A5022944911- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Phytochemicals and Antioxidant Activities
- Stress Responses and Cortisol
- Natural Antidiabetic Agents Studies
- Biochemical and biochemical processes
- Liver Disease Diagnosis and Treatment
- Seed and Plant Biochemistry
- Advanced Glycation End Products research
- Genetics, Aging, and Longevity in Model Organisms
- Gestational Diabetes Research and Management
- Chronic Kidney Disease and Diabetes
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Hormonal Regulation and Hypertension
- Tryptophan and brain disorders
- Ginkgo biloba and Cashew Applications
- Effects and risks of endocrine disrupting chemicals
- Circadian rhythm and melatonin
- Sesame and Sesamin Research
- Adipokines, Inflammation, and Metabolic Diseases
- Neuroendocrine regulation and behavior
- Bee Products Chemical Analysis
- Sperm and Testicular Function
- Epigenetics and DNA Methylation
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2014-2025
Autonomous University of Queretaro
2011-2018
The University of Texas Health Science Center at San Antonio
2014
Key points Maternal high‐fat diet consumption predisposes to metabolic dysfunction in male and female offspring at young adulthood. obesity programs non‐alcoholic fatty liver disease (NAFLD) a sex‐dependent manner. We demonstrate transcriptome profiles rat of obese mothers. In this study, we focused on pathways related insulin, glucose lipid signalling. These results improve understanding the mechanisms by which maternal affects offspring. Abstract (MO) (F1) obesity, insulin resistance (IR)...
Key points Maternal obesity predisposes to metabolic dysfunction in male and female offspring high‐fat diet consumption prior throughout pregnancy lactation accelerates ageing a sex‐dependent manner This study provides evidence for programming‐ageing interactions Abstract Human epidemiological studies show that maternal (MO) shortens life health span. Life course cellular mechanisms involved this developmental interaction are poorly understood. In well‐established rat MO model, Wistar rats...
Background/Objectives: Timbe (Acaciella angustissima) is a legume recognized for its environmental benefits, such as soil restoration, wildlife nutrition, and the presence of biologically active compounds. This study investigates antioxidant, pharmacological, antimicrobial properties Timbe. Methods: The total phenolic content, flavonoids, condensed tannins from flowers, seeds, pods were quantified, their antioxidant activity was evaluated using DPPH ABTS assays. Enzymatic activities assessed...
Maternal obesity (MO) causes maternal and fetal oxidative stress (OS) metabolic dysfunction. We investigated whether supplementing obese mothers with resveratrol improves alterations reduces OS in the placenta liver. From weaning through pregnancy female Wistar rats ate chow (C) or a high-fat diet (MO). One month before mating until 19 days' gestation (dG), half received 20 mg resveratrol/kg/d orally (Cres MOres). At 19dG, body weight, retroperitoneal fat adipocyte size, parameters,...
A high-fat diet during intrauterine development predisposes offspring (F1) to phenotypic alterations, such as lipid synthesis imbalance and increased oxidative stress, causing changes in male fertility. The objective of this study was evaluate the effects maternal obesity pregnancy lactation on antioxidant enzymes F1 testes. Female Wistar rats (F0) were fed either a control (C, 5% fat) or an obesogenic (MO, obesity, 25% from weaning throughout subsequent lactation. weaned diet. Testes...
We investigated whether excessive retroperitoneal adipose tissue (AT) expansion programmed by maternal obesity (MO) affects adipocyte size distribution and gene expression in relation to proliferation differentiation male female offspring (F1) from control (F1C) obese (F1MO) mothers. Female Wistar rats (F0) ate a or high-fat diet weaning through pregnancy lactation. F1 were weaned onto euthanized at 110 postnatal days. Fat depots weighed estimate the total AT. Serum glucose, triglyceride,...
In Mexico one in 14 deaths are caused by diabetes mellitus (DM) or the macro and microvascular disorders derived from it. A continuous hyperglycemic state is characteristic of DM, resulting a sustained insulin resistance and/or dysfunction β-pancreatic cells. Acaciella angustissima little studied species showing significant antioxidant activity that can be used as treatment this disease preventive against complications. The objective study was to explore effect oral administration A....
Diet-induced obesity is associated with premature cognitive decline. Elevated consumption of fats and sugars in humans rodents has been deficits recognition memory, which modulated by the hippocampus. Alterations excitatory inhibitory neurotransmitters this area have observed after hypercaloric diets, but effects on episodic-like memory are not conclusive.To investigate diets their relationship γ-aminobutyric acid (GABA), glutamate glutamine genetic expression hippocampus.A control diet...
Diabetic nephropathy (DN) is a major complication of diabetes and caused by an imbalance in the expression certain genes that activate or inhibit vital cellular functions kidney. Despite several recent advances, pathogenesis DN remains far from clear, suggesting need to carry out studies identifying molecular aspects, such as gene expression, could play key role development DN. There are techniques analyze transcriptome living organisms. In this study, suppression subtractive hybridization...
The steroids corticosterone and dehydroepiandrosterone (DHEA) perform multiple life course functions. Rodent life-course circulating DHEA trajectories are unknown. We studied basal in offspring of rats fed protein-restricted (10% protein, R) or control (20% C), pregnancy diet first letter, and/or lactation second producing four groups-CC, RR, CR, RC. hypothesize that 1. maternal programs sexually dimorphic, steroid concentrations, 2. an aging-related will fall. Both changes differ with the...
At the molecular level, cellular ageing involves changes in multiple gene pathways. Cellular senescence is both an important initiator and a consequence of natural ageing. Senescence results mechanisms that result decrease cell cycle activity. Liver impair hepatic function. Given well-established sexual dimorphism ageing, we hypothesized process driven by sex-dependent mechanisms. We studied our well-characterized normal, chow-fed rat model, lifespan ∼850 days, which have reported...
We investigated whether maternal obesity affects the hepatic mitochondrial electron transport chain (ETC), sirtuins, and antioxidant enzymes in young (110 postnatal days (PND)) old (650PND) male female offspring a sex- age-related manner. Female Wistar rats ate control (C) or high-fat (MO) diet from weaning, through pregnancy lactation. After C were euthanized at 110 650PND. The livers collected for RNA-seq immunohistochemistry. Male had more differentially expressed genes (DEGs)...
Diabetes mellitus is a chronic non-communicable disease with increasing prevalence in Latin America and worldwide, impacting various social economic areas. It causes numerous complications for those affected. Current treatments diabetes include oral hypoglycemic drugs, which can lead to adverse effects health complications. Other natural alternatives DM treatment have been studied as adjunct therapies reduce or eliminate the need antidiabetic medications. Several supplements may offer an...
Maternal obesity (MO) predisposes F1 offspring to chronic disorders including non-alcoholic fatty liver disease (NAFLD). With aging, the undergoes structural and functional changes associated with metabolic impairment. Mechanism(s) whereby MO and/or aging cause NAFLD are unknown. F0 female rats ate control (C) or obesogenic diet from weaning through lactation. After males C diet. At postnatal day (PND) 110 650 serum OS measures, histology, immunohistochemistry (IHC), transcriptomics...