A5083670258- Antibiotics Pharmacokinetics and Efficacy
- Acute Lymphoblastic Leukemia research
- Pharmaceutical studies and practices
- Asthma and respiratory diseases
- Drug-Induced Hepatotoxicity and Protection
- Pharmacological Effects and Toxicity Studies
- Acute Myocardial Infarction Research
- Hematopoietic Stem Cell Transplantation
- Epilepsy research and treatment
- Antimicrobial Resistance in Staphylococcus
- Poisoning and overdose treatments
- Neonatal Respiratory Health Research
- Venous Thromboembolism Diagnosis and Management
- Cancer therapeutics and mechanisms
- Glutathione Transferases and Polymorphisms
- Drug-Induced Adverse Reactions
- Chronic Myeloid Leukemia Treatments
- Infective Endocarditis Diagnosis and Management
- Folate and B Vitamins Research
- Complementary and Alternative Medicine Studies
- Streptococcal Infections and Treatments
- Metabolism and Genetic Disorders
- Drug Transport and Resistance Mechanisms
- Inhalation and Respiratory Drug Delivery
- Myeloproliferative Neoplasms: Diagnosis and Treatment
Rambam Health Care Campus
2007-2023
Technion – Israel Institute of Technology
2007-2019
Rappaport Family Institute for Research in the Medical Sciences
1998-2013
Pharmacology Research Institute
2009-2013
Kaplan Medical Center
2010
Central University of Venezuela
2004
Northwestern University
2004
Northeastern Illinois University
2004
Haifa Medical Center
1992-2002
University of Münster
1992
The bark of Salix species contains several prodrugs salicylate, mainly salicin. aim this study was to investigate if during pain treatment with Salicis cortex extract platelet aggregation affected. A total 51 patients were enrolled in the study. Thirty-five suffering from acute exacerbations chronic low back received randomly and double-blind either 240 mg salicin/day (n = 19) or placebo 16). Further sixteen stable ischemic heart disease given 100 acetylsalicylate per day. Platelet studied...
Antibiotic prescription habits, cost pattern, and the prospective intervention in an Intensive Care Unit were analyzed.Methods: Data on antibiotic utilization costs collected prospectively from individual electronic charts August 2003 to January 2004, retrospectively December 2002.Results: A total of 180 107 patients surveyed 2002 2003.In 2002, Piperacillin-Tazobactam (13.8%) Imipenem/Cilastin (11.2%) most prescribed medications; while, 2003, Vancomycin (12.6%) (11.3%) prescribed,...
Background Busulfan (BU), often used in high dose for myeloablation before hematopoietic stem cell transplantation (HSCT), has been implicated certain HSCT toxicities, including the occurrence of hepatic veno-occlusive disease (HVOD). In addition to weight and age, gene polymorphisms specific members glutathione-transferase (GST) family (A1, P1, M1, T1), involved BU metabolism, may play a role wide inter-patient variability systemic concentrations. Procedure The present study integrated...
Purpose: Thiopurines are effective in attaining and maintaining remission patients with inflammatory bowel diseases (IBD). The major drawback of these drugs their serious adverse effects (SAE), highlighting the importance preemptive identification at risk. We aimed to examine whether gene polymorphisms GSTM1, GSTT1 TPMT, combined various clinical parameters, can predict thiopurine induced SAE. Methods: A retrospective cohort 176 Crohn's Disease (CD) treated thiopurines (131 6MP 45...
Tissue bioadhesives have raised interest in the last few decades as an alternative to sutures or staples wound closing applications because of various advantages. They are less time consuming, painful, and can be expensive, without compromising cosmetic outcome. Even though extensive efforts been made, ideal tissue adhesive has not developed date, mostly toxicity weak bonding strength issues. Novel comprised gelatin alginate with carbodiimide ( N ‐ethyl‐ ‐(3‐dimethylaminopropyl) [EDC])...
Methotrexate (MTX), a folate antagonist employed for treating wide range of malignancies, has an extensive interpatient variability, resulting in unpredictable toxicity. The present study evaluated the impact single gene polymorphisms (SNPs: rs1801133 and rs1801131 MTHFR gene; rs4149056 rs11045879 SLC01B1 rs2032582 rs1045642 ABCB1 transporter gene) on MTX blood levels toxicity samples from 69 patients with diffuse large-B-cell lymphoma (DLBCL) treated high dose intravenous (HD IV) MTX, > 2...
To report the occurrence of nimesulide-induced acute hepatitis confirmed by biopsy and an in vitro lymphocyte toxicity assay.A 54-year-old Arabic woman treated with nimesulide for chronic low back pain was admitted to hospital biopsy. Her liver function test results returned normal within one month after discontinuation. An assay that injury due exposure.A case secondary nimesulide, a laboratory assay, is described. Although clinically significant damage nonsteroidal antiinflammatory drugs...
Abstract An open trial was conducted to study the potential efficacy of antiepileptic agent lamotrigine in relieving sciatic pain and relationship between dosage, plasma concentration clinical response. Subsequent a 1 week washout period from previous analgesics, dose titrated on weekly basis 25 400 mg/day maintained at that for additional 4 weeks. Spontaneous pain, Short Form McGill Pain Questionnaire (SFMPQ), Straight Leg Raise (SLR) test, range motion lumbar spine (leaning foreword,...
The purpose of this study was to determine whether α-adrenergic receptor agonists have a role in alveolar fluid reabsorption, via Na,K-ATPase, the epithelium. Alveolar reabsorption increased approximately twofold with increasing concentrations norepinephrine (NE) as compared control rats. Treatment nonselective agonist, octopamine, and specific α1 phenylephrine, by 54 40%, respectively, control. α1-adrenergic antagonist, prazosin, inhibited stimulatory effects NE 30%, whereas α2-adrenergic...
The lack of pain alarm in painless myocardial infarction (MI) leads to increased morbidity and mortality, since patients do not seek medical treatment a timely manner. We aimed explore whether reduced systemic perception response experimental stimuli related personality variables characterizes MI patients.Level chest intensity was assessed by numerical scale, range from 0 (no pain) 100 (maximal pain). Heat threshold, magnitude estimation supra-threshold phasic tonic painful as well anxiety...
High dose busulfan (BU) has become a mainstay in conditioning regimens for hematopoietic stem cell transplantation (HSCT), despite its unpredictable response, narrow therapeutic index and severe toxicity. The present study provides an integration of pharmacokinetic genetic data 63 adults with acute myeloid leukemia (AML) preconditioned HSCT high oral BU, the aim defining biomarkers predictive poor BU metabolism. Keywords: Busulfan, HSCT, pharmacokinetics, pharmacogenetics, SNP, toxicity, GST, ABCB1
Thirty children suffering from different types of malignancies, neutropenic fever, and suspected staphylococcal bacteremia were evaluated for the pharmacokinetics vancomycin in steady-state conditions compared with eight proven methicillin-resistant infection. All studied population received intravenous at 40 mg/kg daily divided into four doses. The individual pharmacokinetic parameters calculated using a one-compartment model two blood samples. mean (±SD) half-time (t1/2, hours), clearance...
Pharmacokinetics (PK), pharmacodynamics and optimal dosing of vancomycin in obese children is not known. Higher trough levels may improve outcomes. This prospective study evaluated the appropriateness twice-daily regimen for adherence to guidelines, among non children.Children receiving vancomycin, (20 mg/kg BID) were included. Patients divided into 3 groups. Adequacy was defined as level ≥ 10mg/L AUC/MIC > 400. An alternative-dosing calculated based on individual PK parameters.Seventy-seven...