Francisco‐Javier Roldán

ORCID: 0000-0003-4726-0048
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About
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Research Areas
  • Cardiac Valve Diseases and Treatments
  • Cardiac Structural Anomalies and Repair
  • Cardiovascular Function and Risk Factors
  • Cardiac Imaging and Diagnostics
  • Infective Endocarditis Diagnosis and Management
  • Cardiovascular and Diving-Related Complications
  • Aortic Disease and Treatment Approaches
  • Cardiac pacing and defibrillation studies
  • Atrial Fibrillation Management and Outcomes
  • Cardiomyopathy and Myosin Studies
  • Congenital Heart Disease Studies
  • Mechanical Circulatory Support Devices
  • Cardiac tumors and thrombi
  • Cardiac Arrhythmias and Treatments
  • Cardiovascular Effects of Exercise
  • Cardiac Ischemia and Reperfusion
  • Acute Myocardial Infarction Research
  • Sarcoma Diagnosis and Treatment
  • Coronary Artery Anomalies
  • Trypanosoma species research and implications
  • Ultrasound in Clinical Applications
  • Technology in Education and Healthcare
  • Business, Innovation, and Economy
  • Landslides and related hazards
  • Cardiac electrophysiology and arrhythmias

Instituto Nacional de Cardiología
2014-2025

Instituto Nacional de Cardiologia
1999-2025

Instituto Geológico y Minero de España
2016-2017

Hospital Universitario Virgen del Rocío
2015

La experimentación con animales ha sido una herramienta fundamental en la historia del conocimiento científico y el desarrollo de medicina, sin embargo, algunos críticos siguen cuestionando su valor tachándola cruel e innecesaria argumentan que existen diferentes alternativas pueden utilizarse lugar. El objetivo este texto, es mostrar visión general importancia animal como ésta clave para cardiología. En primer lugar se da breve reseña histórica, sobre los hallazgos médicos científicos...

10.31206/rmdo612025 article ES Revista Mexicana de Orientación Educativa 2025-01-01

La experimentación con animales ha sido una herramienta fundamental en la historia del conocimiento científico y el desarrollo de medicina, sin embargo, algunos críticos siguen cuestionando su valor tachándola cruel e innecesaria argumentan que existen diferentes alternativas pueden utilizarse lugar. El objetivo este texto, es mostrar visión general importancia animal como ésta clave para cardiología. En primer lugar se da breve reseña histórica, sobre los hallazgos médicos científicos...

10.31206/rmdo632025 article ES Revista Mexicana de Orientación Educativa 2025-01-01

Type 4 cardiorenal syndrome (CRS-4) is a pathology in which chronic kidney disease (CKD) triggers the development of cardiovascular disease. CKD pathophysiology produces alterations that can affect bioenergetics heart mitochondria, causing oxidative stress and reducing antioxidant glutathione (GSH) levels. GSH depletion alters protein function by affecting post-translational modifications such as S-glutathionylation (RS-SG), exacerbating stress, mitochondrial dysfunction. On other hand,...

10.3390/antiox14030367 article EN cc-by Antioxidants 2025-03-20

This narrative review aims to evaluate strategies for reducing door-to-balloon (D2B) time in ST-elevation myocardial infarction (STEMI) patients, focusing on pre-hospital, in-hospital, and technological innovations, as well addressing challenges ensure sustainability. We reviewed recent literature from 2004 onward, examining various approaches streamline STEMI care improve D2B time. The encompasses pre-hospital interventions such advanced ECG monitoring alerts, in-hospital standardized...

10.3389/fcvm.2025.1509365 article EN cc-by Frontiers in Cardiovascular Medicine 2025-03-31

In large necropsy studies dissecting intramyocardial hematoma (DIH) with serpiginous tracts across the myocardial fibers has been reported in both septum and left ventricle free wall.We studied 15 patients admitted to hospital acute infarction (AMI) which DIH was demonstrated by either transthoracic and/or transesophageal confirmed intraoperatively or necropsy.In nine hemorrhagic dissection predominantly remaining it wall of (LV). Myocardial involved ventricular inferior two, anterior 13...

10.1111/j.1540-8175.2008.00804.x article EN Echocardiography 2008-11-11

Abstract Ground subsidence in the southeastern border of Granada Basin (SE Spain) has been studied using remote sensing techniques. Over last decades, region experienced a huge urban expansion, which caused substantial increase water supply requirements. Water needs are exclusively met by groundwater means numerous pumping wells, exploit confined detrital aquifer alluvial fan deposits with heterogeneous facies distribution. A general piezometric level decline (up to 50 m) recorded during...

10.1002/hyp.10793 article EN Hydrological Processes 2016-01-23

Terrain surface displacements at a site can be induced by more than one geological process. In this work, we use advanced differential interferometry SAR (A-DInSAR) to measure ground deformation in Arcos de la Frontera (SW Spain), where severe damages related landslide activity and subsidence have occurred recent years. The are concentrated two residential neighborhoods constructed between 2001 2006. One of the neighborhoods, called La Verbena, is located head an active retrogressive that...

10.3390/rs9080787 article EN cc-by Remote Sensing 2017-07-31

10.1016/s1885-5857(06)60236-3 article EN Revista Española de Cardiología (English Edition) 2005-01-01

The incidence of kidney disease is increasing worldwide. Acute injury (AKI) can strongly favor cardio-renal syndrome (CRS) type 3 development. However, the mechanism involved in CRS development not entirely understood. In this sense, mitochondrial impairment both organs has become a central axis physiopathology. This study aimed to elucidate molecular mechanisms associated with cardiac and its role folic acid-induced AKI (FA-AKI) model. Our results showed that 48 h after FA-AKI,...

10.3390/antiox12081592 article EN cc-by Antioxidants 2023-08-10

Background Among patients with a patent foramen ovale and cryptogenic ischemic stroke, the long-term prognosis is unclear. Aims This study aims to estimate recurrence rate in young stroke without ovale. Patients methods One hundred eighty-six (aged 18–45 years) were prospectively followed for up five-years. They divided into two groups according echocardiographic presence of All received aspirin (100mg/day) secondary prevention. Results Mean age was 32·3 (standard deviation 7·9) years....

10.1111/j.1747-4949.2011.00641.x article EN International Journal of Stroke 2011-10-06

Potentially fatal cardiac rupture is a complication of myocardial infarction (MI), which can appear in the first hours acute event and during course week. The intramyocardial dissecting hematoma might as component evolution process. description myocardium helical muscular band facilitates explanation fiber dissection. With echocardiography, it possible to diagnose hematomas (IDH), determine its location, progression, potential complications, some cases reabsorption. It necessary search for...

10.1111/echo.12017 article EN Echocardiography 2012-11-20

Abstract The catabolism and structure of high‐density lipoproteins (HDL) may be the determining factor their atheroprotective properties. To better understand role kidney in HDL catabolism, here we characterized subclasses catabolic rates apo A‐I a rabbit model proteinuria. Proteinuria was induced by intravenous administration doxorubicin New Zealand white rabbits ( n = 10). size subclass lipids were assessed electrophoresis isolated lipoproteins. rate HDL‐apo evaluated exogenous...

10.1007/s11745-016-4120-6 article EN Lipids 2016-01-19

Myocardial infarction (MI) initiates an inflammatory response that promotes both beneficial and deleterious effects. The early helps the myocardium to remove damaged tissue; however, a prolonged later brings cardiac remodeling characterized by functional, metabolic, structural pathological changes. Current pharmacological treatments have failed reverse ischemic-induced damage. Therefore, our aim was study if clofibrate treatment capable of decreasing inflammation apoptosis, ventricular...

10.3390/molecules24020270 article EN cc-by Molecules 2019-01-12

Chagas disease is a chronic and potentially lethal disorder caused by the parasite Trypanosoma cruzi , an effective treatment has not been developed for disease. The objective of this study was to determine effectiveness therapeutic DNA vaccine containing T. genes in dogs with experimentally induced through clinical, pathological, immunological analyses. Infection Beagle H8 strain performed intraperitoneally 3500 metacyclic trypomastigotes/kg body weight. Two weeks after infection, plasmid...

10.1155/2020/9794575 article EN cc-by Journal of Immunology Research 2020-05-05
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