A5018932570- Cardiac Ischemia and Reperfusion
- Mitochondrial Function and Pathology
- Trace Elements in Health
- Nitric Oxide and Endothelin Effects
- ATP Synthase and ATPases Research
- Cardiac Arrest and Resuscitation
- Genomics, phytochemicals, and oxidative stress
- Metabolism and Genetic Disorders
- Neuroscience and Neuropharmacology Research
- Adipose Tissue and Metabolism
- Coenzyme Q10 studies and effects
- Neurological Disorders and Treatments
- Eicosanoids and Hypertension Pharmacology
- Redox biology and oxidative stress
- Advanced Glycation End Products research
- Glutathione Transferases and Polymorphisms
- Coffee research and impacts
- Biochemical effects in animals
- Cardiovascular Function and Risk Factors
- Curcumin's Biomedical Applications
- Heavy Metal Exposure and Toxicity
- Invertebrate Immune Response Mechanisms
- Heart Failure Treatment and Management
- Pharmacological Effects and Toxicity Studies
- Dye analysis and toxicity
Instituto Nacional de Cardiología
2014-2024
Universidad Nacional Autónoma de México
2011-2018
Instituto Nacional de Cardiologia
2011
This study was designed to investigate if α-mangostin (α-M), a xanthone present in the pericarp of Garcinia mangostana L., able protect against reperfusion injury Langendorff-reperfused hearts. It observed that α-M maintains cardiac mechanical work, diminishes area infarct, and prevents decrease ATP phosphocreatine levels reperfused myocardium. The protective effect this associated with reduction oxidative stress. treatment prevented injury-induced protein oxidation (protein carbonyl...
Cytidine-5'-diphosphocholine (CDP-choline) participates as an intermediary in the synthesis of phosphatidylcholine, essential component cellular membranes. Citicoline treatment has shown beneficial effects cerebral ischemia, but its potential to diminish reperfusion damage liver not been explored. In this work, we evaluated hepatoprotective effect citicoline and possible association with inflammatory/oxidative stress mitochondrial function because they are main features damage....
In the kidney, accumulation of heavy metals such as Cd2+ produces mitochondrial dysfunctions, i.e., uncoupling oxidative phosphorylation, inhibition electron transport through respiratory chain, and collapse transmembrane electrical gradient. This derangement may be due to fact that induces transition membrane permeability from selective nonselective via opening a pore. fact, this injury stimulation oxygen-derived radical generation, inducing stress. Several molecules have been used avoid or...
Atherosclerosis, a major risk factor for cardiovascular diseases is influenced by modifiable factors such as adiposity and blood cholesterol. Diet crucial in these areas, particularly regarding antioxidant, inflammatory, obesity effects. Coffee, globally popular stimulant beverage has garnered significant attention its potential impact on diseases. Recent insights reinforce the need to re-examine relationship between coffee consumption atherosclerosis progression. Coffee’s complex...
Hyperthyroidism represents an increased risk factor for cardiovascular morbidity, especially when the heart is subjected to ischemia/reperfusion process. The aim of this study was explore possible protective effect nucleotide citicoline on susceptibility hyperthyroid rat hearts undergo reperfusion-induced damage, which associated with mitochondrial dysfunction. Hence, we analyzed electrical behavior and function in hearts. established after a daily i.p. injection triiodothyronine (at 2 mg/kg...
Oxidant stress, among other effectors, is implicated in the sequel of myocardial reperfusion injury. It generally accepted that maintaining balance between oxidant and antioxidant signalling within cell provides protection against damage. The cardioprotective strategy postconditioning (PC) reduces injury through complex mechanisms; however, contribution system has not been fully investigated. In this study, isolated rat hearts were subjected to PC after 30 min global ischaemia, then 5 (IR5)...