A5086414179- Peroxisome Proliferator-Activated Receptors
- Renin-Angiotensin System Studies
- Eicosanoids and Hypertension Pharmacology
- Migration, Ethnicity, and Economy
- Migration and Labor Dynamics
- Adipose Tissue and Metabolism
- Nitric Oxide and Endothelin Effects
- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Signaling Pathways in Disease
- Intergenerational Family Dynamics and Caregiving
- Latin American and Latino Studies
- Cardiac Fibrosis and Remodeling
- Pomegranate: compositions and health benefits
- Diaspora, migration, transnational identity
- Calpain Protease Function and Regulation
- Sulfur Compounds in Biology
- Diet, Metabolism, and Disease
- Mitochondrial Function and Pathology
- Work-Family Balance Challenges
- Educational Research and Science Teaching
- Social Sciences and Policies
- Social Issues and Policies in Latin America
- Pharmacology and Obesity Treatment
- Protein Kinase Regulation and GTPase Signaling
Instituto Nacional de Cardiología
2012-2025
National University of Rosario
2022-2023
Universidad Abierta Interamericana
2022-2023
San Diego State University
2000-2016
Instituto Politécnico Nacional
2012-2015
Center for Research and Advanced Studies of the National Polytechnic Institute
2012-2015
Peroxisome proliferator-activated receptors (PPAR) play a critical physiological role in energy homeostasis, inflammation, and protective cardiovascular function. We assessed the antioxidant effect of clofibrate-induced receptor alpha (PPARα) stimulation on ischemic myocardium myocardial morphology hemodynamics. Male Wistar rats (300 g) were distributed into following groups: (1) Sham, (2) ischemia vehicle treated (MI-V), (3) clofibrate [100 mg/kg/ intraperitoneally) (MI-C). Reactive oxygen...
Under conditions of hyperglycemia and ischemia/reperfusion (I/R) injury, myocardial oxidative stress increases, leading to cellular damage. Inhibition has been reported be involved in the cardioprotective effects hydrogen sulfide (H2S) during I/R diabetes. Recent studies have shown that H2S potential protect heart. However, mechanism by which regulates level cardiac reactive oxygen species (ROS) hyperglycemic remains unclear. Therefore, objective this study was evaluate cytoprotective effect...
Myocardial oxidative stress increases under conditions of hyperglycemia and ischemia/reperfusion (I/R) injury, leading to cellular damage. Inhibition is involved in the cardioprotective effects hydrogen sulfide (H2S) during I/R diabetes, H2S has potential protect heart. However, mechanism by which regulates level cardiac reactive oxygen species (ROS) hyperglycemic remains unclear. Therefore, objective this study was evaluate cytoprotective effect primary cardiomyocyte cultures subjected...
Renin-angiotensin system (RAS) activation promotes oxidative stress which increases the risk of cardiac dysfunction in metabolic syndrome (MetS) and favors local insulin resistance. Fibrates regulate RAS improving MetS, type-2 diabetes cardiovascular diseases. We studied effect fenofibrate treatment on myocardic signaling pathway Angiotensin II (Ang II)/Angiotensin type 1 receptor (AT1) its relationship with myocardial resistance MetS rats under heart ischemia. Control were assigned to...
Numerous studies have supported a role for oxidative stress in the development of ischemic damage and endothelial dysfunction. Crataegus oxyacantha (Co) Rosmarinus officinalis (Ro) extracts are polyphenolic-rich compounds that proven to be efficient treatment cardiovascular diseases. We studied effect from Co Ro on myocardial associated with status production different vasoactive agents. Rats were assigned following groups: (a) sham; (b) vehicle-treated infarction (MI) (MI-V); (c)...
Rosiglitazone (RGZ), a peroxisome proliferator-activated receptor gamma (PPARγ) ligand, has been reported to act as insulin sensitizer and exert cardiovascular actions. In this work, we hypothesized that RGZ exerts PPARγ-dependent regulation of blood pressure through modulation angiotensin-converting enzyme (ACE)-type 2 (ACE2)/angiotensin-(1-7)/angiotensin II type-2 (AT2R) axis in an experimental model high pressure. We carried on experiments normotensive (Sham) aortic coarctation...
Since the 1970s global and national economic processes have reshaped organization of production social reproduction. As part change in reproduction, there is an increased demand for domestic workers. The focus this article on Mexican immigrant women who fulfill that form a
Mexican women are increasingly migrating north, leaving their homes and families behind looking for private domestic work in U.S. cities. The journey, fraught with danger those lacking legal entry documents, involves moving across social cultural divides as well an international political border. Women bear this dislocation not through unencumbered choice, but within a context of structural constraint. contemporary movement borders is rooted globalization processes—the economic restructuring...
Metabolic syndrome (MetS) is a cluster of factors that increase the risk developing diabetes, stroke, and heart failure. The pathophysiology injury by ischemia/reperfusion (I/R) highly complex inflammatory condition plays an important role increasing matrix remodeling cardiac apoptosis. Natriuretic peptides (NPs) are hormones with numerous beneficial effects mainly mediated cell surface receptor named atrial natriuretic peptide (ANPr). Although NPs powerful clinical markers failure, their in...
Myocardial infarction (MI) has been associated with an inflammatory response and a rise in TNF-α, interleukin (IL)-1β, IL-6. Peroxisome proliferator-activated receptors (PPARs) promote decreased expression of molecules. We aimed to study whether PPAR stimulation by clofibrate decreases inflammation reduces infarct size rats MI. Male Wistar were randomized into 3 groups: control, MI + vehicle, (100 mg/kg). Treatment was administered for consecutive days, previous 2 h induced increase protein...
Myocardial infarction (MI) initiates an inflammatory response that promotes both beneficial and deleterious effects. The early helps the myocardium to remove damaged tissue; however, a prolonged later brings cardiac remodeling characterized by functional, metabolic, structural pathological changes. Current pharmacological treatments have failed reverse ischemic-induced damage. Therefore, our aim was study if clofibrate treatment capable of decreasing inflammation apoptosis, ventricular...
Lesions caused by high glucose (HG), hypoxia/reperfusion (H/R), and the coexistence of both conditions in cardiomyocytes are linked to an overproduction reactive oxygen species (ROS), causing irreversible damage macromolecules cardiomyocyte as well its ultrastructure. Fenofibrate, a peroxisome proliferator-activated receptor alpha (PPARα) agonist, promotes beneficial activities counteracting cardiac injury. Therefore, objective this work was determine potential protective effect fenofibrate...
We have recently demonstrated that peroxisome proliferator-activated receptor alpha (PPARα) stimulation lowers the production of angiotensin II while increasing Ang-(1-7), both in cardiac and plasmatic level. This improves nitric oxide bioavailability, preserving histologic features functioning. Based on these results, we decided to study effect PPARα renin-angiotensin system components ischemic myocardium. Male Wistar rats (weighing 300-350 g) were assigned following groups: (1) sham, (2)...
Myocardial ischemia initiates a chain of pathological conditions leading to cardiomyocyte death. Therefore, pharmacological treatment stop ischemia-induced damage is necessary. Fibrates, have been reported decrease inflammatory markers and modulate the renin-angiotensin system (RAS). Our aim was explore if clofibrate treatment, administered one week after myocardial event, decreases MI-induced cardiac damage. Wistar rats were assigned to: 1. Sham or 2. Coronary artery ligation (MI). Seven...
The activation of the renin-angiotensin system (RAS) participates in development metabolic syndrome (MetS) and heart failure. PPAR-alpha by fenofibrate reverts some effects caused these pathologies. Recently, nonclassical RAS components have been implicated pathogenesis hypertension myocardial dysfunction; however, their cardiac functions are still controversial. We evaluated if signaling pathways, directed angiotensin III angiotensin-(1-7), involved cardioprotective effect during ischemia...
Objective: Rosiglitazone (RGZ), a peroxisome proliferator-activated receptor gamma (PPARγ) ligand, has been reported to function like an insulin sensitizer and exerts cardiovascular actions. The activation of PPARγ described have antiapoptotic effects in renal ischemia-reperfusion models. We hypothesized that RGZ PPARγ–dependent regulation blood pressure decreases kidney apoptosis experimental model hypertension. Design method: performed the experiments normotensive (sham) aortic coarctation...