A5101920398- Amyotrophic Lateral Sclerosis Research
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Parkinson's Disease Mechanisms and Treatments
- Neurogenetic and Muscular Disorders Research
- Psychiatric care and mental health services
- Historical Studies on Reproduction, Gender, Health, and Societal Changes
- Prion Diseases and Protein Misfolding
- Neuroblastoma Research and Treatments
- Healthcare Decision-Making and Restraints
- Medical History and Innovations
- Sarcoma Diagnosis and Treatment
- Historical Psychiatry and Medical Practices
- Phosphorus and nutrient management
- Central Venous Catheters and Hemodialysis
- Cerebrospinal fluid and hydrocephalus
- Health Systems, Economic Evaluations, Quality of Life
- Cancer, Hypoxia, and Metabolism
- Genetic Neurodegenerative Diseases
- Biochemical Acid Research Studies
- Reflective Practices in Education
- Venous Thromboembolism Diagnosis and Management
- Cholinesterase and Neurodegenerative Diseases
- Pharmaceutical studies and practices
- Antibiotics Pharmacokinetics and Efficacy
Memorial University of Newfoundland
2025
Biogen (United States)
2021-2024
University of California, San Francisco
2010-2021
University of Michigan
2021
Syneos Health (United States)
2019
Chartered Society of Physiotherapy
2018
Duke Medical Center
2012-2017
St. James's Hospital
1998-2017
Institute for Clinical Pharmacodynamics (United States)
2017
Clinical Research Institute
2016-2017
<b><i>Background:</i></b> Patients with ALS are often told that the disease spares cognition; however, recent evidence suggests deficits in frontal executive skills occur a sizable minority of patients. In many instances, represent co-occurrence frontotemporal lobar dementia (FTLD) and ALS. <b><i>Methods:</i></b> Word generation, simple task takes <2 minutes, was tested 100 consecutive patients seen authors' multidisciplinary clinic. Any patient prior diagnosis excluded from study. A...
Amyotrophic lateral sclerosis (ALS) is increasingly recognized to be a multisystem disorder which includes both clinical and neuropathological features of frontotemporal lobar degeneration (FTLD). In order provide common framework within discuss the characteristics cognitive behavioural syndromes ALS, with conduct research, an international research workshop on dementia (FTD) ALS was held in London, Canada June 2007. The recommendations arising from this address requirement for concise...
<b>Objective: </b> To investigate the patterns of MRI brain atrophy in patients with ALS and without clinically evident frontotemporal lobar dementia (FTLD) using voxel-based morphometry (VBM). <b>Methods: Voxel-based was used to compare T1-weighted images obtained from ten FTLD, who were cognitively behaviorally normal, 22 control subjects. Images controls spatially pre-processed a study-specific, customized template priori images. A statistical threshold <i>p</i> < 0.05 corrected for...
To determine whether patients with ALS-frontotemporal lobar dementia (FTLD) have a shorter survival and are less compliant recommended treatments than those ALS who normal executive behavioral function (classic ALS).Survival analysis from symptom onset to death included 81 of 100 consecutive could be classified definitely as abnormal or classic ALS. Criteria were defined for compliance noninvasive positive-pressure ventilation (NPPV) percutaneous endoscopic gastrostomy (PEG).Median was 2...
<h3>Objective</h3> To identify the nature and prevalence of cognitive behavioral abnormalities in patients with amyotrophic lateral sclerosis (ALS). <h3>Design</h3> Survey clinical characteristics. <h3>Setting</h3> Multidisciplinary clinic within a university medical center. <h3>Patients</h3> A volunteer sample 30 new ALS were recruited consecutively. Of those invited, 23 participants (20 sporadic 3 familial ALS) enrolled. Participants ranged age from 27 to 80 years (mean age, 56.5 years);...
Up to half of patients with ALS develop cognitive impairment during the course illness. Despite this, there is no simple tool for screening in clinical setting. This study examines sensitivity, specificity and accuracy Cognitive Behavioral Screen (ALS-CBS™). We administered measure 112 patients, including 31 who also underwent comprehensive neuropsychological testing. results were validated by determining against full battery. Optimal cut-off scores predicting correct diagnosis determined,...
The medial preoptic area (MPOA), ventral pallidum (VP), and nucleus accumbens (NA) receive dopaminergic afferents are involved in maternal behavior. Experiments investigated whether dopamine (DA) receptor antagonism NA disrupts behavior, determined the type of DA involved, involvement drug spread to VP or MPOA. Injection SCH 23390 (D1 antagonist) into postpartum rats disrupted retrieving at dosage levels that were ineffective when injected MPOA VP. Motor impairment was not cause deficit....
To characterize the prevalence of cognitive and behavioral symptoms using a cognitive/behavioral screening battery in large prospective multicenter study amyotrophic lateral sclerosis (ALS).
Frontotemporal dementia (FTD) is a progressive neurological condition caused by degeneration of the frontal and/or anterior temporal lobes resulting in personality, behavioral, and cognitive changes. Amyotrophic lateral sclerosis (ALS) lower motor pyramidal neurons, leading to loss voluntary muscle movement. The common molecular pathological anatomical overlaps between FTD ALS suggest that two disorders are strongly linked. In some patients precedes ALS; others occurs first, while still...
To understand phenotypic and molecular characteristics of patients with clinically "definite" primary lateral sclerosis (PLS) in a prospective study.Six sites enrolled 41 who had pure upper motor neuron dysfunction, bulbar symptoms, normal EMG done within 12 months enrollment, onset symptoms ≥5 years before enrollment. For analyses, 27 demographic, clinical, cognitive variables were analyzed using the k-means clustering method. studies, 34 available DNA samples tested for C9ORF72 mutation,...
To evaluate relationships among cognitive, behavioral, and psychiatric/psychosocial measures assessed in a multicenter cohort of patients with amyotrophic lateral sclerosis (ALS).Recently diagnosed definite or probable ALS diagnosis were administered 7 standardized measures, including the Patient Health Questionnaire for depression elicitation wish to die. The Cognitive Behavioral Screen was used classify both cognitive behavioral impairment (emotional-interpersonal function). An version...
Our objective was to evaluate the association between cognitive-behavioral deficits and patient quality of life (QoL), caregiver burden, disease stage in a population patients with amyotrophic lateral sclerosis (ALS). We administered ALS Cognitive-Behavioral Screen™ 86 ALS. Multiple regression used cognitive or behavioral stage, QoL, burden while controlling for clinically important variables. Of participants enrolled, 53 (62%) had some degree impairment, 32 (37%) were behaviorally impaired...
Dalbavancin is a novel lipoglycopeptide antibiotic that has potent in vitro activity against Gram-positive microorganisms.
In a multicenter study of newly diagnosed ALS patients without reported family history ALS, we are prospectively investigating whether markers oxidative stress (OS) associated with disease progression. Methods utilize an extensive structured telephone interview ascertaining environmental, lifestyle, dietary and psychological risk factors OS. Detailed assessments were performed at baseline 3–6 month intervals during the ensuing 30 months. Our biorepository includes DNA, plasma, urine, skin....
The preparation of calcium acetate from mussel (Mytilus edulis) shells and acetic acid was optimised via design experiments. solid product identified as the monohydrate powder X-ray diffraction, IR spectroscopy Thermogravimetric analysis. Comparisons were made to optical grade calcite in place bio-sourced carbonate for synthesis. An exploratory central composite compared yield with respect shell material used (shells dried air at room temperature, 220 °C or calcined), concentration acid,...
The preparation of calcium acetate from mussel (Mytilus edulis) shells and acetic acid was optimised via design experiments. solid product identified as the monohydrate powder X-ray diffraction, IR spectroscopy Thermogravimetric analysis. SEM analysis showed that morphology crystalline consisted prismatic crystals approximate dimensions 100 x 1 1μm. Comparisons were made to optical grade calcite (Iceland spar) in place bio-sourced carbonate for synthesis. An exploratory central composite...
Objective: Volumetric differences in the putamen of boys with ADHD combined subtype psychopathic traits and controls are investigated. Method: The 24 archival magnetic resonance imaging scans 12 residential treatment symptoms community control analyzed using Display software. Results: There no found total, left, right volumes across or group. A significant reversal asymmetry groups is found; children more frequently have a smaller left than right. In contrast, group has putamen. Conclusion:...
The University of California San Francisco (UCSF) Screening Battery provides clinicians with a uniquely tailored tool to measure ALS patients' cognitive and behavioral changes, adjusting for dysarthria hand weakness. battery consists the ALS-CBS (1 Woolley SC, York MK, Moore DH, Strutt AM, Murphy J, Schulz PE, et al. Detecting frontotemporal dysfunction in ALS: utility Cognitive Behavioral Screen (ALS-CBS). Amyotroph Lateral Scler. 2010;11:303–11.[Taylor & Francis Online], [Web Science ®] ,...
To prospectively evaluate the progression of cognitive-behavioral function in amyotrophic lateral sclerosis (ALS) and examine association deficits with disease progression, patient quality life (QOL), caregiver burden.We evaluated using Amyotrophic Lateral Sclerosis Cognitive Behavioral Screen at enrollment after 7 months a cohort patients ALS. Paired t tests were used to change 2 assessments. Linear regression Kruskal-Wallis applied investigate how initial cognitive or behavioral status...
Objective . To evaluate longitudinal cognitive/behavioral change over 12 months in participants enrolled the ALS Multicenter Cohort Study of Oxidative Stress (ALS COSMOS). Methods We analyzed data from 294 participants, 134 whom were studied serially. Change time was evaluated controlling for age, sex, symptom duration, education, race, and ethnicity. Using multiple regression, we associations among decline Functional Rating Scale-Revised (ALSFRS-R) scores, forced vital capacity (FVC),...