A5043979251- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Stress Responses and Cortisol
- Diet and metabolism studies
- Neuroendocrine regulation and behavior
- Adipokines, Inflammation, and Metabolic Diseases
- Gestational Diabetes Research and Management
- Tryptophan and brain disorders
- Fatty Acid Research and Health
- Obesity, Physical Activity, Diet
- Pregnancy and preeclampsia studies
- Infant Nutrition and Health
- Hormonal Regulation and Hypertension
- Pancreatic function and diabetes
- Regulation of Appetite and Obesity
- Digestive system and related health
- Gut microbiota and health
- Biochemical Analysis and Sensing Techniques
- Public Health and Environmental Issues
- Reproductive Biology and Fertility
- COVID-19 and healthcare impacts
- Liver Disease Diagnosis and Treatment
- Maternal Mental Health During Pregnancy and Postpartum
- Cardiovascular Function and Risk Factors
- Muscle Physiology and Disorders
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2016-2025
Consejo Nacional de Humanidades, Ciencias y Tecnologías
2022
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2021-2022
Nantes Université
2021-2022
Hospital Metropolitano
2022
PhysioPathologie des Adaptations Nutritionnelles
2021-2022
Instituto de Química y Fisicoquímica Biológicas
2017
Instituto Politécnico Nacional
2017
Universidad Autónoma de la Ciudad de México
2017
Zero to Three
2017
Protein restriction in pregnancy produces maternal and offspring metabolic dysfunction potentially as a result of oxidative stress. Data are lacking on the effects inhibition We hypothesized that resveratrol administration decreases stress, preventing, at least partially, low protein-induced dysfunction. In present study, pregnant wistar rats ate control (C) (20% casein) or protein-restricted (R) (10% isocaloric diet. Half each group received orally, 20 mg kg(-1) day(-1), throughout...
Key points Maternal high‐fat diet consumption predisposes to metabolic dysfunction in male and female offspring at young adulthood. obesity programs non‐alcoholic fatty liver disease (NAFLD) a sex‐dependent manner. We demonstrate transcriptome profiles rat of obese mothers. In this study, we focused on pathways related insulin, glucose lipid signalling. These results improve understanding the mechanisms by which maternal affects offspring. Abstract (MO) (F1) obesity, insulin resistance (IR)...
Abstract Maternal protein deficiencies can developmentally program offspring to lifelong dysfunction of many physiological systems. We hypothesized that maternal isocaloric low diet during fetal and early postnatal development would negatively affect female anxiety, exploration, associative learning motivation as measured by the elevated plus maze (EPM), open field test (OFT), operant conditioning progressive ratio task, respectively. Control mothers (C) received a 20% casein restricted (R)...
Abstract We studied the effects of maternal high fat diet (HFD, 25% calories from administered before and during pregnancy lactation) dietary intervention (switching dams HFD to control diet) at different periconceptional periods on male offspring anxiety related behavior, exploration, learning, motivation. From weaning postnatal day (PND) 21, female subjects produced be mothers in study received either (CTR – 5% fat), through lactation (MO), PNDs 21–90 followed by CTR (pre‐gestation (PG)...
Unique situations in female physiology require volume retention. Accordingly, a dimorphic regulation of the thiazide-sensitive Na(+)-Cl(-) cotransporter (NCC) has been reported, with higher activity females than males. However, little is known about hormones and mechanisms involved. Here, we present evidence that estrogens, progesterone, prolactin stimulate NCC expression phosphorylation. The sex difference abundance, however, species dependent. In rats, phosphorylation males, while mice...
Maternal overnutrition including pre-pregnancy, pregnancy and lactation promotes a lipotoxic insult leading to metabolic dysfunction in offspring. Diet-induced obesity models (DIO) show that changes hypothalamic mitochondria fusion fission dynamics modulate dysfunction. Using three selective diet formula High fat (HFD), Cafeteria (CAF) Sugar Diet (HSD), we hypothesized maternal diets exposure program leads male offspring which is exacerbated by second after weaning. We exposed female Wistar...
Maternal hypercaloric exposure during pregnancy and lactation is a risk factor for developing diseases associated with inflammation such as obesity, diabetes and, neurological in the offspring. Neuroinflammation might modulate neuronal activation flavonoids are dietary compounds that have been proven to exert anti-inflammatory properties. Thus, aim of present study evaluate effect maternal supplementation (kaempferol-3-O-glucoside narirutin) on prevention depression-like behaviour female...
Key points Maternal obesity predisposes to metabolic dysfunction in male and female offspring high‐fat diet consumption prior throughout pregnancy lactation accelerates ageing a sex‐dependent manner This study provides evidence for programming‐ageing interactions Abstract Human epidemiological studies show that maternal (MO) shortens life health span. Life course cellular mechanisms involved this developmental interaction are poorly understood. In well‐established rat MO model, Wistar rats...
Abstract We determine whether the offspring of obese mothers and a postnatal high-fat diet (HFD) modify protein levels related to muscle synthesis (p70S6K-alpha) or atrophy (Murf MAFbx), if administration (-)-epicatechin (Epi) can these alterations. hypothesized that ubiquitin ligases Murf MAFbx would be increased in obesogenic context, either by utero environment diet, while p70S6K-alpha kinase its activation might decreased. Eight groups six male Wistar formed eight experimental groups:...
Background/Objectives: Timbe (Acaciella angustissima) is a legume recognized for its environmental benefits, such as soil restoration, wildlife nutrition, and the presence of biologically active compounds. This study investigates antioxidant, pharmacological, antimicrobial properties Timbe. Methods: The total phenolic content, flavonoids, condensed tannins from flowers, seeds, pods were quantified, their antioxidant activity was evaluated using DPPH ABTS assays. Enzymatic activities assessed...
Abstract Before weaning, breast milk is the physiological form of neonatal nutrition, providing pups with all nutrient requirements. Maternal low-protein diet (LPD) during pregnancy and lactation induces adverse changes in key maternal organs, which have negative effects on pup development. We studied LPD liver weight, mammary gland (MG) cell differentiation, composition production development throughout lactation. fed rats control (C) or (R) At 7 d early, 14 mid 21 late stages, biochemical...
Suboptimal developmental environments program offspring to lifelong health complications including affective and cognitive disorders. Little is known about the effects of suboptimal intra-uterine on associative learning motivational behavior. We hypothesized that maternal isocaloric low protein diet during pregnancy lactation would impair motivation as measured by operant conditioning progressive ratio task, respectively. Control mothers were fed 20% casein (C) restricted (R) 10% provide...
Maternal nutritional challenges during fetal and neonatal development result in developmental programming of multiple offspring organ systems including brain maturation function. A maternal low-protein diet pregnancy lactation impairs associative learning motivation. We evaluated effects a gestation and/or on male spatial hippocampal neural structure. Control mothers (C) ate 20% casein restricted (R) 10% casein, providing four groups: CC, RR, CR, RC (first letter pregnancy, second diet). the...
Adipocyte size (AS) shows asymmetric distribution related to current metabolic state, e.g., adipogenesis or lipolysis. We profiled AS using different statistical approaches in offspring (F1) of control (C) and obese (MO) mothers (F0) with without F0 F1 exercise. Offspring from exercise were designated CF0ex MOF0ex. Exercised sedentary CF1ex MOF1ex. retroperitoneal fat cross-sectional was measured by median, cumulative distributions, data dispersion extreme values based on gamma modeling....
There is limited evidence about the inflammatory potential of diet in children. The aim this study was to evaluate association between Children’s Dietary Inflammatory Index (C-DII) from 5 11 years with adiposity and biomarkers Mexican We analyzed 726 children a birth cohort complete dietary information measurements at 5, 7 y 286 IL-6, hsCRP, leptin adiponectin y. C-DII trajectories were estimated using latent class linear mixed models. used models for logistic multinomial regression...
Abstract Obese mothers’ offspring develop obesity and metabolic alterations in adulthood. Poor postnatal dietary patterns also contribute to its comorbidities. We aimed determine whether obese an adverse environment, such as high-fat diet (HFD) consumption (second hit) exacerbates body fat accumulation, adipocyte size distribution. Female Wistar rats ate chow (C-5 %-fat) or HFD (maternal (MO)-25 from weaning until the end of lactation. Male were weaned on either control (C/C MO/C, maternal...
Maternal obesity (MO) causes maternal and fetal oxidative stress (OS) metabolic dysfunction. We investigated whether supplementing obese mothers with resveratrol improves alterations reduces OS in the placenta liver. From weaning through pregnancy female Wistar rats ate chow (C) or a high-fat diet (MO). One month before mating until 19 days' gestation (dG), half received 20 mg resveratrol/kg/d orally (Cres MOres). At 19dG, body weight, retroperitoneal fat adipocyte size, parameters,...