A5067266894- Health Systems, Economic Evaluations, Quality of Life
- Healthcare cost, quality, practices
- Diabetes Management and Research
- Pharmaceutical Economics and Policy
- Pharmaceutical studies and practices
- Asthma and respiratory diseases
- Diabetes Treatment and Management
- Diabetes and associated disorders
- Multiple Sclerosis Research Studies
- Pancreatic function and diabetes
- Inhalation and Respiratory Drug Delivery
- Polyomavirus and related diseases
- CAR-T cell therapy research
- Economic and Financial Impacts of Cancer
- Statistical Methods in Clinical Trials
- Healthcare Policy and Management
- Health disparities and outcomes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Antimicrobial Resistance in Staphylococcus
- Prenatal Screening and Diagnostics
- Diabetes Management and Education
- Medication Adherence and Compliance
- Acute Lymphoblastic Leukemia research
- Syphilis Diagnosis and Treatment
- Respiratory and Cough-Related Research
University of Montana
2016-2025
University of Colorado Anschutz Medical Campus
2016-2025
The Medical Center of Aurora
2024
Swedish Medical Center
2022
University of Rochester Medical Center
2022
University of Colorado Denver
2011-2022
Colorado School of Public Health
2021
Johns Hopkins University
2019
Observational & Pragmatic Research Institute
2016
University of Colorado Boulder
2014-2015
Among children and young adults with relapsed or refractory B-cell acute lymphoblastic leukemia, the rate of 5-year disease-free survival is 10% to 20%. Approval tisagenlecleucel, a chimeric antigen receptor T-cell therapy, represents new potentially curative treatment option. However, tisagenlecleucel expensive, current list price $475 000 per one-time administration.
Axicabtagene ciloleucel, a chimeric antigen receptor T-cell therapy, represents new and potentially curative treatment option for B-cell lymphoma. It is expected to have long-term survival benefits; however, data are limited.
Long-acting lipoglycopeptides (laLGPs) are FDA approved only for acute bacterial skin and structure infections (ABSSSIs). However, these antibiotics show promise off-label use, reductions in hospital length of stay (LOS) healthcare cost savings.To assess the effectiveness, safety, impact on LOS estimated savings from laLGP treatment Gram-positive infections.Retrospective cohort adult patients who received at least one dose laLGPs University Colorado Health system. Descriptive statistics were...
To assess the costs and project potential lifetime cost-effectiveness of ongoing Autoimmunity Screening for Kids (ASK) program, a large-scale, presymptomatic type 1 diabetes screening program children adolescents in metropolitan Denver region.We report resource utilization, costs, effectiveness measures from ASK compared with usual care (i.e., no screening). Additionally, we practical scenario by including utilization relevant to routine clinical practice. Finally, identifying benchmarks...
Abstract Background Injection drug use is associated with serious infections. Due to challenges medical management of addiction, relapses and additional infections are common. Persons who drugs (PWUD) more likely leave against advice before completing treatment, which could result in treatment failure. Prolonged intravenous (IV) antimicrobial therapy PWUD may be complicated by concern for IV catheter misuse, sometimes requiring prolonged hospitalization. Ideal alternatives would provide the...
ObjectivesLimitations in conventional cost-effectiveness methods have led to calls for incorporation of additional value elements assessments health technologies. However, gaps remain how may inform decision making. This study aimed prioritize from the perspective healthy individuals without a specific condition or indicated treatment United States among multistakeholder panel and compare importance perspective-specific elements.MethodsAdditional were prioritized 2 phases: (1) we identified...
Celiac disease (CD) has an estimated global prevalence of 1.4%.1 Guidelines support testing symptomatic or high-risk individuals for CD with total immunoglobulin A (IgA) (to exclude deficiency) and tissue transglutaminase autoantibodies (tTG-IgA).2 However, most cases remain undiagnosed due to unrecognizable symptoms no known family history CD.3 Since serial may be required over a child's lifetime, initial human leukocyte antigen (HLA) determination followed by tTG-IgA in those increased...
This study aims to evaluate the financial implications of implementing various payment models, including outcome-based agreements (OBAs), volume-based rebates, and guaranteed for newly approved gene therapies, exagamglogene autotemcel (exa-cel) lovotibeglogene (lovo-cel), in treatment sickle-cell disease (SCD) from perspective Colorado Medicaid. The analysis specifically examines cost standard care (SoC) severe SCD, impact different eligibility criteria based on vaso-occlusive events (VOEs),...
Study Objective To compare pharmacist and prescriber perceptions of the clinical financial outcomes pharmacy services in intensive care unit ( ICU ). Design pharmacists were invited to participate survey asked invite two colleagues complete questionnaires. Setting s with services. Methods The questionnaires designed solicit frequency, efficiency, about impact (on a 10‐point scale) including patient (eight functions), education (three administration scholarship (four functions). Basic defined...
This article is a call for increased use of real-world evidence in health technology assessment and related policy decision making. There currently disconnect between used to guide regulatory approval therapies inform therapeutic coverage reimbursement decisions. Public private payers need understand not only whether an intervention works but also it offers good value compared with licensed alternatives (not placebo) as they are the practice population controlled trial environment)....
To assess anxiety and risk perception among parents whose children screened positive for islet autoantibodies, indicating elevated type 1 diabetes (T1D).The Autoimmunity Screening Kids (ASK) study identified 319 age to 17 years at T1D via screening autoantibodies; 280 with confirmed autoantibodies their caregivers enrolled in a follow-up education monitoring program prevent diabetic ketoacidosis diagnosis. Parents completed questionnaires each visit, including 6-item version of the State...
To provide generalizable estimates of economic burden in epilepsy and nonepilepsy populations a comprehensive accounting for employment-based lost productivity associated with current US health care systems as compared other chronic diseases.We use the nationally representative data source (Medical Expenditure Panel Survey) from 1998 to 2009 create retrospective cohort people diagnosed by professional comparison no epilepsy.Health utilization direct costs all components treatment, including...
Nearly all patients with type 1 diabetes and 20-30 percent of 2 use insulin to manage glycemic control. Approximately one-quarter who report underuse because cost. In response, more than twenty states have implemented monthly caps on out-of-pocket spending, ranging from $25 $100. Using a difference-in-differences approach, this study evaluated whether state-level spending change usage among commercially insured enrollees. The included 33,134 people ages 18-64 had or used commercial insurance...
Background Venous thromboembolism ( VTE ) occurs frequently in critically ill patients without heparin prophylaxis. Although prevents , s occur despite A higher dosage may be more effective for preventing . Methods retrospective study was conducted using the Premier Incorporated Perspective Database to evaluate comparatively effects of different prophylaxis dosing strategies patient. Critically adult who were mechanically ventilated at least 1 day and had an intensive care unit ICU length...
Objective: Estimate the economic burden associated with incremental increases in number of cardiometabolic risk factors (CMRFs) US. Methods: We used nationally representative Medical Expenditure Panel Survey from 2010 to 2012 create a retrospective cohort people based on CMRFs (one, two, and three or four), comparison zero CMRFs. included abdominal obesity, elevated blood pressure, triglycerides, glucose were defined using diagnostic codes, prescribed medications, survey responses. Adjusted...
Objective: The objective was to simulate and compare clinical economic outcomes of self-monitoring blood glucose (SMBG) devices along error ranges strip price. Methods: We programmed a type 1 diabetes natural history treatment cost-effectiveness model. In phase 1, using past evidence from in silico modeling validated by the Food Drug Administration, we associated changes SMBG hemoglobin A1c (HbA1c) separately, severe hypoglycemia requiring an inpatient stay. 2, Markov cohort simulation...
<i>Objective: </i>To assess the costs and project potential lifetime cost-effectiveness of ongoing Autoimmunity Screening for Kids (ASK) Program, a large-scale pre-symptomatic type 1 diabetes screening program children adolescents in metro Denver region. <p><i>Research Design Methods</i>: We report resource utilization, costs, effectiveness measures from ASK as compared to usual care (i.e., no screening). Additionally, we practical scenario by including...