A5037230443- Smoking Behavior and Cessation
- Nicotinic Acetylcholine Receptors Study
- Synthesis and Biological Evaluation
- Advanced Chemical Sensor Technologies
- Lung Cancer Treatments and Mutations
- Obesity, Physical Activity, Diet
- Indoor Air Quality and Microbial Exposure
- Meat and Animal Product Quality
- Crystallization and Solubility Studies
- Analytical Chemistry and Chromatography
- Multicomponent Synthesis of Heterocycles
- Neuroblastoma Research and Treatments
- Cancer therapeutics and mechanisms
- X-ray Diffraction in Crystallography
- Mycotoxins in Agriculture and Food
- Genomics, phytochemicals, and oxidative stress
- Lymphoma Diagnosis and Treatment
- Synthesis of heterocyclic compounds
- Reproductive System and Pregnancy
- Growth Hormone and Insulin-like Growth Factors
- Alcohol Consumption and Health Effects
- Enzyme function and inhibition
- Influenza Virus Research Studies
- Chronic Myeloid Leukemia Treatments
- HER2/EGFR in Cancer Research
Centers for Disease Control and Prevention
2013-2020
National Center for Environmental Health
2013-2020
Teva Pharmaceuticals (United States)
2015-2016
Johnson & Johnson (United States)
2005-2009
Introduction:Electronic cigarette (e-cigarette) use is increasing dramatically in developed countries, but little known about these rapidly evolving products. This study analyzed and evaluated the chemical composition including nicotine, tobacco alkaloids, pH, flavors 36 e-liquids brands from 4 manufacturers.
This publication reports the first known use of gas chromatography-tandem mass spectrometry for quantitation five minor tobacco alkaloids (nornicotine, myosmine, anabasine, anatabine, and isonicoteine) in various samples. A summary concentrations these alkaloid levels filler from 50 popular cigarette brands were found to be 659-986 μg/g nornicotine, 8.64-17.3 127-185 927-1390 23.4-45.5 isonicoteine. Levels reference cigarettes (1R5F, 2R4F, 3R4F, CM4, CM6) as well burley, flue-cured,...
Analogues structurally related to anaplastic lymphoma kinase (ALK) inhibitor 1 were optimized for metabolic stability. The results from this endeavor not only led improved stability, pharmacokinetic parameters, and in vitro activity against clinically derived resistance mutations but also the incorporation of focal adhesion (FAK). FAK activation, via amplification and/or overexpression, is characteristic multiple invasive solid tumors metastasis. discovery clinical stage, dual FAK/ALK 27b,...
To provide researchers an extensive characterization of the SPECTRUM variable nicotine research cigarettes.Data on cigarette physical properties, content, harmful and potentially constituents in tobacco filler was compiled.Data concentrations menthol, minor alkaloids, tobacco-specific nitrosamines, polycyclic aromatic hydrocarbons, ammonia, toxic metals for all available varieties Spectrum cigarettes are provided. The similarity chemistry properties to commercial renders them acceptable use...
Introduction:In 2011 menthol cigarettes accounted for 32 percent of the market in United States, but there are few literature reports that provide measured data commercial cigarettes. To assess current application levels US cigarette market, labeled or not to contain was determined a variety contemporary domestic products.
Most electronic cigarettes (e-cigarettes) contain a solution of propylene glycol/glycerin and nicotine, as well flavors. E-cigarettes their associated e-liquids are available in numerous flavor varieties. A subset the varieties include coffee, tea, chocolate, energy drink, which, beverage form, commonly recognized sources caffeine. Recently, some manufacturers have begun marketing e-liquid products enhancers that caffeine an additive. Gas Chromatography-Mass Spectrometry (GC-MS) method for...
Snus is an oral tobacco product that originated in Sweden. products are available as fine-cut loose or pre-portioned porous "pouches." Some snus undergo pasteurization during manufacturing, a process removes reduces nitrite-forming microbes, resulting less tobacco-specific nitrosamine content the product. companies and researchers have suggested potentially harmful than traditional thus potential smoking cessation aid alternative to continued cigarette consumption. Although various...
A novel 2,7-disubstituted-pyrrolo[2,1-f][1,2,4]triazine scaffold has been designed as a new kinase inhibitor platform mimicking the bioactive conformation of well-known diaminopyrimidine motif. The design, synthesis, and validation this pyrrolo[2,1-f][1,2,4]triazine will be described for inhibitors anaplastic lymphoma (ALK). Importantly, incorporation appropriate potency selectivity determinants led to discovery several advanced leads that were orally efficacious in animal models large cell...
Anaplastic lymphoma kinase (ALK) is a promising therapeutic target for the treatment of cancer, supported by considerable favorable preclinical and clinical activities over past several years culminating in recent FDA approval ALK inhibitor crizotinib. Through series targeted modifications on an diaminopyrimidine scaffold, our research group has driven improvements potency, selectivity, overall pharmaceutical properties. Optimization this scaffold led to identification potent efficacious...
Most research on unburned tobacco has focused the harmful chemicals associated with itself. However, certain flavor additives in products can pose additional health risks. Flavors like camphor, coumarin, pulegone, eugenol, methyl salicylate, menthol and diphenyl ether have exhibited biological activity and/or toxicity both lab animals humans. This publication presents a new GC/MS method for quantitation of ten compounds (eucalyptol, menthol, ethyl cinnamaldehyde, coumarin) variety products,...
The spread of intra-abdominal cancers is a vexing clinical problem for which there no widely effective treatment. We discovered previously that (2E)-3-[(4-tert-butylphenyl)sulfonyl]acrylonitrile (1) induced cancer cell apoptosis during adhesion to normal mesothelial cells line the peritoneum. recently demonstrated sulfonylacrylonitrile portion 1 and hydrophobic aryl substitution were essential pro-apoptotic activity in cells. Here we synthesized diverse series analogues order improve...
We examined differences between nicotine concentrations and pH in cigarette cigar tobacco filler.Nicotine levels for 50 75 brands were measured. Non-mentholated mentholated products included the analysis along with several types as identified by manufacturer: large cigars, pipe cigarillos, mini little cigars.There significant found products. Mean cigarettes (19.2 mg/g) cigars (15.4 higher than other types, especially (8.79 mg/g). The mean was 5.46. Large had highest value (pH 6.10) lowest...
A new tobacco filler Standard Reference Material (SRM) has been issued by the National Institute of Standards and Technology (NIST) in September 2016 with certified reference mass fraction values for nicotine, N-nitrosonornicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, volatiles. The constituents have determined multiple analytical methods measurements at NIST Centers Disease Control Prevention, confirmatory commercial laboratories. This effort highlights development first SRM...
Abstract An efficient synthesis of the 4,4‐disubstituted piperidine scaffold 1 was accomplished by treating PMC N‐protected α,β‐unsaturated ethyl cyanoacetate 9 with various Grignard reagents (R1MgX). Subsequent heating at 190°C in a strong base provided carboxylic acids 12–20b good yield. The group easily removed room temperature 33% HBr acetic acid.
Abstract For see ChemInform in Full Text.