A5049258262- Glioma Diagnosis and Treatment
- Plant Physiology and Cultivation Studies
- Postharvest Quality and Shelf Life Management
- Cancer Genomics and Diagnostics
- Ruminant Nutrition and Digestive Physiology
- Neuroblastoma Research and Treatments
- Cytokine Signaling Pathways and Interactions
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Plant Surface Properties and Treatments
- Insect-Plant Interactions and Control
- Pancreatic and Hepatic Oncology Research
- Horticultural and Viticultural Research
- Epigenetics and DNA Methylation
- Medical Imaging Techniques and Applications
- Turfgrass Adaptation and Management
- Microbial Community Ecology and Physiology
- Microbial bioremediation and biosurfactants
- Berry genetics and cultivation research
- Health and Medical Research Impacts
- Plant Micronutrient Interactions and Effects
- Oil Spill Detection and Mitigation
- Soil and Water Nutrient Dynamics
- Chronic Myeloid Leukemia Treatments
- Radiomics and Machine Learning in Medical Imaging
- Crop Yield and Soil Fertility
Children's Hospital of Philadelphia
2017-2025
Auburn University
2022
Bedford Institute of Oceanography
2017-2021
Fisheries and Oceans Canada
2017-2021
Creative Commons
2021
Associated Press
2021
Pancreatic Cancer Action Network
2020
Broad Institute
2020
University of Virginia
2014-2019
Teva Pharmaceuticals (United States)
2015
We report a comprehensive proteogenomics analysis, including whole-genome sequencing, RNA and proteomics phosphoproteomics profiling, of 218 tumors across 7 histological types childhood brain cancer: low-grade glioma (n = 93), ependymoma (32), high-grade (25), medulloblastoma (22), ganglioglioma (18), craniopharyngioma (16), atypical teratoid rhabdoid tumor (12). Proteomics data identify common biological themes that span boundaries, suggesting treatments used for one type may be applied...
Molybdenum and Cu concentrations Cu/Mo ratios were determined on samples of legume hay, grass sedge oat forage, corn silage grains throughout British Columbia. In addition, the relationships between distribution both Mo concentration ratio for all feeds. The critical was selected as 2.0, with below 2.0 would be expected to cause conditioned copper deficiency. Sedge hays had a mean 2.1, which less than half 4.4 hays. other classes feed 5.0 or higher. Notwithstanding favorable ratios, 19% 2.0....
Pediatric brain tumors are the leading cause of cancer-related death in children United States and contribute a disproportionate number potential years life lost compared to adult cancers. Moreover, survivors frequently suffer long-term side effects, including secondary The Children's Brain Tumor Network (CBTN) is multi-institutional international clinical research consortium created advance therapeutic development through collection rapid distribution biospecimens data via open-science...
Pediatric brain and spinal cancers are collectively the leading disease-related cause of death in children; thus, we urgently need curative therapeutic strategies for these tumors. To accelerate such discoveries, Children's Brain Tumor Network (CBTN) Pacific Neuro-Oncology Consortium (PNOC) created a systematic process tumor biobanking, model generation, sequencing with immediate access to harmonized data. We leverage data establish OpenPBTA, an open collaborative project over 40 scalable...
Animal courtship signals include many highly conspicuous traits and behaviors, it is generally assumed that such must balance the benefits of attracting mates against some fitness costs. However, few studies have assessed multiple costs potentially incurred by any one signal, so we limited understanding relative importance different This study provides first comprehensive assessment signal for Photinus fireflies (Coleoptera: Lampyridae), using controlled experiments to measure both energy...
Accumulating evidence suggests that autoreactive plasma cells play an important role in systemic lupus erythematosus (SLE). In addition, several proinflammatory cytokines promote B cell maturation and autoantibody production. Hence, therapeutic targeting of such cytokine pathways using a selective JAK2 inhibitor, CEP-33779 (JAK2 enzyme IC(50) = 1.3 nM; JAK3 IC(50)/JAK2 65-fold), was tested two mouse models SLE. Age-matched, MRL/lpr or BWF1 mice with established SLE nephritis, respectively,...
Members of the JAK family nonreceptor tyrosine kinases play a critical role in growth and progression many cancers inflammatory diseases. JAK2 has emerged as leading therapeutic target for oncology, providing rationale development selective inhibitor. A program to optimize inhibitors combat cancer while reducing risk immune suppression associated with JAK3 inhibition was undertaken. The structure–activity relationships biological evaluation novel series compounds based on...
Abstract The contribution of rare pathogenic/likely pathogenic (P/LP) germline variants to pediatric central nervous system (CNS) tumor development remains understudied. Here, we characterized the prevalence and clinical significance P/LP in cancer predisposition genes across 830 CNS patients from Pediatric Brain Tumor Atlas (PBTA). We identified 24.2% (201/830) majority (154/201) lacked reporting genetic syndromes. Among carriers, 30.7% had putative somatic second hits or loss function...
Western Canada produces large amounts of bitumen, a heavy, highly weathered crude oil. Douglas Channel and Hecate Strait on the coast British Columbia are two water bodies that may be impacted by proposed pipeline marine shipping route for diluted bitumen (dilbit). This study investigated potential microbial communities from these waters to mitigate impacts dilbit spill. Microcosm experiments were set up with samples representing different seasons, years, sampling stations, blends. While...
Abstract Background In 2019, the Open Pediatric Brain Tumor Atlas (OpenPBTA) was created as a global, collaborative open-science initiative to genomically characterize 1,074 pediatric brain tumors and 22 patient-derived cell lines. Here, we present an extension of OpenPBTA called Cancer (OpenPedCan) Project, harmonized open-source multi-omic dataset from 6,112 cancer patients with 7,096 tumor events across more than 100 histologies. Combined RNA-Seq Genotype-Tissue Expression (GTEx) The...
Abstract Normal fruits of ‘Anjou’ pear and with cork spot (pit) symptoms collected at harvest time from trees various ages, were peeled, cored, halved the calyx ends analyzed for mineral nutrient concentration. Pitted significantly lower in Ca concentration, but there no differences Mg, K, Zn, Fe, Mn or Cu. had a mean 219 ppm (dry-weight basis) range 187 to 255 ppm. 319 244 453
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFlame Photometric Determination of Potassium in Unashed Plant Leaves.J. L. MasonCite this: Anal. Chem. 1963, 35, 7, 874–875Publication Date (Print):June 1, 1963Publication History Published online1 May 2002Published inissue 1 June 1963https://pubs.acs.org/doi/10.1021/ac60200a032https://doi.org/10.1021/ac60200a032research-articleACS PublicationsRequest reuse permissionsArticle Views155Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are...
A 15-day-old, 6.08 kg, lamb was injected subcutaneously with tilmicosin 15 mg/kg body weight. Approximately min later, the died. During necropsy, heart found to have multiple ventricular septal defects. Death attributed sudden failure due cardiac effects of in a having congenital
Diluted bitumens are produced by adding lower viscosity diluent to highly viscous bitumen enable it flow through pipelines and thus may behave differently than conventional oils when spilled into coastal seawater. Simulated surface spills using three different diluted products were carried out in May, July November water column hydrocarbons monitored over a 14 day period. Volatile total petroleum varied the depending on season type of diluent. In summer, with synthetic crude or mixture...
Samples of legume hay, grass corn silage, oat forage and grains grown throughout British Columbia were analyzed to determine Cu, Zn, Mn Fe concentrations these compared with the Agricultural Research Council minimum requirements for cattle. Approximately 95% all feeds below 10 ppm recommended These data provide first indication a general simple copper deficiency in Columbia, whereas previous reports Canada concerned pockets resulting from molybdenum toxicity. Some samples level 50 Zn....
Abstract Fruits of ‘Spartan’ apple were dipped in solutions commercial CaCl 2 after harvest to increase their Ca concentration. stored until the following June, then flesh was analyzed for Ca. Undipped fruit contained 203 ppm and 4% (wt/vol) 278 Ca, dry weight basis. When surfactants added solution, concentration 230 250 ppm. thickeners added, 373 825 These results indicate that reduce uptake by from dips but thickners with it
Abstract Patients with non-small cell lung cancer (NSCLC) who have distant metastases a poor prognosis. To determine which genomic factors of the primary tumor are associated metastasis, we analyzed data from 759 patients originally diagnosed stage I–III NSCLC as part AACR Project GENIE Biopharma Collaborative consortium. We found that TP53 mutations were significantly development new metastases. also more prevalent in history smoking, suggesting these may be at increased risk for...
Abstract Procedures used to increase the calcium content of plants, especially economic parts, are reviewed. The procedures include sprays, both dilute and concentrate, dips in solutions, with surfactants, thickeners surfactants thickeners. most effective practical procedure at present for apples is a dip 3 4 percent chloride solution, 0.25 Keltrol thickener some surfactant. This can fruit flesh concentration by 150 200 ppm. Concentrations as high 2800 ppm have been achieved but extensive...