A5052832094- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Acute Myocardial Infarction Research
- Heart Rate Variability and Autonomic Control
- Cardiac electrophysiology and arrhythmias
- Pulmonary Hypertension Research and Treatments
- Coronary Interventions and Diagnostics
- Acute Kidney Injury Research
- Atrial Fibrillation Management and Outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- Electrolyte and hormonal disorders
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Hemoglobin structure and function
- Blood Pressure and Hypertension Studies
- Dialysis and Renal Disease Management
- Cardiovascular Disease and Adiposity
- Cardiac pacing and defibrillation studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac Arrhythmias and Treatments
- Cardiovascular and exercise physiology
- Infective Endocarditis Diagnosis and Management
- Erythropoietin and Anemia Treatment
Technion – Israel Institute of Technology
2015-2025
Rambam Health Care Campus
2015-2024
Haifa Medical Center
2022
Rappaport Family Institute for Research in the Medical Sciences
2008-2020
University of Miami
2016
University of Cincinnati
2011-2012
Omron (Japan)
2006-2012
Instituto Politécnico de Santarém
2012
Valve (United States)
2011
Institute of Cardiology
2009
Both type I and II diabetes are powerful independent risk factors for coronary artery disease (CAD), stroke, peripheral arterial disease. Atherosclerosis accounts virtually 80% of all deaths among diabetic patients. Prolonged exposure to hyperglycemia is now recognized a major factor in the pathogenesis atherosclerosis diabetes. Hyperglycemia induces large number alterations at cellular level vascular tissue that potentially accelerate atherosclerotic process. Animal human studies have...
Total GLUT4 content in skeletal muscle from individuals with type 2 diabetes is normal; however, recent studies have demonstrated that translocation of to the plasma membrane decreased response insulin stimulation. It not known whether physical exercise stimulates diabetes. Five subjects (two men, three women) and five normal control (5 men), as determined by a standard 75-g oral glucose tolerance test, were recruited determine an acute bout cycle activates muscle. Each subject had two open...
Clinical trials of vitamin E have failed to demonstrate a decrease in cardiovascular events. However, these studies did not address possible benefit subgroups with increased oxidative stress. Haptoglobin (Hp), major antioxidant protein, is determinant events patients Type 2 diabetes mellitus (DM). The Hp gene polymorphic common alleles, 1 and 2. allelic protein product provides inferior protection compared the product. We sought test hypothesis that could reduce DM individuals 2-2 genotype,...
The objective of this study was to test whether the frequent association between liver enzyme elevations and various components metabolic syndrome is associated with higher C-reactive protein (CRP) levels.Alanine aminotransferase (ALT), alkaline phosphatase (Alk-P), high-sensitivity CRP were measured in 1740 subjects. Adjusted geometric mean calculated for subjects normal elevated ALT Alk-P, adjusting age, sex, smoking, physical activity, body mass index, fasting glucose, triglycerides,...
Stress hyperglycemia in patients with acute myocardial infarction has been associated increased mortality. Most studies looked at the relationship between admission glucose (AG) and outcome; limited information is available about clinical significance of fasting (FG).We prospectively studied FG 30-day mortality 735 nondiabetic infarction. (> or =8-hour fast within 24 hours admission) AG were measured each patient. At 30 days, 9 deaths (2%) occurred normal FG, 11 (10%), 14 (13%), 31 (29%)...
Physical exercise can cause marked alterations in the structure and function of human skeletal muscle. However, little is known about specific signaling molecules pathways that enable to modulate cellular processes The mitogen-activated protein kinase (MAPK) cascade a major system by which cells transduce extracellular signals into intracellular responses. We tested hypothesis single bout activates MAPK pathway. Needle biopsies vastus lateralis muscle were taken from nine subjects at rest...
Background— In patients with heart failure, pulmonary hypertension (PH) predicts higher risk for morbidity and mortality. However, few data are available on the prognostic implications of reactive (precapillary) PH superimposed passive (postcapillary) PH. Methods Results— We performed a subgroup analysis 242 acute decompensated failure assigned to artery catheter placement in Vasodilation Management Acute Congestive Heart Failure trial. Patients were classified into 3 groups, using final...
Background Acute kidney injury ( AKI ) following primary percutaneous coronary intervention pPCI is frequently interpreted as contrast‐induced but may result from other insults. We aimed to determine the causal association of contrast material exposure and incidence p PCI using a control group propensity score–matched patients with ST‐segment–elevation myocardial infarction who were not exposed material. Methods Results studied 2025 underwent 1025 receiving fibrinolysis or no reperfusion...