A5113010012- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Autism Spectrum Disorder Research
- Dementia and Cognitive Impairment Research
- Obsessive-Compulsive Spectrum Disorders
- Balance, Gait, and Falls Prevention
- Schizophrenia research and treatment
- Family Support in Illness
- Alzheimer's disease research and treatments
- Biochemical Analysis and Sensing Techniques
- Family and Disability Support Research
- Intelligent Tutoring Systems and Adaptive Learning
- Attention Deficit Hyperactivity Disorder
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Botulinum Toxin and Related Neurological Disorders
- Ginkgo biloba and Cashew Applications
- Psychometric Methodologies and Testing
- Cerebral Palsy and Movement Disorders
- Stroke Rehabilitation and Recovery
- Writing and Handwriting Education
- Assistive Technology in Communication and Mobility
- Cognitive Functions and Memory
- Advanced Chemical Sensor Technologies
- Health Systems, Economic Evaluations, Quality of Life
- Family Caregiving in Mental Illness
University of Pennsylvania
2015-2025
University of Iowa
2024
Rutgers, The State University of New Jersey
2024
John Wiley & Sons (United States)
2023
California University of Pennsylvania
2020-2023
Foundation for Human Potential
2010
Teva Pharmaceuticals (Hungary)
2007
Boehringer Ingelheim (Canada)
2007
Abstract Impulse control disorders and related (hobbyism‐punding dopamine dysregulation syndrome) occur in 15% to 20% of Parkinson's disease (PD) patients. We assessed the validity reliability Questionnaire for Impulsive‐Compulsive Disorders Disease–Rating Scale (QUIP‐RS), a rating scale designed measure severity symptoms support diagnosis impulse PD. A convenience sample PD patients at movement clinic self‐completed QUIP‐RS were administered semistructured diagnostic interview by blinded...
Recent studies have linked dopamine agonist (DA) usage with the development of impulse control disorders (ICDs) in Parkinson's disease (PD). Little is known about optimal management strategies or long-term outcomes affected patients. To report on clinical interventions and PD patients who developed an ICD after DA initiation. Subjects contacted by telephone for a follow-up interview mean time period 29.2 months. They were administered modified Minnesota Impulse Disorder Interview compulsive...
As many as 60% of patients with Parkinson disease (PD) experience psychosis, 80% develop dementia, and the use antipsychotics (APs) in population PD is common. The APs by dementia general associated increased mortality, but whether this risk extends to remains unknown.
A range of impulse control disorders (ICDs) are reported to occur in Parkinson's disease (PD). However, alterations brain activity at rest and during risk taking occurring with ICDs PD not well understood. We used both arterial spin labeling perfusion functional magnetic resonance imaging (fMRI) directly quantify resting cerebral blood flow (CBF) oxygenation level dependent (BOLD) fMRI measure neural responses performance on the Balloon Analogue Risk Task (BART). Eighteen patients, either a...
Abstract Mild cognitive impairment (MCI) in Parkinson's disease (PD) may be associated with subtle functional and worse quality of life. The objective this study was to determine the efficacy tolerability rivastigmine for PD‐MCI. Patients PD‐MCI (n = 28) were enrolled a 24‐week, randomized, double‐blind, placebo‐controlled, crossover, single‐site transdermal patch. primary outcome measure Alzheimer's Disease Cooperative Study—Clinical Global Impression Change (ADCS‐CGIC). Secondary outcomes...
Abstract Background The Movement Disorder Society–sponsored Nonmotor Rating Scale is an update of the existing Parkinson's disease Symptoms modified to address some limitations in scoring, structure, and symptom coverage. Methods PD patients were recruited from movement disorder centers international, multicenter study. Society Scale, consisting 13 domains plus a subscale for nonmotor fluctuations, was rater administered, along with other clinical assessments. Standard reliability validity...
It is widely cited that dementia occurs in up to 80% of patients with Parkinson disease (PD), but studies reporting such high rates were published over two decades ago, had relatively small samples, and other limitations. We aimed determine long-term risk PD using data from large, ongoing, prospective, observational studies.
Abstract Background The burden of non‐motor symptoms in Parkinson's disease (PD) can be measured with the Non‐Motor Symptoms Scale (NMSS) and International Parkinson Movement Disorder Society Rating (MDS‐NMS), for which scoring systems, structure clinical coverage differ. Objectives goal was to develop conversion formulas between NMSS MDS‐NMS scores. Methods Data from 402 patients PD participating primary validation study were used. association domain total scores both scales assessed by...
Abstract Hyposmia, psychiatric disorders, and cognitive problems are common nonmotor manifestations in Parkinson's disease, but how they related remains unclear. We investigated the relationship between olfactory dysfunction neuropsychiatric performed a cross‐sectional study of 248 patients at two movement disorders clinics academic medical centers. Psychiatric measures were Geriatric Depression Scale‐15, Inventory Depressive Symptomatology, State Anxiety Inventory, Apathy Scale, Psychosis...
A" was diagnosed with Parkinson's disease at 51 years of age, 5 after seeing a neurologist for variety symptoms, ranging from assumed complications bulging vertebral discs, cervical radiculopathy, headaches, and carpal tunnel syndrome.Ultimately, she referred to movement disorders who assessed her pain, decreased left upper extremity dexterity arm swing, gait stiffness weakness, rigidity, as well prominent depression anxiety received diagnosis mild idiopathic (stage 1.5 on the Hoehn Yahr...
Abstract Objective To develop a clinico‐genetic predictor of impulse control disorder (ICD) risk in Parkinson's disease (PD). Methods In 5770 individuals from three PD cohorts (the 23andMe, Inc.; the University Pennsylvania [UPenn]; and Progression Markers Initiative [PPMI]), we used discovery‐replication strategy to for ICD risk. We first performed Genomewide Association Study (GWAS) ICDs anytime during 5262 23andMe cohort. then combined newly discovered loci with 13 previously reported...
Abstract Background The Movement Disorder Society Non‐Motor Rating Scale (MDS‐NMS) assesses severity and frequency of non‐motor symptoms (NMS) in Parkinson's disease (PD) is rater‐administered. MDS‐NMS Questionnaire (MDS‐NMS‐Q), developed as a briefer (i.e., assessing symptom only), self‐completed version the MDS‐NMS, also 13‐domain, 52‐symptom instrument with separate fluctuations (NMFs) section. Objective goal was to validate MDS‐NMS‐Q versus MDS‐NMS. Methods A cross‐sectional, multi‐site,...
Abstract Background The effect of surgery on impulse control disorders (ICDs) remains unclear in Parkinson's disease (PD) patients undergoing deep brain stimulation (DBS). Objective To examine changes ICD symptoms PD DBS compared to a medication‐only group. Methods study was 2‐center, 12‐month, prospective, observational investigation and group matched age, sex, dopamine agonist use, baseline presence ICDs. Questionnaire for Impulsive‐Compulsive Disorders Disease‐Rating Scale (QUIP‐RS) total...
Parkinson's disease (PD) significantly impacts both patients' and spouses' emotional physical health. However, despite the importance of social relationships for wellbeing, few studies have examined relationship quality their correlates in individuals with PD partners. Specifically, no known association between benefit finding, or experience personal growth other positive changes face a stressor, perceived marital quality. To address these gaps field, 25 married couples participated...
COVID-19 has highlighted the need for remote cognitive testing, but reliability and validity of virtual testing in Parkinson disease (PD) is unknown. Therefore, we assessed PD participants enrolled an observational, cognition-focused study with extensive battery completed both in-person via video conference close time. Data 35 normal cognition to mild dementia were analyzed. Only one test (semantic verbal fluency) demonstrated a difference score by administration type, significantly better...
Fatigue in Parkinson's disease (PD) is multifaceted and associated with reduced quality of life. In turn, the language used by people PD to describe fatigue variable poorly understood. We sought elucidate lexicon using a qualitative grounded theory approach.The objective this study was understand how patients fatigue.A pre-study phase online journaling (Phase 1) provided information regarding topics importance patients. Following this, two independent samples fatigued subjects were studied....
Background Parkinson’s disease psychosis (PDP) has a major impact on quality of life and care partner burden; however, little is known about the lived experiences partners in managing PDP. Objective To understand how individuals with PDP experience their role articulate needs related to psychosis. Methods This was qualitative study semi-structured telephone interviews. Recruitment conducted online via clinical matching tool, Fox Trial Finder; activities took place remotely Transcripts phone...
Fatigue is a highly prevalent and debilitating non-motor symptom in Parkinson’s disease (PD), yet its’ neural mechanisms remain poorly understood. Here we combined arterial spin labeling (ASL) perfusion functional magnetic resonance imaging (fMRI) with sustained mental workload paradigm to examine the correlates of fatigue time-on-task effects PD patients. Twenty-one patients were scanned at rest during continuous performance 20-min psychomotor vigilance test (PVT). Time-on-task measured by...
Background: A composite measure that assesses both cognitive and functional abilities in Parkinson’s disease (PD) would be useful for diagnosing mild impairment (MCI) PD dementia (PDD) as an outcome randomized controlled trials. The Clinical Dementia Rating Scale Sum of Boxes (CDR-SOB) was designed to assess cognition basic-instrumental activities daily living Alzheimer’s but has not yet been validated PD. Objective: To validate the CDR-SOB a cognitive-functional patients, well its...
ABSTRACT Background Parkinson’s disease psychosis (PDP) has a major impact on quality of life and care partner burden; however, little is known about the lived experiences partners in managing PDP. Objective To understand how individuals with PDP experience their role articulate needs related to psychosis. Methods This was qualitative study semi-structured telephone interviews. Recruitment conducted online via clinical matching tool, Fox Trial Finder; activities took place remotely...