R. David Simpson

ORCID: 0000-0002-8206-9743
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About
Contact & Profiles
Research Areas
  • Economic and Environmental Valuation
  • Conservation, Biodiversity, and Resource Management
  • Environmental Conservation and Management
  • Land Use and Ecosystem Services
  • Forest Management and Policy
  • Climate Change Policy and Economics
  • Sustainable Development and Environmental Policy
  • Renin-Angiotensin System Studies
  • Merger and Competition Analysis
  • Hormonal Regulation and Hypertension
  • Receptor Mechanisms and Signaling
  • Global trade and economics
  • Ecology and Vegetation Dynamics Studies
  • Plant and animal studies
  • Semiconductor Lasers and Optical Devices
  • Genetically Modified Organisms Research
  • Coordination Chemistry and Organometallics
  • Mining Techniques and Economics
  • Agricultural pest management studies
  • Fluorine in Organic Chemistry
  • X-ray Diffraction in Crystallography
  • Law, Economics, and Judicial Systems
  • Advanced Fiber Optic Sensors
  • Insect Resistance and Genetics
  • Crystallization and Solubility Studies

American University
2023

National Center for Environmental Assessment (EPA)
2007-2018

Environmental Protection Agency
1999-2018

Government of the United States of America
1999-2018

University of California, Berkeley
1992-2007

Durham University
2007

US Forest Service
2006

United States Department of Agriculture
2006

Monsanto (United States)
2004-2005

Resources For The Future
1991-2005

"Biodiversity prospecting" has been touted as a mechanism for both discovering new pharmaceutical products and saving endangered ecosystems. It is unclear what values may arise from such activities, however. Evidence transactions incomplete existing theoretical models are flawed. We calculate an upper bound on the value of "marginal species." Even under favorable assumptions this modest. Slightly modified lead to drastically lower estimates. extend our findings marginal hectare habitat find...

10.1086/262021 article EN Journal of Political Economy 1996-02-01

<i>International donors invest billions of dollars to conserve ecosystems in low-income nations. The most common investments aim encourage commercial activities, such as ecotourism, that indirectly generate ecosystem protection a joint product. We demonstrate paying for directly can be far more cost-effective. Although direct-payment initiatives have imposing institutional requirements, we argue all conservation face similar challenges. Thus practitioners would well advised implement the...

10.2307/3146894 article EN Land Economics 2002-08-01

Conventional wisdom has it that a country enacts strict environmental regulations will place its firms at competitive disadvantage. This view been challenged recently. Some commentators argue stricter regulation enhance domestic competitiveness: induce innovation. We evaluate this argument in strategic trade model. In very special cases strengthening of may result shift profits from foreign to firms. is not general result, however. Environmental should, course, be imposed control...

10.1006/jeem.1996.0019 article EN cc-by-nc-nd Journal of Environmental Economics and Management 1996-05-01

A multistep scalable synthesis of the clinically important hepatitis C virus (HCV) protease inhibitor BILN 2061 (1) is described. The highly convergent and consists two amide bond formations, one etherification, ring-closing metathesis (RCM) step, using readily available building blocks 2-5. optimization each step described at length. main focus paper study RCM description problems faced when scaling up to pilot scale this powerful but very challenging synthetic operation. Eventually,...

10.1021/jo060285j article EN The Journal of Organic Chemistry 2006-08-17

10.1007/bf00691819 article EN Environmental and Resource Economics 1995-12-01

ABSTRACT A number of international conservation donors support efforts to encourage indirectly by subsidizing commercial activities. Such plans beg two questions. First, if ventures are expected be profitable, why is external financing necessary for their initiation? Second, not could greater incentives generated making direct payments? We examine these questions in detail. While we find that the practical impediments instituting a payment programme may substantial, any effective...

10.1017/s1355770x00000607 article EN Environment and Development Economics 1996-05-01

Abstract The United States has not ratified the Kyoto Protocol, restricting ability of forests from participating internationally as greenhouse gas (GHG) emission offset projects. As a result, proliferation different registry and program rules is occurring in States, providing an opportunity for US forestry community to mitigate GHG emissions. This article addresses Protocol principles additionality, permanence, leakage, challenges way that these are being used qualify forest projects...

10.1093/jof/105.6.314 article EN Journal of Forestry 2007-09-01

Structure guided optimization of a series nonpeptidic alkyl amine renin inhibitors allowed the rational incorporation additional polar functionality. Replacement cyclohexylmethyl group occupying S1 pocket with (R)-(tetrahydropyran-3-yl)methyl and utilization different attachment point led to identification clinical candidate 9. This compound demonstrated excellent selectivity over related unrelated off-targets, >15% oral bioavailability in three species, efficacy double transgenic rat model...

10.1021/ml200137x article EN ACS Medicinal Chemistry Letters 2011-08-09

10.1023/a:1019836910018 article EN Environmental and Resource Economics 2002-01-01

The Boehringer-Ingelheim phosphinoimidazoline (BIPI) ligands were applied to the formation of chiral quaternary centers in asymmetric Heck reaction. Several different substrates examined detail, using more than 70 members this new ligand class. Hammett relationships determined through systematic variation electronics. All showed essentially same behavior, where enantioselectivity increased as made electron-deficient. Ligand optimization has led catalysts which give highest...

10.1021/jo049448z article EN The Journal of Organic Chemistry 2004-07-10

The authors investigate the effects of knowledge spillovers, numbers incumbents, and demand characteristics on market equilibria involving either noncooperative firms or a research joint venture. Firms engage in cost-reducing R&D before competing outputs. Noncooperative expenditure is socially suboptimal with convex likely to be so under general functions. A venture all industry always invests too little relative social optimum. It may, however, lead better performance than achieved regime....

10.2307/2950590 article EN Journal of Industrial Economics 1994-03-01

The synthesis, characterization, chemical vapor deposition, and mechanistic investigation of the thermal decomposition in aromatic solvents cis-bis(η2,η1-pent-4-en-1-yl)platinum (1) are described. Complex 1 has a unique chelated structure, giving rise to enhanced volatility, proved useful for deposition thin platinum films under mild conditions. Films deposited on glass slide hot walled tube at 175 °C have an elemental composition 82% Pt 18% C. Kinetic, deuterium labeling, trapping...

10.1021/ja9526527 article EN Journal of the American Chemical Society 1996-01-01

When the laboratory methods employed are qualitative, statistical methodologies used in testing for adventitious presence (AP) of transgenic material conventional seed and grain lots well defined. However, when response from method by is quantitative (e.g. percent DNA), developed qualitative not fully appropriate. In this paper, we present details procedures specific to methods. particular consider: (1) assessment errors using linear modelling; (2) process deciding whether or a lot meets...

10.1079/ssr2005210 article EN Seed Science Research 2005-09-01

10.1023/a:1011170024649 article EN Environmental and Resource Economics 2001-01-01

Extremely fast and at low temperatures, alkoxido complex 1 reacts with CS2 to the corresponding Re–O insertion product by direct attack of electrophile on O atom ligand. In contrast, reaction aryloxido 2 requires higher temperatures (100 °C) seven days' time; here loss a phosphine ligand probably constitutes first step. The importance such studies in design catalyst systems is obvious.

10.1002/anie.199202201 article EN Angewandte Chemie International Edition 1992-02-01

Many hope that the ecosystem services framework will provide a new and generous source of conservation funding. Heather Tallis Peter Kareiva (2005) write “realization market worth has potential to increase funding by orders magnitude”. This enthusiasm sparked an impressive volume work within service (Turner Daily, 2008). Fisher co-authors (2009) document exponential in number published papers employing terms “ecosystem services” or “ecological services”, beginning from essentially...

10.4324/9780203847602-10 article EN 2010-07-13
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