tumors. To accelerate such discoveries, Children’s Brain Tumor Network Pacific Neuro-Oncology Consortium created a systematic process tumor biobanking, model generation, sequencing with immediate access to harmonized data. We leverage data create OpenPBTA, an open collaborative project which establishes over 40 scalable analysis...
Abstract Introduction: Current treatment options for AML patients who are older or unfit intensive chemotherapy limited and associated with less than ideal outcomes, even newly approved regimens of venetoclax plus low-dose cytarabine DNA hypomethylating agents. CPX-351, a dual-drug liposomal encapsulation daunorubicin at synergistic ratio, was by the US FDA in 2017 EMA 2018 adults diagnosed therapy-related myelodysplasia-related changes. The objective this study to assess cytotoxic effects...
ABSTRACT mRNA vaccines were the first to be authorized for use against SARS-CoV-2 and have since demonstrated high efficacy serious illness death. However, limitations in these been recognized due their requirement cold storage, short durability of protection, lack access low-resource regions. We developed an easily-manufactured, potent self-amplifying RNA (saRNA) vaccine that is stable at room temperature. This saRNA formulated with a nanostructured lipid carrier (NLC), providing enhanced...
Abstract Advances in RNA and DNA profiling have identified four core molecular subgroups of medulloblastoma prognostic significance: Sonic Hedgehog (SHH) subtype, WNT Group 3, 4. Infants young children with SHH demonstrated a favorable outcome clinical trials utilizing either high-dose chemotherapy (“Head Start”) or combination intravenous intraventricular methotrexate (HIT-SKK). Two recently conducted (COG ACNS1221 St. Jude – SJYC07) failed to demonstrate similar survival advantage...