Salma Al‐Karmi
A5039839388- Chromatin Remodeling and Cancer
- Glioma Diagnosis and Treatment
- Click Chemistry and Applications
- Monoclonal and Polyclonal Antibodies Research
- Cancer Mechanisms and Therapy
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Radiopharmaceutical Chemistry and Applications
- Microbial Natural Products and Biosynthesis
- Neuroblastoma Research and Treatments
- Cancer-related molecular mechanisms research
- Infrared Thermography in Medicine
- Analytical Chemistry and Sensors
- Fetal and Pediatric Neurological Disorders
- Photoacoustic and Ultrasonic Imaging
- Chemical synthesis and alkaloids
- Ultrasound and Hyperthermia Applications
- Nitric Oxide and Endothelin Effects
- Gestational Trophoblastic Disease Studies
- Tumors and Oncological Cases
- Ocular Oncology and Treatments
- Photodynamic Therapy Research Studies
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Brain Metastases and Treatment
Hospital for Sick Children
2018-2021
SickKids Foundation
2018-2021
McMaster University
2015-2020
University of Toronto
2018
Centre for Probe Development and Commercialization
2015
Abstract Hydrocyanine dyes are sensitive “turn‐on” type optical probes that can detect reactive oxygen species (ROS). We have developed a method to prepare an 18 F‐labeled hydrocyanine dye as multi‐modal PET and probe. A commercially available near infrared (NIR) was modified with fluorinated prosthetic group did not alter its ROS sensing properties in the presence of superoxide hydroxyl radicals. The analogue produced using single‐step terminal fluorination procedure. Positron emission...
Abstract The fungal secondary metabolite aspergillomarasmine A (AMA) has recently been identified as an inhibitor of metallo‐β‐lactamases NDM‐1 and VIM‐2. Described herein is efficient practical route to AMA its related compounds by a sulfamidate approach. In addition, series derivatives prepared tested for biological activity in effort explore preliminary structure relationships. While it was determined that natural LLL isomer remains the most effective inactivator enzyme both vitro cells,...
A convenient method to prepare radioiodinated tetrazines was developed, such that a bioorthogonal inverse electron demand Diels–Alder reaction can be used label biomolecules with iodine-125 for in vitro screening and vivo biodistribution studies. The tetrazine prepared by employing high-yielding oxidative halo destannylation concomitantly oxidized the dihydrotetrazine precursor. product reacts quickly efficiently trans-cyclooctene derivatives. Utility demonstrated through antibody hormone...
A convenient strategy to radiolabel a hydrazinonicotonic acid (HYNIC)-derived tetrazine with 99mTc was developed, and its utility for creating probes image bone metabolism bacterial infection using both active pretargeting strategies demonstrated. The 99mTc-labelled HYNIC-tetrazine synthesized in 75% yield exhibited high stability vitro vivo. trans-cyclooctene (TCO)-labelled bisphosphonate (TCO-BP) that binds regions of calcium used evaluate the labelled bioorthogonal chemistry. approach,...
Abstract The fungal secondary metabolite aspergillomarasmine A (AMA) has recently been identified as an inhibitor of metallo‐β‐lactamases NDM‐1 and VIM‐2. Described herein is efficient practical route to AMA its related compounds by a sulfamidate approach. In addition, series derivatives prepared tested for biological activity in effort explore preliminary structure relationships. While it was determined that natural LLL isomer remains the most effective inactivator enzyme both vitro cells,...
A new photoacoustic (PA) dye was developed as a simple-to-use reagent for creating targeted PA imaging agents. The lead molecule prepared via an efficient two-step synthesis from inexpensive commercially available starting material. With the dye's innate albumin-binding properties, resulting tetrazine-derived is capable of localizing to tumor and exhibits biological half-life few hours, allowing optimized distribution profile. presence tetrazine in turn makes it possible link optoacoustic...
Background ETMRs are a newly recognized rare paediatric brain tumor with alterations of the C19MC microRNA locus. Due to varied diagnostic practices and limited clinical data, disease features determinants outcome poorly defined. We performed an integrated clinico-pathologic molecular analyses 159 primary define phenotypes, identify predictors survival critical treatment modalities for this orphan disease. Methods Primary ETMR patients were identified from Rare Brain Tumor Consortium...
Rhabdoid Tumors (RTs) are rare heritable cancers with bi-allelic SMARCB1/A4 alterations, arising in the brain (Atypical Teratoid/Rhabdoid Tumors/ATRTs) and various extra-cranial locations (Malignant Tumors/MRTs). Recent studies uncovered molecular sub-types of ATRTs MRTs, however, relationship clinico-pathologic implications MRTs remain unclear. To inform clinical understanding 450/850K methylation array profiles generated from 202 57 were used to define categories ATRTs/MRTs examine their...
Abstract ETMR, an aggressive disease characterised by C19MC alterations, were previously categorised as various histologic diagnoses. The clinical spectrum and impact of conventional multi-modal therapy on this new WHO diagnostic category remains poorly understood a majority ~200 cases reported to date lack molecular confirmation. We undertook comprehensive clinico-pathologic studies large molecularly confirmed cohort improve recognition treatment approaches. Amongst 623 CNS-PNETs patients...
Abstract Embryonal brain tumors (EBTs) remain the most common malignant pediatric tumors. Despite recent advances and improved understanding of molecular biology EBTs, clinical outcomes poor for rare EBTs. Previous large-scale genomic studies EBTs have shed light on distinct genomic, transcriptomic epigenomic profiles. Interestingly, these revealed prominent tumor heterogeneity that provides opportunity to develop novel treatment strategies improve patient outcomes. To examine...
Abstract 10% of all pediatric brain tumors arise in the brainstem. Amongst these gliomas are most common while other entities rare and infrequently described literature. In this study we investigated prevalence non-gliomatous 1323 embryonal tumours received at RBTC, identified 17 cases ETMRs (17/165) that presented as brainstem primaries. Previously grouped within CNS-PNETs, ETMR, is a new WHO diagnostic entity, characterized by C19MC alterations. ETMR disease infancy, clinical spectrum...