A5011664838- Mitochondrial Function and Pathology
- Neurological disorders and treatments
- Cardiac Ischemia and Reperfusion
- Parkinson's Disease Mechanisms and Treatments
- Metabolism and Genetic Disorders
- Trace Elements in Health
- Neuroscience and Neuropharmacology Research
- Adipose Tissue and Metabolism
- ATP Synthase and ATPases Research
- Nerve injury and regeneration
- Cardiac electrophysiology and arrhythmias
- Eicosanoids and Hypertension Pharmacology
- Hormonal and reproductive studies
- Nuclear Receptors and Signaling
- Birth, Development, and Health
- Neurological Disorders and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Autophagy in Disease and Therapy
- Nitric Oxide and Endothelin Effects
- Inflammatory mediators and NSAID effects
- RNA Interference and Gene Delivery
- Estrogen and related hormone effects
- Heavy Metal Exposure and Toxicity
- Organ Transplantation Techniques and Outcomes
- Menopause: Health Impacts and Treatments
Instituto Nacional de Cardiologia
2007-2025
Instituto Nacional de Cardiología
2015-2024
Istituto di Farmacologia Traslazionale
2018
Universidad Nacional Autónoma de México
2018
International Center of Neurologic Restoration
1995-2009
University of Toronto
2009
We report our experience of unilateral subthalamotomy in patients with Parkinson's disease (PD). Eleven were included a pilot, open-labeled study to assess the effect lesion subthalamic nucleus (STN) minimum 12 months follow-up. The guidelines CAPIT (Core Assessment Program for Intracerebral Transplantation) followed recruitment into and follow-up assessment. Levodopa equivalents daily intake (mean 967 mg) unchanged during first all but one patient who stopped medication. sensorimotor region...
Stereotactic thermocoagulative lesions of the subthalamic nucleus (STN) have been shown to induce significant motor improvement in patients with Parkinson's disease (PD).89 PD were treated unilateral subthalamotomy. 68 available for evaluations after 12 months, 36 at 24 months and 25 months.The Unified Disease Rating Scale (UPDRS) scores improved significantly contralaterally lesion "off" "on" states throughout follow-up, except state last evaluation. Axial features signs ipsilateral...
Metallic nanoparticles (NPs) are widely used as food additives for human consumption. NPs reach the bloodstream given their small size, getting in contact with all body organs and cells. have adverse effects on respiratory intestinal tract; however, few studies focused toxic consequences of orally ingested metallic cardiovascular system. Here, two food-grade system were analyzed.
La experimentación con animales ha sido una herramienta fundamental en la historia del conocimiento científico y el desarrollo de medicina, sin embargo, algunos críticos siguen cuestionando su valor tachándola cruel e innecesaria argumentan que existen diferentes alternativas pueden utilizarse lugar. El objetivo este texto, es mostrar visión general importancia animal como ésta clave para cardiología. En primer lugar se da breve reseña histórica, sobre los hallazgos médicos científicos...
La experimentación con animales ha sido una herramienta fundamental en la historia del conocimiento científico y el desarrollo de medicina, sin embargo, algunos críticos siguen cuestionando su valor tachándola cruel e innecesaria argumentan que existen diferentes alternativas pueden utilizarse lugar. El objetivo este texto, es mostrar visión general importancia animal como ésta clave para cardiología. En primer lugar se da breve reseña histórica, sobre los hallazgos médicos científicos...
*Diverse changes have been described in mitochondria of apoptotic cells: the phospholipid content is modified, ceramide and GD3 concentrations increase, cristae structure nonresident proteins are recruited into mitochondrial membranes. In particular, Bax, a Bcl-2 family member protein, moves from cytosol to mitochondria, inducing cytochrome c release. Modifications distribution specific lipids membranes, along with well-known participation permeability transition pore triggering apoptosis,...
Cytidine-5'-diphosphocholine (CDP-choline) participates as an intermediary in the synthesis of phosphatidylcholine, essential component cellular membranes. Citicoline treatment has shown beneficial effects cerebral ischemia, but its potential to diminish reperfusion damage liver not been explored. In this work, we evaluated hepatoprotective effect citicoline and possible association with inflammatory/oxidative stress mitochondrial function because they are main features damage....
In the kidney, accumulation of heavy metals such as Cd2+ produces mitochondrial dysfunctions, i.e., uncoupling oxidative phosphorylation, inhibition electron transport through respiratory chain, and collapse transmembrane electrical gradient. This derangement may be due to fact that induces transition membrane permeability from selective nonselective via opening a pore. fact, this injury stimulation oxygen-derived radical generation, inducing stress. Several molecules have been used avoid or...
The kidneys are organs that can be severely impaired by metabolic syndrome (MS). This is characterized the association of various pathologies such as hypertension, dyslipidemia, and type-2 diabetes. Glycine, a nonessential amino acid, known to possess protective effects in kidney, decrease deterioration renal function reduction damage caused hypoxia. In rat model MS, effect glycine on cyclooxygenase (COX) pathway arachidonic acid (AA) metabolism was studied isolated perfused kidney. MS...
Ischemia-reperfusion injury of the kidney may lead to renal fibrosis through a combination several mechanisms. We recently demonstrated that fasting protects rat against oxidative stress and mitochondrial dysfunction in early acute injury, also development. Here we show preoperative preserves redox status homeostasis at chronic phase damage after severe ischemia. Also, protective effect coincides with suppression inflammation endoplasmic reticulum stress, as well down-regulation mechanistic...
Metabolic syndrome (MetS) is a cluster of factors that increase the risk developing diabetes, stroke, and heart failure. The pathophysiology injury by ischemia/reperfusion (I/R) highly complex inflammatory condition plays an important role increasing matrix remodeling cardiac apoptosis. Natriuretic peptides (NPs) are hormones with numerous beneficial effects mainly mediated cell surface receptor named atrial natriuretic peptide (ANPr). Although NPs powerful clinical markers failure, their in...
In this work we examined the effect of low concentrations Cu(2+) on opening mitochondrial non-specific pore. The purpose was addressed to further contribute knowledge mechanisms that regulate open/closed cycles permeability transition Membrane leakage established by measuring matrix Ca(2+) efflux and swelling. experimental results indicate at very promoted release accumulated Ca(2+), as well swelling, provided 1,10-phenanthroline has been added. Carboxyatractyloside exhibited additive...
In a model of hypertensive and hypertriglyceridemic rats (HTG), in which oxidative stress is increased, the influence gender upon activities catalase (CAT), glutathione peroxidase (GPX) superoxide dismutase (SOD) was investigated. Statistically significant differences between antioxidant enzyme treatment with relation to were analyzed. Weanling Wistar given normal rat chow either tap water for control group or 30% sucrose solution HTG group, 5–6 months. At end experimental period, blood...
Oophorectomy in adult rats affected cardiac mitochondrial function. Progression of alterations was assessed at one, two and three months after surgery: one month, very slight changes were observed, which increased months. Gradual effects included decrease the rates oxygen consumption respiratory uncoupling presence complex I substrates, as well compromised Ca 2+ buffering ability. Malondialdehyde concentration increased, whereas ROS-detoxifying enzyme Mn superoxide dismutase (MnSOD)...